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- W4378530731 abstract "Introduction New non-steroidal topical agents are needed for the treatment of psoriasis. Roflumilast cream 0.3% is a once daily phosphodiesterase-4 inhibitor that was recently approved by the FDA for the treatment of plaque psoriasis in adolescents and adults. It is indicated for use on all body surfaces including intertriginous areas.Areas covered In this review, we summarize the current knowledge about roflumilast cream for the treatment of psoriasis, highlighting its efficacy and safety profile from published clinical trials. Roflumilast’s mechanism of action and pharmacokinetic profile are also discussed.Expert opinion Positive results were reported across trials with 48% of patients treated with roflumilast achieving an Investigator Global Assessment score of clear or almost clear at 8 weeks in phase III studies. Most adverse events were mild or moderate in severity and few application-site reactions were reported among participants. Unique advantages of the cream are its success in treating intertriginous areas and its ability to reduce symptoms of itch, results of which may significantly improve quality of life for patients. In the future, real-world data and active comparator trials with existing non-steroidal agents are needed to better understand roflumilast’s place in the current treatment landscape." @default.
- W4378530731 created "2023-05-28" @default.
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- W4378530731 date "2023-05-30" @default.
- W4378530731 modified "2023-10-14" @default.
- W4378530731 title "Topical roflumilast for the treatment of psoriasis" @default.
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- W4378530731 doi "https://doi.org/10.1080/1744666x.2023.2219897" @default.
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