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• W4378549577 abstract "Objective To determine how frequently competing risks were accounted for in recently published cardiovascular disease (CVD) trials with composite end points. Study Design and Setting We conducted a methodological survey of CVD trials that used composite end points and published from January 1 to September 27, 2021. The following databases were searched: PubMed, Medline, Embase, CINAHL, and Web of Science. Eligible studies were categorized according to whether they mentioned a competing risk analysis plan. If yes, whether a competing risk analysis was proposed as the primary or sensitivity analysis. Results Among the 136 included studies, only 14 (10.3%) conducted a competing risk analysis and reported the corresponding results. Seven (50%) of them conducted a competing risk analysis as their primary analysis, whereas the other seven (50%) as a sensitivity analysis to assess the robustness of their findings. The most commonly used competing risk analysis methods were the subdistribution hazard model (nine studies), followed by the cause-specific hazard model (four studies) and restricted mean time lost method (one study). None of the studies accounted for competing risks in their sample size calculations. Conclusion Our findings underscore the pressing need for and importance of applying appropriate competing risk analysis in this field to disseminate clinically meaningful and unbiased results." @default.
• W4378549577 created "2023-05-28" @default.
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• W4378549577 date "2023-08-01" @default.
• W4378549577 modified "2023-10-18" @default.
• W4378549577 title "Trials using composite outcomes neglect the presence of competing risks: a methodological survey of cardiovascular studies" @default.
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• W4378549577 doi "https://doi.org/10.1016/j.jclinepi.2023.05.015" @default.
• W4378549577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37245700" @default.
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