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• W4378471131 abstract "Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role of TRABID in suppressing anti-tumor immunity. Mechanistically, TRABID is upregulated in mitosis and governs mitotic cell division by removing K29-linked polyubiquitin chain from Aurora B and Survivin, thereby stabilizing the entire chromosomal passenger complex. TRABID inhibition causes micronuclei through a combinatory defect in mitosis and autophagy and protects cGAS from autophagic degradation, thereby activating the cGAS/STING innate immunity pathway. Genetic or pharmacological inhibition of TRABID promotes anti-tumor immune surveillance and sensitizes tumors to anti-PD-1 therapy in preclinical cancer models in male mice. Clinically, TRABID expression in most solid cancer types correlates inversely with an interferon signature and infiltration of anti-tumor immune cells. Our study identifies a suppressive role of tumor-intrinsic TRABID in anti-tumor immunity and highlights TRABID as a promising target for sensitizing solid tumors to immunotherapy." @default.
• W4378471131 created "2023-05-27" @default.
• W4378471131 creator A5002394486 @default.
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• W4378471131 date "2023-05-26" @default.
• W4378471131 modified "2023-09-26" @default.
• W4378471131 title "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation" @default.
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• W4378471131 cites W2016771009 @default.
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• W4378471131 cites W2025718369 @default.
• W4378471131 cites W2027169351 @default.
• W4378471131 cites W2040217580 @default.
• W4378471131 cites W2040478292 @default.
• W4378471131 cites W2042950864 @default.
• W4378471131 cites W2050723856 @default.
• W4378471131 cites W2059292258 @default.
• W4378471131 cites W2086250743 @default.
• W4378471131 cites W2086286750 @default.
• W4378471131 cites W2086956798 @default.
• W4378471131 cites W2095617425 @default.
• W4378471131 cites W2125624250 @default.
• W4378471131 cites W2143878771 @default.
• W4378471131 cites W2155961719 @default.
• W4378471131 cites W2260331558 @default.
• W4378471131 cites W2264770266 @default.
• W4378471131 cites W2293022769 @default.
• W4378471131 cites W2395943362 @default.
• W4378471131 cites W2469758901 @default.
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• W4378471131 cites W2618634776 @default.
• W4378471131 cites W2733154631 @default.
• W4378471131 cites W2735349030 @default.
• W4378471131 cites W2738136165 @default.
• W4378471131 cites W2740618823 @default.
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• W4378471131 cites W2762198049 @default.
• W4378471131 cites W2762611634 @default.
• W4378471131 cites W2766243612 @default.
• W4378471131 cites W2773964572 @default.
• W4378471131 cites W2783667606 @default.
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• W4378471131 cites W2805354595 @default.
• W4378471131 cites W2891127847 @default.
• W4378471131 cites W2903746377 @default.
• W4378471131 cites W2923237125 @default.
• W4378471131 cites W2925395230 @default.
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• W4378471131 cites W2969538494 @default.
• W4378471131 cites W2977255036 @default.
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• W4378471131 cites W3116800993 @default.
• W4378471131 cites W3119259933 @default.
• W4378471131 cites W3127317114 @default.
• W4378471131 cites W3128042128 @default.
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• W4378471131 cites W3164702212 @default.
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• W4378471131 doi "https://doi.org/10.1038/s41467-023-38784-z" @default.
• W4378471131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37237031" @default.
• W4378471131 hasPublicationYear "2023" @default.
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