FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378528068> ?p ?o ?g. }

• W4378528068 endingPage "701" @default.
• W4378528068 startingPage "701" @default.
• W4378528068 abstract "Insights into the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness, point towards a complex interplay of genetic and lifestyle factors triggering various systemic pathways. This study aimed to characterize metabolomic profiles for AMD and to evaluate their position in the trias with genetics and lifestyle. This study included 5923 individuals from five European studies. Blood metabolomics were assessed using a nuclear magnetic resonance platform of 146 metabolites. Associations were studied using regression analyses. A genetic risk score (GRS) was calculated using β-values of 49 AMD variants, a lifestyle risk score (LRS) using smoking and diet data, and a metabolite risk score (MRS) using metabolite values. We identified 61 metabolites associated with early-intermediate AMD, of which 94% were lipid-related, with higher levels of HDL-subparticles and apolipoprotein-A1, and lower levels of VLDL-subparticles, triglycerides, and fatty acids (false discovery rate (FDR) p-value < 1.4 × 10−2). Late AMD was associated with lower levels of the amino acids histidine, leucine, valine, tyrosine, and phenylalanine, and higher levels of the ketone bodies acetoacetate and 3-hydroxybutyrate (FDR p-value < 1.5 × 10−3). A favorable lifestyle characterized by a healthy diet was associated with higher levels of amino acids and lower levels of ketone bodies, while an unfavorable lifestyle, including smoking, showed opposite effects (FDR p-value < 2.7 × 10−2). The MRS mediated 5% of the effect of the GRS and 20% of that of the LRS on late AMD. Our findings show that metabolomic profiles differ between AMD stages and show that blood metabolites mostly reflect lifestyle. The severity-specific profiles spur further interest into the systemic effects related to disease conversion." @default.
• W4378528068 created "2023-05-28" @default.
• W4378528068 creator A5006640908 @default.
• W4378528068 creator A5015633656 @default.
• W4378528068 creator A5018056670 @default.
• W4378528068 creator A5021919197 @default.
• W4378528068 creator A5029529953 @default.
• W4378528068 creator A5031702329 @default.
• W4378528068 creator A5034780611 @default.
• W4378528068 creator A5042450210 @default.
• W4378528068 creator A5049316980 @default.
• W4378528068 creator A5049656883 @default.
• W4378528068 creator A5079708174 @default.
• W4378528068 creator A5086926273 @default.
• W4378528068 date "2023-05-27" @default.
• W4378528068 modified "2023-09-27" @default.
• W4378528068 title "Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration" @default.
• W4378528068 cites W1558943628 @default.
• W4378528068 cites W1900193133 @default.
• W4378528068 cites W1978462231 @default.
• W4378528068 cites W1997975781 @default.
• W4378528068 cites W2033027030 @default.
• W4378528068 cites W2076029048 @default.
• W4378528068 cites W2096248193 @default.
• W4378528068 cites W2132339674 @default.
• W4378528068 cites W2169718193 @default.
• W4378528068 cites W2169779482 @default.
• W4378528068 cites W2199776059 @default.
• W4378528068 cites W2217807288 @default.
• W4378528068 cites W2233221674 @default.
• W4378528068 cites W2560241007 @default.
• W4378528068 cites W2595778161 @default.
• W4378528068 cites W2609016849 @default.
• W4378528068 cites W2615160023 @default.
• W4378528068 cites W2734721636 @default.
• W4378528068 cites W2756003281 @default.
• W4378528068 cites W2886744986 @default.
• W4378528068 cites W2893512574 @default.
• W4378528068 cites W2896680987 @default.
• W4378528068 cites W2900073858 @default.
• W4378528068 cites W2904931786 @default.
• W4378528068 cites W2905434803 @default.
• W4378528068 cites W2907178429 @default.
• W4378528068 cites W2914322159 @default.
• W4378528068 cites W2941365584 @default.
• W4378528068 cites W2952316104 @default.
• W4378528068 cites W2954489538 @default.
• W4378528068 cites W2978000171 @default.
• W4378528068 cites W3016124644 @default.
• W4378528068 cites W3019130036 @default.
• W4378528068 cites W3023035004 @default.
• W4378528068 cites W3035286545 @default.
• W4378528068 cites W3045210430 @default.
• W4378528068 cites W3047846143 @default.
• W4378528068 cites W3093235155 @default.
• W4378528068 cites W3103189346 @default.
• W4378528068 cites W3106584974 @default.
• W4378528068 cites W3110220146 @default.
• W4378528068 cites W3111471141 @default.
• W4378528068 cites W3138102461 @default.
• W4378528068 cites W3170813075 @default.
• W4378528068 cites W4205506897 @default.
• W4378528068 doi "https://doi.org/10.3390/metabo13060701" @default.
• W4378528068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37367859" @default.
• W4378528068 hasPublicationYear "2023" @default.
• W4378528068 type Work @default.
• W4378528068 citedByCount "0" @default.
• W4378528068 crossrefType "journal-article" @default.
• W4378528068 hasAuthorship W4378528068A5006640908 @default.
• W4378528068 hasAuthorship W4378528068A5015633656 @default.
• W4378528068 hasAuthorship W4378528068A5018056670 @default.
• W4378528068 hasAuthorship W4378528068A5021919197 @default.
• W4378528068 hasAuthorship W4378528068A5029529953 @default.
• W4378528068 hasAuthorship W4378528068A5031702329 @default.
• W4378528068 hasAuthorship W4378528068A5034780611 @default.
• W4378528068 hasAuthorship W4378528068A5042450210 @default.
• W4378528068 hasAuthorship W4378528068A5049316980 @default.
• W4378528068 hasAuthorship W4378528068A5049656883 @default.
• W4378528068 hasAuthorship W4378528068A5079708174 @default.
• W4378528068 hasAuthorship W4378528068A5086926273 @default.
• W4378528068 hasBestOaLocation W43785280681 @default.
• W4378528068 hasConcept C118487528 @default.
• W4378528068 hasConcept C126322002 @default.
• W4378528068 hasConcept C134018914 @default.
• W4378528068 hasConcept C21565614 @default.
• W4378528068 hasConcept C2776403814 @default.
• W4378528068 hasConcept C2777477808 @default.
• W4378528068 hasConcept C2777573094 @default.
• W4378528068 hasConcept C42407357 @default.
• W4378528068 hasConcept C515207424 @default.
• W4378528068 hasConcept C54355233 @default.
• W4378528068 hasConcept C60644358 @default.
• W4378528068 hasConcept C71924100 @default.
• W4378528068 hasConcept C86803240 @default.
• W4378528068 hasConceptScore W4378528068C118487528 @default.
• W4378528068 hasConceptScore W4378528068C126322002 @default.
• W4378528068 hasConceptScore W4378528068C134018914 @default.
• W4378528068 hasConceptScore W4378528068C21565614 @default.

• next