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- W4378515157 endingPage "8504" @default.
- W4378515157 startingPage "8504" @default.
- W4378515157 abstract "The current study continues the evaluation of the anticancer potential of three de novo synthesized pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides—MM129, MM130, and MM131—against human cancer cells of HeLa, HCT 116, PC-3, and BxPC-3 lines. The pro-apoptotic activity of the investigated sulfonamides was shown by observations of changes in the mitochondrial transmembrane potential of the tested cells, externalization of phosphatidylserine on the cellular membrane surface, and cell morphology in microscopic imaging. The computational studies have shown that MM129 exhibited the lowest binding energy values when docked against CDK enzymes. In addition, the highest stability was shown for complexes formed between MM129 and CDK5/8 enzymes. All examined compounds induced cell cycle arrest in the G0/G1 phase in the BxPC-3 and PC-3 cells and simultaneously caused the accumulation of cells in the S phase in the HCT 116 cells. In addition, the increase in the subG1 fraction was observed in PC-3 and HeLa cells. The application of a fluorescent H2DCFDA probe revealed the high pro-oxidative properties of the tested triazine derivatives, especially MM131. In conclusion, the obtained results suggest that MM129, MM130, and MM131 exhibited strong pro-apoptotic properties towards investigated cells, mainly against the HeLa and HCT 116 cell lines, and high pro-oxidative potential as well. Moreover, it is suggested that the anticancer activity of the tested compounds may be associated with their ability to inhibit CDK enzymes activities." @default.
- W4378515157 created "2023-05-28" @default.
- W4378515157 creator A5004038047 @default.
- W4378515157 creator A5008965047 @default.
- W4378515157 creator A5067813322 @default.
- W4378515157 creator A5069468545 @default.
- W4378515157 creator A5071855983 @default.
- W4378515157 creator A5089577735 @default.
- W4378515157 date "2023-05-09" @default.
- W4378515157 modified "2023-09-30" @default.
- W4378515157 title "Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as Novel Potential Anticancer Agents: Apoptosis, Oxidative Stress, and Cell Cycle Analysis" @default.
- W4378515157 cites W1488165686 @default.
- W4378515157 cites W183556408 @default.
- W4378515157 cites W1851763797 @default.
- W4378515157 cites W1971967721 @default.
- W4378515157 cites W1972711776 @default.
- W4378515157 cites W1974075993 @default.
- W4378515157 cites W1978676346 @default.
- W4378515157 cites W1985184275 @default.
- W4378515157 cites W1986693601 @default.
- W4378515157 cites W1990098732 @default.
- W4378515157 cites W1991199800 @default.
- W4378515157 cites W1995788690 @default.
- W4378515157 cites W2010243701 @default.
- W4378515157 cites W2017455950 @default.
- W4378515157 cites W2018789931 @default.
- W4378515157 cites W2021505095 @default.
- W4378515157 cites W2029080338 @default.
- W4378515157 cites W2031646822 @default.
- W4378515157 cites W2031953074 @default.
- W4378515157 cites W2032463878 @default.
- W4378515157 cites W2046024621 @default.
- W4378515157 cites W2049059336 @default.
- W4378515157 cites W2051927740 @default.
- W4378515157 cites W2057500222 @default.
- W4378515157 cites W2058493730 @default.
- W4378515157 cites W2059683048 @default.
- W4378515157 cites W2062897750 @default.
- W4378515157 cites W2067970470 @default.
- W4378515157 cites W2075567933 @default.
- W4378515157 cites W2076124515 @default.
- W4378515157 cites W2076134807 @default.
- W4378515157 cites W2077217951 @default.
- W4378515157 cites W2078532650 @default.
- W4378515157 cites W2081994183 @default.
- W4378515157 cites W2083433702 @default.
- W4378515157 cites W2089353165 @default.
- W4378515157 cites W2097259163 @default.
- W4378515157 cites W2100467443 @default.
- W4378515157 cites W2101475722 @default.
- W4378515157 cites W2110891265 @default.
- W4378515157 cites W2115708356 @default.
- W4378515157 cites W2120709000 @default.
- W4378515157 cites W2121836670 @default.
- W4378515157 cites W2129334913 @default.
- W4378515157 cites W2132075910 @default.
- W4378515157 cites W2132352483 @default.
- W4378515157 cites W2151323225 @default.
- W4378515157 cites W2156157871 @default.
- W4378515157 cites W2157184985 @default.
- W4378515157 cites W2169927110 @default.
- W4378515157 cites W2171352366 @default.
- W4378515157 cites W2204380965 @default.
- W4378515157 cites W2298046728 @default.
- W4378515157 cites W2301131921 @default.
- W4378515157 cites W2313855869 @default.
- W4378515157 cites W2330815177 @default.
- W4378515157 cites W2388616401 @default.
- W4378515157 cites W2519786994 @default.
- W4378515157 cites W2530562932 @default.
- W4378515157 cites W2548469661 @default.
- W4378515157 cites W2557803615 @default.
- W4378515157 cites W2606842181 @default.
- W4378515157 cites W269249036 @default.
- W4378515157 cites W2794126158 @default.
- W4378515157 cites W2799552155 @default.
- W4378515157 cites W2806296092 @default.
- W4378515157 cites W2884908197 @default.
- W4378515157 cites W2896573423 @default.
- W4378515157 cites W2906120852 @default.
- W4378515157 cites W2936654574 @default.
- W4378515157 cites W2937346106 @default.
- W4378515157 cites W2965701656 @default.
- W4378515157 cites W2979506453 @default.
- W4378515157 cites W2979851191 @default.
- W4378515157 cites W2990468428 @default.
- W4378515157 cites W2991554569 @default.
- W4378515157 cites W2995708286 @default.
- W4378515157 cites W3004118171 @default.
- W4378515157 cites W3005689864 @default.
- W4378515157 cites W3009806530 @default.
- W4378515157 cites W3010714596 @default.
- W4378515157 cites W3012258862 @default.
- W4378515157 cites W3038795160 @default.
- W4378515157 cites W3044218834 @default.
- W4378515157 cites W3046705933 @default.
- W4378515157 cites W3083215673 @default.
- W4378515157 cites W3098741364 @default.