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• W4378594321 abstract "Genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA methylomic studies offer unprecedented resolution for detecting and profiling cell subsets based on methylomic features. However, existing single-cell methylomic technologies are all based on use of tubes or well plates and these platforms are not easily scalable for handling a large number of single cells. Here we demonstrate a droplet-based microfluidic technology, Drop-BS, to construct single-cell bisulfite sequencing libraries for DNA methylome profiling. Drop-BS takes advantage of the ultrahigh throughput offered by droplet microfluidics to prepare bisulfite sequencing libraries of up to 10,000 single cells within 2 d. We applied the technology to profile mixed cell lines, mouse and human brain tissues to reveal cell type heterogeneity. Drop-BS will pave the way for single-cell methylomic studies requiring examination of a large cell population." @default.
• W4378594321 created "2023-05-29" @default.
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• W4378594321 date "2023-05-28" @default.
• W4378594321 modified "2023-09-28" @default.
• W4378594321 title "Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes" @default.
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• W4378594321 doi "https://doi.org/10.1101/2023.05.26.542421" @default.
• W4378594321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37293095" @default.
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