FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378549665> ?p ?o ?g. }

• W4378549665 endingPage "118" @default.
• W4378549665 startingPage "109" @default.
• W4378549665 abstract "Skeletal progenitor: collagen interactions are critical for bone development and regeneration. Both collagen-binding integrins and discoidin domain receptors (DDR1 and DDR2) function as collagen receptors in bone. Each receptor is activated by a distinct collagen sequence; GFOGER for integrins and GVMGFO for DDRs. Specific triple helical peptides containing each of these binding domains were evaluated for ability to stimulate DDR2 and integrin signaling and osteoblast differentiation. GVMGFO peptide stimulated DDR2 Y740 phosphorylation and osteoblast differentiation as measured by induction of osteoblast marker mRNAs and mineralization without affecting integrin activity. In contrast, GFOGER peptide stimulated focal adhesion kinase (FAK) Y397 phosphorylation, an early measure of integrin activation, and to a lesser extent osteoblast differentiation without affecting DDR2-P. Significantly, the combination of both peptides cooperatively enhanced both DDR2 and FAK signaling and osteoblast differentiation, a response that was blocked in Ddr2-deficient cells. These studies suggest that the development of scaffolds containing DDR and integrin-activating peptides may provide a new route for promoting bone regeneration. A method for stimulating osteoblast differentiation of skeletal progenitor cells is described that uses culture surfaces coated with a collagen-derived triple-helical peptide to selectively activate discoidin domain receptors. When this peptide is combined with an integrin-activating peptide, synergistic stimulation of differentiation is seen. This approach of combining collagen-derived peptides to stimulate the two main collagen receptors in bone (DDR2 and collagen-binding integrins) provides a route for developing a new class of tissue engineering scaffolds for bone regeneration." @default.
• W4378549665 created "2023-05-28" @default.
• W4378549665 creator A5018365310 @default.
• W4378549665 creator A5032302705 @default.
• W4378549665 creator A5068805457 @default.
• W4378549665 creator A5078269327 @default.
• W4378549665 creator A5086114121 @default.
• W4378549665 date "2023-08-01" @default.
• W4378549665 modified "2023-10-16" @default.
• W4378549665 title "Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells" @default.
• W4378549665 cites W1972354309 @default.
• W4378549665 cites W1973863009 @default.
• W4378549665 cites W1976772770 @default.
• W4378549665 cites W1980106834 @default.
• W4378549665 cites W1996268016 @default.
• W4378549665 cites W2000307793 @default.
• W4378549665 cites W2000463542 @default.
• W4378549665 cites W2005338270 @default.
• W4378549665 cites W2010439076 @default.
• W4378549665 cites W2019624372 @default.
• W4378549665 cites W2026269197 @default.
• W4378549665 cites W2038840924 @default.
• W4378549665 cites W2040479916 @default.
• W4378549665 cites W2047500306 @default.
• W4378549665 cites W2051926344 @default.
• W4378549665 cites W2080676609 @default.
• W4378549665 cites W2106541600 @default.
• W4378549665 cites W2119071014 @default.
• W4378549665 cites W2146857985 @default.
• W4378549665 cites W2149697928 @default.
• W4378549665 cites W2151776485 @default.
• W4378549665 cites W2168181903 @default.
• W4378549665 cites W2171866804 @default.
• W4378549665 cites W2184894459 @default.
• W4378549665 cites W2190887510 @default.
• W4378549665 cites W2463417538 @default.
• W4378549665 cites W2607906940 @default.
• W4378549665 cites W2800987704 @default.
• W4378549665 cites W2901865264 @default.
• W4378549665 cites W2947902964 @default.
• W4378549665 cites W2999012858 @default.
• W4378549665 cites W2999129511 @default.
• W4378549665 cites W3010441270 @default.
• W4378549665 cites W3031835899 @default.
• W4378549665 cites W3090678864 @default.
• W4378549665 cites W3111021487 @default.
• W4378549665 cites W3158465443 @default.
• W4378549665 cites W4210943377 @default.
• W4378549665 cites W4214885006 @default.
• W4378549665 cites W4285801329 @default.
• W4378549665 cites W4317479295 @default.
• W4378549665 doi "https://doi.org/10.1016/j.actbio.2023.05.039" @default.
• W4378549665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37245640" @default.
• W4378549665 hasPublicationYear "2023" @default.
• W4378549665 type Work @default.
• W4378549665 citedByCount "1" @default.
• W4378549665 countsByYear W43785496652023 @default.
• W4378549665 crossrefType "journal-article" @default.
• W4378549665 hasAuthorship W4378549665A5018365310 @default.
• W4378549665 hasAuthorship W4378549665A5032302705 @default.
• W4378549665 hasAuthorship W4378549665A5068805457 @default.
• W4378549665 hasAuthorship W4378549665A5078269327 @default.
• W4378549665 hasAuthorship W4378549665A5086114121 @default.
• W4378549665 hasConcept C101544691 @default.
• W4378549665 hasConcept C119524353 @default.
• W4378549665 hasConcept C11960822 @default.
• W4378549665 hasConcept C152681006 @default.
• W4378549665 hasConcept C170493617 @default.
• W4378549665 hasConcept C185592680 @default.
• W4378549665 hasConcept C192562407 @default.
• W4378549665 hasConcept C195687474 @default.
• W4378549665 hasConcept C201750760 @default.
• W4378549665 hasConcept C202751555 @default.
• W4378549665 hasConcept C2776305115 @default.
• W4378549665 hasConcept C2778260815 @default.
• W4378549665 hasConcept C28328180 @default.
• W4378549665 hasConcept C55493867 @default.
• W4378549665 hasConcept C86803240 @default.
• W4378549665 hasConcept C95444343 @default.
• W4378549665 hasConceptScore W4378549665C101544691 @default.
• W4378549665 hasConceptScore W4378549665C119524353 @default.
• W4378549665 hasConceptScore W4378549665C11960822 @default.
• W4378549665 hasConceptScore W4378549665C152681006 @default.
• W4378549665 hasConceptScore W4378549665C170493617 @default.
• W4378549665 hasConceptScore W4378549665C185592680 @default.
• W4378549665 hasConceptScore W4378549665C192562407 @default.
• W4378549665 hasConceptScore W4378549665C195687474 @default.
• W4378549665 hasConceptScore W4378549665C201750760 @default.
• W4378549665 hasConceptScore W4378549665C202751555 @default.
• W4378549665 hasConceptScore W4378549665C2776305115 @default.
• W4378549665 hasConceptScore W4378549665C2778260815 @default.
• W4378549665 hasConceptScore W4378549665C28328180 @default.
• W4378549665 hasConceptScore W4378549665C55493867 @default.
• W4378549665 hasConceptScore W4378549665C86803240 @default.
• W4378549665 hasConceptScore W4378549665C95444343 @default.
• W4378549665 hasFunder F4320306078 @default.
• W4378549665 hasFunder F4320332161 @default.
• W4378549665 hasLocation W43785496651 @default.

• next