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- W4378516586 endingPage "1411" @default.
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- W4378516586 abstract "Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia. Despite numerous studies, the etiology of Alzheimer's disease remains incompletely known, as the pathological accumulation of amyloid beta aggregates cannot fully explain the complex clinical picture of the disease. Or, for the development of effective therapies, it is mandatory to understand the roles of amyloid beta at the brain level, from its initial monomeric stage prior to aggregation in the form of senile plaques. In this sense, this review aims to bring new, clinically relevant data on a subject intensely debated in the literature in the last years. In the first part, the amyloidogenic cascade is reviewed and the possible subtypes of amyloid beta are differentiated. In the second part, the roles played by the amyloid beta monomers in physiological and pathological (neurodegenerative) conditions are illustrated based on the most relevant and recent studies published on this topic. Finally, considering the importance of amyloid beta monomers in the pathophysiology of Alzheimer's disease, new research directions with diagnostic and therapeutic impacts are suggested." @default.
- W4378516586 created "2023-05-28" @default.
- W4378516586 creator A5005227049 @default.
- W4378516586 creator A5035504241 @default.
- W4378516586 creator A5052936466 @default.
- W4378516586 creator A5067969017 @default.
- W4378516586 date "2023-05-10" @default.
- W4378516586 modified "2023-10-18" @default.
- W4378516586 title "The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions" @default.
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