Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378575209> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4378575209 abstract "Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. However, the role of metformin in either inducing autophagy and cisplatin-resistance of human gastric cancer (GC) cells has never been examined. The study has established a cisplatin-resistant GC cell line and investigated the effects of metformin on inducing autophagy on it. The results demonstrated that treatment with metformin can concentration-dependently suppress the cell viability and cell confluence of cisplatin-resistant GC cells, while having no effects on human primary stomach epithelial cells (HPSEC). For the first time, we found that metformin can significantly increase the acidic vesicular organelles (AVO) level and decrease the acridine orange (AO) level spontaneously in the cisplatin-resistant GC cells. Thus, we further checked the other markers, Atg5, Atg12 and LC3-II, which showed that metformin indeed induced autophagy in the cisplatin-resistant GC cells. In addition, treatment of 3-Methyladenine (3-MA) can significantly rescue the metformin-induced autophagy. At the same time, metformin can induce the alterations of apoptosis-associated signal molecules, such as caspase-3 and caspase-7 activities. Overall, the pilot study provided evidence for metformin induced autophagy in addition to apoptosis, making it as an effective anticancer drug for the therapy of cisplatin-resistant GC. Killing the cisplatin-resistant GC cells with non-toxic metformin via both autophagy and apoptosis might extend its usefulness in our fighting with chemo-resistance of gastric cancer cells." @default.
- W4378575209 created "2023-05-28" @default.
- W4378575209 creator A5003209250 @default.
- W4378575209 creator A5020090589 @default.
- W4378575209 creator A5030324810 @default.
- W4378575209 creator A5039254218 @default.
- W4378575209 creator A5061033027 @default.
- W4378575209 creator A5063084988 @default.
- W4378575209 creator A5072558939 @default.
- W4378575209 date "2023-05-26" @default.
- W4378575209 modified "2023-09-30" @default.
- W4378575209 title "Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis" @default.
- W4378575209 doi "https://doi.org/10.37796/2211-8039.1408" @default.
- W4378575209 hasPublicationYear "2023" @default.
- W4378575209 type Work @default.
- W4378575209 citedByCount "0" @default.
- W4378575209 crossrefType "journal-article" @default.
- W4378575209 hasAuthorship W4378575209A5003209250 @default.
- W4378575209 hasAuthorship W4378575209A5020090589 @default.
- W4378575209 hasAuthorship W4378575209A5030324810 @default.
- W4378575209 hasAuthorship W4378575209A5039254218 @default.
- W4378575209 hasAuthorship W4378575209A5061033027 @default.
- W4378575209 hasAuthorship W4378575209A5063084988 @default.
- W4378575209 hasAuthorship W4378575209A5072558939 @default.
- W4378575209 hasBestOaLocation W43785752091 @default.
- W4378575209 hasConcept C121608353 @default.
- W4378575209 hasConcept C126322002 @default.
- W4378575209 hasConcept C134018914 @default.
- W4378575209 hasConcept C185592680 @default.
- W4378575209 hasConcept C190283241 @default.
- W4378575209 hasConcept C203522944 @default.
- W4378575209 hasConcept C2776694085 @default.
- W4378575209 hasConcept C2777688063 @default.
- W4378575209 hasConcept C2778239845 @default.
- W4378575209 hasConcept C2780323712 @default.
- W4378575209 hasConcept C2781000418 @default.
- W4378575209 hasConcept C502942594 @default.
- W4378575209 hasConcept C55493867 @default.
- W4378575209 hasConcept C555293320 @default.
- W4378575209 hasConcept C71924100 @default.
- W4378575209 hasConcept C96232424 @default.
- W4378575209 hasConcept C98274493 @default.
- W4378575209 hasConceptScore W4378575209C121608353 @default.
- W4378575209 hasConceptScore W4378575209C126322002 @default.
- W4378575209 hasConceptScore W4378575209C134018914 @default.
- W4378575209 hasConceptScore W4378575209C185592680 @default.
- W4378575209 hasConceptScore W4378575209C190283241 @default.
- W4378575209 hasConceptScore W4378575209C203522944 @default.
- W4378575209 hasConceptScore W4378575209C2776694085 @default.
- W4378575209 hasConceptScore W4378575209C2777688063 @default.
- W4378575209 hasConceptScore W4378575209C2778239845 @default.
- W4378575209 hasConceptScore W4378575209C2780323712 @default.
- W4378575209 hasConceptScore W4378575209C2781000418 @default.
- W4378575209 hasConceptScore W4378575209C502942594 @default.
- W4378575209 hasConceptScore W4378575209C55493867 @default.
- W4378575209 hasConceptScore W4378575209C555293320 @default.
- W4378575209 hasConceptScore W4378575209C71924100 @default.
- W4378575209 hasConceptScore W4378575209C96232424 @default.
- W4378575209 hasConceptScore W4378575209C98274493 @default.
- W4378575209 hasIssue "2" @default.
- W4378575209 hasLocation W43785752091 @default.
- W4378575209 hasOpenAccess W4378575209 @default.
- W4378575209 hasPrimaryLocation W43785752091 @default.
- W4378575209 hasRelatedWork W1529324287 @default.
- W4378575209 hasRelatedWork W2034050926 @default.
- W4378575209 hasRelatedWork W2054650618 @default.
- W4378575209 hasRelatedWork W2055396192 @default.
- W4378575209 hasRelatedWork W2176514435 @default.
- W4378575209 hasRelatedWork W2793335552 @default.
- W4378575209 hasRelatedWork W2923024569 @default.
- W4378575209 hasRelatedWork W2989033186 @default.
- W4378575209 hasRelatedWork W3183350915 @default.
- W4378575209 hasRelatedWork W4378575209 @default.
- W4378575209 hasVolume "13" @default.
- W4378575209 isParatext "false" @default.
- W4378575209 isRetracted "false" @default.
- W4378575209 workType "article" @default.