Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378472467> ?p ?o ?g. }
- W4378472467 endingPage "9278" @default.
- W4378472467 startingPage "9278" @default.
- W4378472467 abstract "Pregnancy is characterized by a delicate immune balance; therefore, infectious diseases might increase the risk of adverse pregnancy outcomes (APOs). Here, we hypothesize that pyroptosis, a unique cell death pathway mediated by the NLRP3 inflammasome, could link SARS-CoV-2 infection, inflammation, and APOs. Two blood samples were collected from 231 pregnant women at 11–13 weeks of gestation and in the perinatal period. At each time point, SARS-CoV-2 antibodies and neutralizing antibody titers were measured by ELISA and microneutralization (MN) assays, respectively. Plasmatic NLRP3 was determined by ELISA. Fourteen miRNAs selected for their role in inflammation and/or pregnancy were quantified by qPCR and further investigated by miRNA-gene target analysis. NLRP3 levels were positively associated with nine circulating miRNAs, of which miR-195-5p was increased only in MN+ women (p-value = 0.017). Pre-eclampsia was associated with a decrease in miR-106a-5p (p-value = 0.050). miR-106a-5p (p-value = 0.026) and miR-210-3p (p-value = 0.035) were increased in women with gestational diabetes. Women giving birth to small for gestational age babies had lower miR-106a-5p and miR-21-5p (p-values = 0.001 and 0.036, respectively), and higher miR-155-5p levels (p-value = 0.008). We also observed that neutralizing antibodies and NLRP3 concentrations could affect the association between APOs and miRNAs. Our findings suggest for the first time a possible link between COVID-19, NLRP3-mediated pyroptosis, inflammation, and APOs. Circulating miRNAs might be suitable candidates to gain a comprehensive view of this complex interplay." @default.
- W4378472467 created "2023-05-27" @default.
- W4378472467 creator A5000687130 @default.
- W4378472467 creator A5007836073 @default.
- W4378472467 creator A5014044281 @default.
- W4378472467 creator A5021092042 @default.
- W4378472467 creator A5040377654 @default.
- W4378472467 creator A5051447865 @default.
- W4378472467 creator A5056994530 @default.
- W4378472467 creator A5058165155 @default.
- W4378472467 creator A5062753390 @default.
- W4378472467 creator A5070486956 @default.
- W4378472467 creator A5078728203 @default.
- W4378472467 creator A5091757075 @default.
- W4378472467 date "2023-05-25" @default.
- W4378472467 modified "2023-09-30" @default.
- W4378472467 title "Pyroptosis: A Promising Mechanism Linking SARS-CoV-2 Infection to Adverse Pregnancy Outcomes" @default.
- W4378472467 cites W1509926487 @default.
- W4378472467 cites W1665517288 @default.
- W4378472467 cites W1927491384 @default.
- W4378472467 cites W1989029018 @default.
- W4378472467 cites W2083685654 @default.
- W4378472467 cites W2084708403 @default.
- W4378472467 cites W2094006394 @default.
- W4378472467 cites W2105423509 @default.
- W4378472467 cites W2105744234 @default.
- W4378472467 cites W2107277218 @default.
- W4378472467 cites W2143119237 @default.
- W4378472467 cites W2192080449 @default.
- W4378472467 cites W2259283624 @default.
- W4378472467 cites W2736819442 @default.
- W4378472467 cites W2754805617 @default.
- W4378472467 cites W2790287606 @default.
- W4378472467 cites W2799774436 @default.
- W4378472467 cites W2893709640 @default.
- W4378472467 cites W2910525290 @default.
- W4378472467 cites W2944598794 @default.
- W4378472467 cites W2954437518 @default.
- W4378472467 cites W2954782052 @default.
- W4378472467 cites W2990001356 @default.
- W4378472467 cites W2994300733 @default.
- W4378472467 cites W3006769323 @default.
- W4378472467 cites W3013658249 @default.
- W4378472467 cites W3018603329 @default.
- W4378472467 cites W3022376279 @default.
- W4378472467 cites W3029964059 @default.
- W4378472467 cites W3086304026 @default.
- W4378472467 cites W3087196207 @default.
- W4378472467 cites W3088565218 @default.
- W4378472467 cites W3091956488 @default.
- W4378472467 cites W3093093332 @default.
- W4378472467 cites W3102661862 @default.
- W4378472467 cites W3106666665 @default.
- W4378472467 cites W3108557049 @default.
- W4378472467 cites W3109251337 @default.
- W4378472467 cites W3112798430 @default.
- W4378472467 cites W3113228067 @default.
- W4378472467 cites W3118581546 @default.
- W4378472467 cites W3119186431 @default.
- W4378472467 cites W3119979733 @default.
- W4378472467 cites W3131456650 @default.
- W4378472467 cites W3135203598 @default.
- W4378472467 cites W3138312608 @default.
- W4378472467 cites W3138907726 @default.
- W4378472467 cites W3139029911 @default.
- W4378472467 cites W3142080073 @default.
- W4378472467 cites W3153674573 @default.
- W4378472467 cites W3162538759 @default.
- W4378472467 cites W3166319751 @default.
- W4378472467 cites W3177350379 @default.
- W4378472467 cites W3206257957 @default.
- W4378472467 cites W3207663138 @default.
- W4378472467 cites W3214900910 @default.
- W4378472467 cites W4200308842 @default.
- W4378472467 cites W4200488709 @default.
- W4378472467 cites W4210842994 @default.
- W4378472467 cites W4221133256 @default.
- W4378472467 cites W4225890110 @default.
- W4378472467 cites W4248228032 @default.
- W4378472467 cites W4281862316 @default.
- W4378472467 cites W4281986540 @default.
- W4378472467 cites W4284899516 @default.
- W4378472467 cites W4286559831 @default.
- W4378472467 cites W4292737728 @default.
- W4378472467 cites W4294550707 @default.
- W4378472467 cites W4294713053 @default.
- W4378472467 cites W4308059034 @default.
- W4378472467 cites W4311387241 @default.
- W4378472467 cites W3081445549 @default.
- W4378472467 doi "https://doi.org/10.3390/ijms24119278" @default.
- W4378472467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37298229" @default.
- W4378472467 hasPublicationYear "2023" @default.
- W4378472467 type Work @default.
- W4378472467 citedByCount "0" @default.
- W4378472467 crossrefType "journal-article" @default.
- W4378472467 hasAuthorship W4378472467A5000687130 @default.
- W4378472467 hasAuthorship W4378472467A5007836073 @default.
- W4378472467 hasAuthorship W4378472467A5014044281 @default.