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- W4378575666 abstract "A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified as possibly carcinogenic; however, their biological effects are unclear. As aberrant DNAm of genomic repetitive elements (REs) may promote genomic instability, here, we sought to determine whether exposure to RF-EMFs could affect DNAm of different classes of REs, such as long interspersed nuclear elements-1 (LINE-1), Alu short interspersed nuclear elements and ribosomal repeats. To this purpose, we analysed DNAm profiles of cervical cancer and neuroblastoma cell lines (HeLa, BE(2)C and SH-SY5Y) exposed to 900 MHz GSM-modulated RF-EMF through an Illumina-based targeted deep bisulfite sequencing approach. Our findings showed that radiofrequency exposure did not affect the DNAm of Alu elements in any of the cell lines analysed. Conversely, it influenced DNAm of LINE-1 and ribosomal repeats in terms of both average profiles and organisation of methylated and unmethylated CpG sites, in different ways in each of the three cell lines studied." @default.
- W4378575666 created "2023-05-28" @default.
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- W4378575666 creator A5085261095 @default.
- W4378575666 date "2023-05-27" @default.
- W4378575666 modified "2023-10-16" @default.
- W4378575666 title "Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation" @default.
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- W4378575666 doi "https://doi.org/10.3390/ijms24119380" @default.
- W4378575666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37298336" @default.
- W4378575666 hasPublicationYear "2023" @default.
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