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- W4378575991 abstract "BackgroundStereotactic ablative radiotherapy (SABR) is a treatment option for patients with lung tumors that employs fiducials to track tumors during the breathing cycle. Currently, there is a paucity of data on how relative fiducial location and patient clinical characteristics impact fiducial tracking and clinical outcomes. This study aims to identify factors that reduce the number of fiducials tracked with respiratory motion management during SABR.MethodsAn IRB approved retrospective review was performed on patients receiving robotic SABR for lung tumors at our institution from 2016 to 2019. Clinical data including demographics, medical history, treatment data and follow up were collected. Fiducials geometries were obtained with Velocity contouring software and MATLAB. Chi-Square, t-test, and Mann-Whitney-U tests were completed using MedCalc.Results73 patients with 77 treatments were identified. Chi-Square analysis revealed chronic obstructive pulmonary disease (COPD) was associated with having Three or more fiducials tracked (p=0.034). Tumors in lower lobes were associated with higher rates of uncertainty errors (p=0.015). The number of fiducials tracked had no impact on local tumor control or overall survival with a median of 36 month follow up. 28 treatments had fiducial centroid data available for geometric analysis. The most common tracking errors were rigid body error (RBE) (57%) and spacing errors (36.4%). Spacing errors had a shorter average minimum inter-fiducial distance versus non-spacing errors (1.0 cm vs 1.7 cm, respectively, p = 0.017). RBE treatments had a longer average maximum distance versus non-RBE treatments (4.0 cm vs 3.0 cm, p = 0.022).ConclusionGreater motion in lower lobes can contribute to certain tracking errors that prevent more fiducials from being tracked. Maintaining inter-fiducial distance between experimentally determined guidelines may limit spacing errors and RBE's, the two most common tracking errors. Increased number of patients in a data set may result in stronger correlations between patient and tumor factors and outcomes." @default.
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- W4378575991 date "2023-11-01" @default.
- W4378575991 modified "2023-09-27" @default.
- W4378575991 title "Clinical Factors That Affect Fiducial Tracking in Robotic SABR for Lung Tumors" @default.
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- W4378575991 doi "https://doi.org/10.1016/j.adro.2023.101274" @default.
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