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- W4378528038 endingPage "1560" @default.
- W4378528038 startingPage "1560" @default.
- W4378528038 abstract "The enteric nervous system (ENS) is a nerve network composed of neurons and glial cells that regulates the motor and secretory functions of the gastrointestinal (GI) tract. There is abundant evidence of mutual communication between the brain and the GI tract. Dysfunction of these connections appears to be involved in the pathophysiology of Parkinson's disease (PD). Alterations in the ENS have been shown to occur very early in PD, even before central nervous system (CNS) involvement. Post-mortem studies of PD patients have shown aggregation of α-synuclein (αS) in specific subtypes of neurons in the ENS. Subsequently, αS spreads retrogradely in the CNS through preganglionic vagal fibers to this nerve's dorsal motor nucleus (DMV) and other central nervous structures. Here, we highlight the role of the ENS in PD pathogenesis based on evidence observed in animal models and using a translational perspective. While acknowledging the putative role of the microbiome in the gut-brain axis (GBA), this review provides a comprehensive view of the ENS not only as a second brain, but also as a window into the first brain, a potentially crucial element in the search for new therapeutic approaches that can delay and even cure the disease." @default.
- W4378528038 created "2023-05-28" @default.
- W4378528038 creator A5009525774 @default.
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- W4378528038 creator A5038770696 @default.
- W4378528038 creator A5077188397 @default.
- W4378528038 creator A5086329377 @default.
- W4378528038 date "2023-05-27" @default.
- W4378528038 modified "2023-10-05" @default.
- W4378528038 title "Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human" @default.
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