FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378471572> ?p ?o ?g. }

• W4378471572 abstract "Abstract Non-coding regulatory elements such as enhancers are key in controlling the cell-type specificity and spatio-temporal expression of genes. To drive stable and precise gene transcription robust to genetic variation and environmental stress, genes are often targeted by multiple enhancers with redundant action. However, it is unknown whether enhancers targeting the same gene display simultaneous activity or whether some enhancer combinations are more often co-active than others. Here, we take advantage of recent developments in single cell technology that permit assessing chromatin status (scATAC-seq) and gene expression (scRNA-seq) in the same single cells to correlate gene expression to the activity of multiple enhancers. Measuring activity patterns across 24,844 human lymphoblastoid single cells, we find that the majority of enhancers associated with the same gene display significant correlation in their chromatin profiles. For 6944 expressed genes associated with enhancers, we predict 89,885 significant enhancer-enhancer associations between nearby enhancers. We find that associated enhancers share similar transcription factor binding profiles and that gene essentiality is linked with higher enhancer co-activity. We provide a set of predicted enhancer-enhancer associations based on correlation derived from a single cell line, which can be further investigated for functional relevance." @default.
• W4378471572 created "2023-05-27" @default.
• W4378471572 creator A5010960261 @default.
• W4378471572 creator A5026984064 @default.
• W4378471572 creator A5031990107 @default.
• W4378471572 date "2023-05-26" @default.
• W4378471572 modified "2023-10-02" @default.
• W4378471572 title "Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line" @default.
• W4378471572 cites W1964480889 @default.
• W4378471572 cites W1973062929 @default.
• W4378471572 cites W1987839415 @default.
• W4378471572 cites W2058999737 @default.
• W4378471572 cites W2133870073 @default.
• W4378471572 cites W2137465688 @default.
• W4378471572 cites W2146042781 @default.
• W4378471572 cites W2162641630 @default.
• W4378471572 cites W2171808845 @default.
• W4378471572 cites W2464000940 @default.
• W4378471572 cites W2786174959 @default.
• W4378471572 cites W2889236955 @default.
• W4378471572 cites W2901749533 @default.
• W4378471572 cites W2942757851 @default.
• W4378471572 cites W2955723825 @default.
• W4378471572 cites W2976185077 @default.
• W4378471572 cites W2979343233 @default.
• W4378471572 cites W2991283206 @default.
• W4378471572 cites W3004748148 @default.
• W4378471572 cites W3029661147 @default.
• W4378471572 cites W3034083044 @default.
• W4378471572 cites W3047725782 @default.
• W4378471572 cites W3078045561 @default.
• W4378471572 cites W3093858607 @default.
• W4378471572 cites W3111061871 @default.
• W4378471572 cites W3114485724 @default.
• W4378471572 cites W3119327744 @default.
• W4378471572 cites W3127556601 @default.
• W4378471572 cites W3134809854 @default.
• W4378471572 cites W3151678771 @default.
• W4378471572 cites W3156113107 @default.
• W4378471572 cites W3164692211 @default.
• W4378471572 cites W3192450633 @default.
• W4378471572 cites W3193839790 @default.
• W4378471572 cites W3207880742 @default.
• W4378471572 cites W3210860076 @default.
• W4378471572 cites W3212334377 @default.
• W4378471572 cites W3213027475 @default.
• W4378471572 cites W4200278514 @default.
• W4378471572 cites W4206092375 @default.
• W4378471572 cites W4213140257 @default.
• W4378471572 cites W4223893712 @default.
• W4378471572 cites W4223992851 @default.
• W4378471572 cites W4280594254 @default.
• W4378471572 cites W4281555558 @default.
• W4378471572 cites W4292979605 @default.
• W4378471572 cites W4293175910 @default.
• W4378471572 cites W4361212789 @default.
• W4378471572 cites W4378471572 @default.
• W4378471572 doi "https://doi.org/10.1038/s42003-023-04954-4" @default.
• W4378471572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37237005" @default.
• W4378471572 hasPublicationYear "2023" @default.
• W4378471572 type Work @default.
• W4378471572 citedByCount "1" @default.
• W4378471572 countsByYear W43784715722023 @default.
• W4378471572 crossrefType "journal-article" @default.
• W4378471572 hasAuthorship W4378471572A5010960261 @default.
• W4378471572 hasAuthorship W4378471572A5026984064 @default.
• W4378471572 hasAuthorship W4378471572A5031990107 @default.
• W4378471572 hasBestOaLocation W43784715721 @default.
• W4378471572 hasConcept C104317684 @default.
• W4378471572 hasConcept C111936080 @default.
• W4378471572 hasConcept C150194340 @default.
• W4378471572 hasConcept C165864922 @default.
• W4378471572 hasConcept C21784809 @default.
• W4378471572 hasConcept C54355233 @default.
• W4378471572 hasConcept C70721500 @default.
• W4378471572 hasConcept C83640560 @default.
• W4378471572 hasConcept C86339819 @default.
• W4378471572 hasConcept C86803240 @default.
• W4378471572 hasConceptScore W4378471572C104317684 @default.
• W4378471572 hasConceptScore W4378471572C111936080 @default.
• W4378471572 hasConceptScore W4378471572C150194340 @default.
• W4378471572 hasConceptScore W4378471572C165864922 @default.
• W4378471572 hasConceptScore W4378471572C21784809 @default.
• W4378471572 hasConceptScore W4378471572C54355233 @default.
• W4378471572 hasConceptScore W4378471572C70721500 @default.
• W4378471572 hasConceptScore W4378471572C83640560 @default.
• W4378471572 hasConceptScore W4378471572C86339819 @default.
• W4378471572 hasConceptScore W4378471572C86803240 @default.
• W4378471572 hasFunder F4320320924 @default.
• W4378471572 hasFunder F4320332999 @default.
• W4378471572 hasIssue "1" @default.
• W4378471572 hasLocation W43784715721 @default.
• W4378471572 hasLocation W43784715722 @default.
• W4378471572 hasOpenAccess W4378471572 @default.
• W4378471572 hasPrimaryLocation W43784715721 @default.
• W4378471572 hasRelatedWork W1986586739 @default.
• W4378471572 hasRelatedWork W2187435303 @default.
• W4378471572 hasRelatedWork W2549332635 @default.
• W4378471572 hasRelatedWork W2600490673 @default.
• W4378471572 hasRelatedWork W2609050486 @default.

• next