Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378468855> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4378468855 endingPage "20" @default.
- W4378468855 startingPage "20" @default.
- W4378468855 abstract "Variations in the hepatitis C virus (HCV) core sequence have been related to disease progression and response to antiviral therapy. Previously we showed that the methylation status of RASSF1A and p16 genes, and IL28B genotypes affects the response to pegylated interferon/ribavirin (PEG-IFN/RBV) therapy. Herein we investigated whether amino acid (aa) substitutions in the HCV core region alone or in combination with IL28B genotypes and RASSF1A/p16 methylation affect the response to PEG-IFN/RBV therapy and liver disease progression. Among 29 examined patients, we found no association between single aa substitutions and response to therapy. However, we observed that patients with the HCV core aa substitution at position 75 and CT/TT IL28B genotypes were nonresponders (NR), (P=0.023). Moreover, these patients had unmethylated RASSF1A. In contrast, most patients (75%) with aa substitutions at position 91 and CC IL28B genotype achieved sustained virologic response (SVR), (P=0.030), and 70% of them had methylated RASSF1A gene. Our results suggest that combined analysis of aa substitutions in the core protein, the IL28B rs12979860 polymorphism, and the methylation status of the RASSF1A gene may help in predicting treatment response to PEG-IFN/RBV in genotype 1b chronic hepatitis C patients." @default.
- W4378468855 created "2023-05-27" @default.
- W4378468855 creator A5026285822 @default.
- W4378468855 creator A5033015063 @default.
- W4378468855 creator A5035893885 @default.
- W4378468855 creator A5038971281 @default.
- W4378468855 creator A5045602628 @default.
- W4378468855 creator A5054549347 @default.
- W4378468855 creator A5063450991 @default.
- W4378468855 date "2023-01-01" @default.
- W4378468855 modified "2023-09-27" @default.
- W4378468855 title "Variability of the HCV core region and host genetic and epigenetic factors can predict the response to pegylated interferon/ribavirin therapy in genotype 1B hepatitis C patients from Serbia" @default.
- W4378468855 doi "https://doi.org/10.2298/abs230316020k" @default.
- W4378468855 hasPublicationYear "2023" @default.
- W4378468855 type Work @default.
- W4378468855 citedByCount "0" @default.
- W4378468855 crossrefType "journal-article" @default.
- W4378468855 hasAuthorship W4378468855A5026285822 @default.
- W4378468855 hasAuthorship W4378468855A5033015063 @default.
- W4378468855 hasAuthorship W4378468855A5035893885 @default.
- W4378468855 hasAuthorship W4378468855A5038971281 @default.
- W4378468855 hasAuthorship W4378468855A5045602628 @default.
- W4378468855 hasAuthorship W4378468855A5054549347 @default.
- W4378468855 hasAuthorship W4378468855A5063450991 @default.
- W4378468855 hasBestOaLocation W43784688551 @default.
- W4378468855 hasConcept C104317684 @default.
- W4378468855 hasConcept C135763542 @default.
- W4378468855 hasConcept C159047783 @default.
- W4378468855 hasConcept C203014093 @default.
- W4378468855 hasConcept C2522874641 @default.
- W4378468855 hasConcept C2776178377 @default.
- W4378468855 hasConcept C2776408679 @default.
- W4378468855 hasConcept C2776455275 @default.
- W4378468855 hasConcept C2776461080 @default.
- W4378468855 hasConcept C2776999253 @default.
- W4378468855 hasConcept C2777075537 @default.
- W4378468855 hasConcept C2780040827 @default.
- W4378468855 hasConcept C33288867 @default.
- W4378468855 hasConcept C54355233 @default.
- W4378468855 hasConcept C60644358 @default.
- W4378468855 hasConcept C71924100 @default.
- W4378468855 hasConcept C86803240 @default.
- W4378468855 hasConcept C90924648 @default.
- W4378468855 hasConceptScore W4378468855C104317684 @default.
- W4378468855 hasConceptScore W4378468855C135763542 @default.
- W4378468855 hasConceptScore W4378468855C159047783 @default.
- W4378468855 hasConceptScore W4378468855C203014093 @default.
- W4378468855 hasConceptScore W4378468855C2522874641 @default.
- W4378468855 hasConceptScore W4378468855C2776178377 @default.
- W4378468855 hasConceptScore W4378468855C2776408679 @default.
- W4378468855 hasConceptScore W4378468855C2776455275 @default.
- W4378468855 hasConceptScore W4378468855C2776461080 @default.
- W4378468855 hasConceptScore W4378468855C2776999253 @default.
- W4378468855 hasConceptScore W4378468855C2777075537 @default.
- W4378468855 hasConceptScore W4378468855C2780040827 @default.
- W4378468855 hasConceptScore W4378468855C33288867 @default.
- W4378468855 hasConceptScore W4378468855C54355233 @default.
- W4378468855 hasConceptScore W4378468855C60644358 @default.
- W4378468855 hasConceptScore W4378468855C71924100 @default.
- W4378468855 hasConceptScore W4378468855C86803240 @default.
- W4378468855 hasConceptScore W4378468855C90924648 @default.
- W4378468855 hasFunder F4320322729 @default.
- W4378468855 hasIssue "00" @default.
- W4378468855 hasLocation W43784688551 @default.
- W4378468855 hasOpenAccess W4378468855 @default.
- W4378468855 hasPrimaryLocation W43784688551 @default.
- W4378468855 hasRelatedWork W118298973 @default.
- W4378468855 hasRelatedWork W1569617516 @default.
- W4378468855 hasRelatedWork W1967080996 @default.
- W4378468855 hasRelatedWork W1991118604 @default.
- W4378468855 hasRelatedWork W2018887507 @default.
- W4378468855 hasRelatedWork W2049845414 @default.
- W4378468855 hasRelatedWork W2368760195 @default.
- W4378468855 hasRelatedWork W2884220646 @default.
- W4378468855 hasRelatedWork W2985450305 @default.
- W4378468855 hasRelatedWork W28993079 @default.
- W4378468855 isParatext "false" @default.
- W4378468855 isRetracted "false" @default.
- W4378468855 workType "article" @default.