Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378515030> ?p ?o ?g. }
- W4378515030 endingPage "1067" @default.
- W4378515030 startingPage "1067" @default.
- W4378515030 abstract "Prenatal alcohol exposure affects the cardiovascular health of the offspring. Epigallocatechin-3-gallate (EGCG) may be a protective agent against it, but no data are available regarding its impact on cardiac dysfunction. We investigated the presence of cardiac alterations in mice prenatally exposed to alcohol and the effect of postnatal EGCG treatment on cardiac function and related biochemical pathways. C57BL/6J pregnant mice received 1.5 g/kg/day (Mediterranean pattern), 4.5 g/kg/day (binge pattern) of ethanol, or maltodextrin until Day 19 of pregnancy. Post-delivery, treatment groups received EGCG-supplemented water. At post-natal Day 60, functional echocardiographies were performed. Heart biomarkers of apoptosis, oxidative stress, and cardiac damage were analyzed by Western blot. BNP and Hif1α increased and Nrf2 decreased in mice prenatally exposed to the Mediterranean alcohol pattern. Bcl-2 was downregulated in the binge PAE drinking pattern. Troponin I, glutathione peroxidase, and Bax increased in both ethanol exposure patterns. Prenatal alcohol exposure led to cardiac dysfunction in exposed mice, evidenced by a reduced ejection fraction, left ventricle posterior wall thickness at diastole, and Tei index. EGCG postnatal therapy restored the physiological levels of these biomarkers and improved cardiac dysfunction. These findings suggest that postnatal EGCG treatment attenuates the cardiac damage caused by prenatal alcohol exposure in the offspring." @default.
- W4378515030 created "2023-05-28" @default.
- W4378515030 creator A5007067903 @default.
- W4378515030 creator A5023115599 @default.
- W4378515030 creator A5024560339 @default.
- W4378515030 creator A5038233948 @default.
- W4378515030 creator A5044866867 @default.
- W4378515030 creator A5053969852 @default.
- W4378515030 creator A5075194918 @default.
- W4378515030 creator A5077501663 @default.
- W4378515030 creator A5088703636 @default.
- W4378515030 creator A5092032192 @default.
- W4378515030 creator A5092032193 @default.
- W4378515030 date "2023-05-09" @default.
- W4378515030 modified "2023-10-09" @default.
- W4378515030 title "Effect of Postnatal Epigallocatechin-Gallate Treatment on Cardiac Function in Mice Prenatally Exposed to Alcohol" @default.
- W4378515030 cites W1512100404 @default.
- W4378515030 cites W1537125811 @default.
- W4378515030 cites W1549439681 @default.
- W4378515030 cites W1594646200 @default.
- W4378515030 cites W1833413198 @default.
- W4378515030 cites W1848529104 @default.
- W4378515030 cites W1854266140 @default.
- W4378515030 cites W1977156046 @default.
- W4378515030 cites W1982756660 @default.
- W4378515030 cites W1992683708 @default.
- W4378515030 cites W1997563282 @default.
- W4378515030 cites W2000592950 @default.
- W4378515030 cites W2001072821 @default.
- W4378515030 cites W2014112740 @default.
- W4378515030 cites W2017624393 @default.
- W4378515030 cites W2031843277 @default.
- W4378515030 cites W2032646817 @default.
- W4378515030 cites W2038820792 @default.
- W4378515030 cites W2050781125 @default.
- W4378515030 cites W2055698030 @default.
- W4378515030 cites W2055861952 @default.
- W4378515030 cites W2057913922 @default.
- W4378515030 cites W2068321058 @default.
- W4378515030 cites W2079593152 @default.
- W4378515030 cites W2086671141 @default.
- W4378515030 cites W2086688886 @default.
- W4378515030 cites W2090054477 @default.
- W4378515030 cites W2093994322 @default.
- W4378515030 cites W2105408725 @default.
- W4378515030 cites W2110075349 @default.
- W4378515030 cites W2116564435 @default.
- W4378515030 cites W2117152239 @default.
- W4378515030 cites W2124351050 @default.
- W4378515030 cites W2135367229 @default.
- W4378515030 cites W2135785702 @default.
- W4378515030 cites W2137119117 @default.
- W4378515030 cites W2142432563 @default.
- W4378515030 cites W2147309646 @default.
- W4378515030 cites W2153587608 @default.
- W4378515030 cites W2161029943 @default.
- W4378515030 cites W2166727347 @default.
- W4378515030 cites W2167018928 @default.
- W4378515030 cites W2222884808 @default.
- W4378515030 cites W2341486516 @default.
- W4378515030 cites W2358484352 @default.
- W4378515030 cites W2401177577 @default.
- W4378515030 cites W2413438453 @default.
- W4378515030 cites W2413465592 @default.
- W4378515030 cites W2467284630 @default.
- W4378515030 cites W2492998196 @default.
- W4378515030 cites W2495647715 @default.
- W4378515030 cites W2509198413 @default.
- W4378515030 cites W2521567534 @default.
- W4378515030 cites W2569437366 @default.
- W4378515030 cites W2608586744 @default.
- W4378515030 cites W2751768647 @default.
- W4378515030 cites W2752514371 @default.
- W4378515030 cites W2770779128 @default.
- W4378515030 cites W2783600151 @default.
- W4378515030 cites W2794856367 @default.
- W4378515030 cites W2904256584 @default.
- W4378515030 cites W2914228934 @default.
- W4378515030 cites W2921971526 @default.
- W4378515030 cites W2945352426 @default.
- W4378515030 cites W2965263362 @default.
- W4378515030 cites W2967743497 @default.
- W4378515030 cites W2968466419 @default.
- W4378515030 cites W2969988482 @default.
- W4378515030 cites W2982594097 @default.
- W4378515030 cites W3001475734 @default.
- W4378515030 cites W3004430113 @default.
- W4378515030 cites W3007018195 @default.
- W4378515030 cites W3027808787 @default.
- W4378515030 cites W3037771224 @default.
- W4378515030 cites W3042746253 @default.
- W4378515030 cites W3104261526 @default.
- W4378515030 cites W3119429075 @default.
- W4378515030 cites W3127816424 @default.
- W4378515030 cites W3130908611 @default.
- W4378515030 cites W3133454995 @default.
- W4378515030 cites W3133895118 @default.
- W4378515030 cites W3136156484 @default.