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• W4378515820 endingPage "1405" @default.
• W4378515820 startingPage "1405" @default.
• W4378515820 abstract "Atypical antipsychotics currently constitute the first-line medication for schizophrenia, with quetiapine being one of the most commonly prescribed representatives of the group. Along with its specific affinity for multiple receptors, this compound exerts other biological characteristics, among which anti-inflammatory effects are strongly suggested. Simultaneously, published data indicated that inflammation and microglial activation could be diminished by stimulation of the CD200 receptor (CD200R), which takes place by binding to its ligand (CD200) or soluble CD200 fusion protein (CD200Fc). Therefore, in the present study, we sought to evaluate whether quetiapine could affect certain aspects of microglial activity, including the CD200-CD200R and CX3CL1-CX3CR1 axes, which are involved in the regulation of neuron-microglia interactions, as well as the expression of selected markers of the pro- and anti-inflammatory profile of microglia (Cd40, Il-1β, Il-6, Cebpb, Cd206, Arg1, Il-10 and Tgf-β). Concurrently, we examined the impact of quetiapine and CD200Fc on the IL-6 and IL-10 protein levels. The abovementioned aspects were investigated in organotypic cortical cultures (OCCs) prepared from the offspring of control rats (control OCCs) or those subjected to maternal immune activation (MIA OCCs), which is a widely implemented approach to explore schizophrenia-like disturbances in animals. The experiments were performed under basal conditions and after additional exposure to the bacterial endotoxin lipopolysaccharide (LPS), according to the two-hit hypothesis of schizophrenia. The results of our research revealed differences between control and MIA OCCs under basal conditions and in response to treatment with LPS in terms of lactate dehydrogenase and nitric oxide release as well as Cd200r, Il-1β, Il-6 and Cd206 expression. The additional stimulation with the bacterial endotoxin resulted in a notable change in the mRNA levels of pro- and anti-inflammatory microglial markers in both types of OCCs. Quetiapine diminished the influence of LPS on Il-1β, Il-6, Cebpb and Arg1 expression in control OCCs as well as on IL-6 and IL-10 levels in MIA OCCs. Moreover, CD200Fc reduced the impact of the bacterial endotoxin on IL-6 production in MIA OCCs. Thus, our results demonstrated that quetiapine, as well as the stimulation of CD200R by CD200Fc, beneficially affected LPS-induced neuroimmunological changes, including microglia-related activation." @default.
• W4378515820 created "2023-05-28" @default.
• W4378515820 creator A5004924903 @default.
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• W4378515820 creator A5085933249 @default.
• W4378515820 creator A5089373781 @default.
• W4378515820 date "2023-05-09" @default.
• W4378515820 modified "2023-10-18" @default.
• W4378515820 title "Insights into the Potential Impact of Quetiapine on the Microglial Trajectory and Inflammatory Response in Organotypic Cortical Cultures Derived from Rat Offspring" @default.
• W4378515820 cites W1112818150 @default.
• W4378515820 cites W1485248315 @default.
• W4378515820 cites W1496231157 @default.
• W4378515820 cites W1785970105 @default.
• W4378515820 cites W1891863012 @default.
• W4378515820 cites W193921704 @default.
• W4378515820 cites W1954777573 @default.
• W4378515820 cites W1968675910 @default.
• W4378515820 cites W1969938632 @default.
• W4378515820 cites W1972879829 @default.
• W4378515820 cites W1974886157 @default.
• W4378515820 cites W1975153271 @default.
• W4378515820 cites W1976114987 @default.
• W4378515820 cites W1983220630 @default.
• W4378515820 cites W1987830851 @default.
• W4378515820 cites W1993575968 @default.
• W4378515820 cites W1995760805 @default.
• W4378515820 cites W2001941062 @default.
• W4378515820 cites W2007305673 @default.
• W4378515820 cites W2009832071 @default.
• W4378515820 cites W2028249314 @default.
• W4378515820 cites W2028321082 @default.
• W4378515820 cites W2030345783 @default.
• W4378515820 cites W2039357236 @default.
• W4378515820 cites W2043457317 @default.
• W4378515820 cites W2048672635 @default.
• W4378515820 cites W2065494319 @default.
• W4378515820 cites W2079054696 @default.
• W4378515820 cites W2091865768 @default.
• W4378515820 cites W2092623647 @default.
• W4378515820 cites W2093470593 @default.
• W4378515820 cites W2097147259 @default.
• W4378515820 cites W2112039060 @default.
• W4378515820 cites W2114678425 @default.
• W4378515820 cites W2129321699 @default.
• W4378515820 cites W2131966414 @default.
• W4378515820 cites W2147221923 @default.
• W4378515820 cites W2148399348 @default.
• W4378515820 cites W2151241903 @default.
• W4378515820 cites W2153426813 @default.
• W4378515820 cites W2158627911 @default.
• W4378515820 cites W2161899228 @default.
• W4378515820 cites W2218409913 @default.
• W4378515820 cites W2295298792 @default.
• W4378515820 cites W2325471368 @default.
• W4378515820 cites W2466329687 @default.
• W4378515820 cites W2515897135 @default.
• W4378515820 cites W2559415043 @default.
• W4378515820 cites W25956716 @default.
• W4378515820 cites W2613925863 @default.
• W4378515820 cites W2614896896 @default.
• W4378515820 cites W2617293585 @default.
• W4378515820 cites W2766082103 @default.
• W4378515820 cites W2797156330 @default.
• W4378515820 cites W2888342366 @default.
• W4378515820 cites W2890708734 @default.
• W4378515820 cites W2893505137 @default.
• W4378515820 cites W2896119916 @default.
• W4378515820 cites W2902460584 @default.
• W4378515820 cites W2914323200 @default.
• W4378515820 cites W2916976520 @default.
• W4378515820 cites W2921401018 @default.
• W4378515820 cites W2944284771 @default.
• W4378515820 cites W2950021647 @default.
• W4378515820 cites W2950735773 @default.
• W4378515820 cites W2958423778 @default.
• W4378515820 cites W2987389202 @default.
• W4378515820 cites W2991550208 @default.
• W4378515820 cites W3002901929 @default.
• W4378515820 cites W3041763228 @default.
• W4378515820 cites W3063857002 @default.
• W4378515820 cites W3081072475 @default.
• W4378515820 cites W3081365535 @default.
• W4378515820 cites W3092594560 @default.
• W4378515820 cites W3109295064 @default.
• W4378515820 cites W3128917755 @default.
• W4378515820 cites W3138397487 @default.
• W4378515820 cites W3167037214 @default.
• W4378515820 cites W37545008 @default.
• W4378515820 cites W4224305558 @default.
• W4378515820 cites W4255225298 @default.
• W4378515820 cites W4256142660 @default.
• W4378515820 cites W4293276053 @default.
• W4378515820 cites W4294884242 @default.
• W4378515820 cites W4295106632 @default.

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