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- W4378528023 abstract "Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. Despite the significant progress in cancer diagnosis and treatment over the last few years, the approach to disease detection and therapy still does not include histopathological biomarkers. The dissemination of PCa is strictly related to the creation of a premetastatic niche, which can be detected by altered levels of specific biomarkers. To date, the risk factors for biochemical recurrence include lymph node status, prostate-specific antigen (PSA), PSA density (PSAD), body mass index (BMI), pathological Gleason score, seminal vesicle invasion, extraprostatic extension, and intraductal carcinoma. In the future, biomarkers might represent another prognostic factor, as discussed in many studies. In this review, we focus on histopathological biomarkers (particularly CD169 macrophages, neuropilin-1, cofilin-1, interleukin-17, signal transducer and activator of transcription protein 3 (STAT3), LIM domain kinase 1 (LIMK1), CD15, AMACR, prostate-specific membrane antigen (PSMA), Appl1, Sortilin, Syndecan-1, and p63) and their potential application in decision making regarding the prognosis and treatment of PCa patients. We refer to studies that found a correlation between the levels of biomarkers and tumor characteristics as well as clinical outcomes. We also hypothesize about the potential use of histopathological markers as a target for novel immunotherapeutic drugs or targeted radionuclide therapy, which may be used as adjuvant therapy in the future." @default.
- W4378528023 created "2023-05-28" @default.
- W4378528023 creator A5012396827 @default.
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- W4378528023 creator A5073181265 @default.
- W4378528023 creator A5075197203 @default.
- W4378528023 date "2023-05-26" @default.
- W4378528023 modified "2023-10-16" @default.
- W4378528023 title "Novel Histopathological Biomarkers in Prostate Cancer: Implications and Perspectives" @default.
- W4378528023 cites W1536242272 @default.
- W4378528023 cites W1660230969 @default.
- W4378528023 cites W1757407923 @default.
- W4378528023 cites W1789272384 @default.
- W4378528023 cites W1851243469 @default.
- W4378528023 cites W1899851581 @default.
- W4378528023 cites W1917894041 @default.
- W4378528023 cites W1948284414 @default.
- W4378528023 cites W1951240240 @default.
- W4378528023 cites W1954449319 @default.
- W4378528023 cites W1965462445 @default.
- W4378528023 cites W1965831940 @default.
- W4378528023 cites W1966056172 @default.
- W4378528023 cites W1966789656 @default.
- W4378528023 cites W1969163394 @default.
- W4378528023 cites W1969797826 @default.
- W4378528023 cites W1970039562 @default.
- W4378528023 cites W1970987838 @default.
- W4378528023 cites W1971033232 @default.
- W4378528023 cites W1973008001 @default.
- W4378528023 cites W1974502272 @default.
- W4378528023 cites W1977388865 @default.
- W4378528023 cites W1977818137 @default.
- W4378528023 cites W1982334431 @default.
- W4378528023 cites W1982540283 @default.
- W4378528023 cites W1987375206 @default.
- W4378528023 cites W1987942705 @default.
- W4378528023 cites W1994465944 @default.
- W4378528023 cites W1995475980 @default.
- W4378528023 cites W1995602018 @default.
- W4378528023 cites W1996801596 @default.
- W4378528023 cites W1998923122 @default.
- W4378528023 cites W2000405871 @default.
- W4378528023 cites W2000859725 @default.
- W4378528023 cites W2001108463 @default.
- W4378528023 cites W2001314112 @default.
- W4378528023 cites W2001475156 @default.
- W4378528023 cites W2004349741 @default.
- W4378528023 cites W2004881559 @default.
- W4378528023 cites W2007040235 @default.
- W4378528023 cites W2007081354 @default.
- W4378528023 cites W2007739717 @default.
- W4378528023 cites W2008692337 @default.
- W4378528023 cites W2009359714 @default.
- W4378528023 cites W2014002033 @default.
- W4378528023 cites W2014153856 @default.
- W4378528023 cites W2017117774 @default.
- W4378528023 cites W2017715430 @default.
- W4378528023 cites W2017995578 @default.
- W4378528023 cites W2021766591 @default.
- W4378528023 cites W2024173356 @default.
- W4378528023 cites W2025649858 @default.
- W4378528023 cites W2026190214 @default.
- W4378528023 cites W2027253055 @default.
- W4378528023 cites W2028505287 @default.
- W4378528023 cites W2028544780 @default.
- W4378528023 cites W2030112489 @default.
- W4378528023 cites W2031268426 @default.
- W4378528023 cites W2032287776 @default.
- W4378528023 cites W2032297742 @default.
- W4378528023 cites W2034236055 @default.
- W4378528023 cites W2034245637 @default.
- W4378528023 cites W2035936829 @default.
- W4378528023 cites W2040831260 @default.
- W4378528023 cites W2042349690 @default.
- W4378528023 cites W2044114076 @default.
- W4378528023 cites W2044227662 @default.
- W4378528023 cites W2046285899 @default.
- W4378528023 cites W2052408383 @default.
- W4378528023 cites W2053535373 @default.
- W4378528023 cites W2053968039 @default.
- W4378528023 cites W2058072908 @default.
- W4378528023 cites W2058610836 @default.
- W4378528023 cites W2060537954 @default.
- W4378528023 cites W2060638571 @default.
- W4378528023 cites W2063143301 @default.
- W4378528023 cites W2066561373 @default.
- W4378528023 cites W2066867399 @default.
- W4378528023 cites W2066867563 @default.
- W4378528023 cites W2067488129 @default.
- W4378528023 cites W2075015725 @default.
- W4378528023 cites W2075165459 @default.
- W4378528023 cites W2081111239 @default.
- W4378528023 cites W2081206938 @default.
- W4378528023 cites W2081287664 @default.