Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378602456> ?p ?o ?g. }
- W4378602456 abstract "ABSTRACT Insects are ectotherms, and as such, rely on a diverse repertoire of thermoreceptors to monitor environmental temperature and control behavioral thermoregulation. Here, we use structural, phylogenetic, genetic, and functional analyses to show that TRPA5 genes, widespread across numerous insect orders, encode a novel class of noxious heat receptors. We show that in the triatomine bug Rhodnius prolixus , the primary vector of Chagas disease, Rp-TRPA5 2 differs biophysically and structurally from noxious thermoTRPAs previously described in insects. This includes key changes in the ankyrin repeat domain and the selectivity filter of the channel. In vitro , we find evidence that the homo-tetrameric channel is not activated by voltage, but displays high thermosensitivity with an enthalpy change (ΔH) of 72 kcal/mol associated with the channel activation, with a Q 10 = 25 and T° half = 58.6°C. Structural analyses reveal parallels in the overall ion channel architecture between fruit fly TRPA1 and Rp-TRPA5 2 ; however, functional properties and expression patterns indicate that the role of Rp-TRPA5 2 is more similar to that of Pyrexia noxious heat receptors found in fruit flies. Pyrexia genes have been lost in true bugs, and our findings suggest that the rapidly evolving insect TRPA gene family has given rise to an independent evolutionary origin of a molecular transducer that is responsive to noxious thermal stimuli." @default.
- W4378602456 created "2023-05-29" @default.
- W4378602456 creator A5004878954 @default.
- W4378602456 creator A5011300129 @default.
- W4378602456 creator A5042989026 @default.
- W4378602456 creator A5058229517 @default.
- W4378602456 creator A5061270845 @default.
- W4378602456 creator A5063641005 @default.
- W4378602456 creator A5078999332 @default.
- W4378602456 creator A5088678361 @default.
- W4378602456 creator A5091201835 @default.
- W4378602456 creator A5092039201 @default.
- W4378602456 date "2023-05-28" @default.
- W4378602456 modified "2023-09-25" @default.
- W4378602456 title "Convergent evolution of noxious heat sensing by TRPA5, a novel class of heat sensor in<i>Rhodnius prolixus</i>" @default.
- W4378602456 cites W1495409864 @default.
- W4378602456 cites W1499069859 @default.
- W4378602456 cites W1511198581 @default.
- W4378602456 cites W1861203810 @default.
- W4378602456 cites W1945474795 @default.
- W4378602456 cites W1965985711 @default.
- W4378602456 cites W1966453537 @default.
- W4378602456 cites W1967851154 @default.
- W4378602456 cites W1984533345 @default.
- W4378602456 cites W1989395485 @default.
- W4378602456 cites W1991433684 @default.
- W4378602456 cites W1992381837 @default.
- W4378602456 cites W2003374581 @default.
- W4378602456 cites W2004216064 @default.
- W4378602456 cites W2004780613 @default.
- W4378602456 cites W2009815448 @default.
- W4378602456 cites W2010287478 @default.
- W4378602456 cites W2015334777 @default.
- W4378602456 cites W2016596781 @default.
- W4378602456 cites W2021231316 @default.
- W4378602456 cites W2031952894 @default.
- W4378602456 cites W2033527615 @default.
- W4378602456 cites W2036897871 @default.
- W4378602456 cites W2039884257 @default.
- W4378602456 cites W2040664792 @default.
- W4378602456 cites W2042451060 @default.
- W4378602456 cites W2048110883 @default.
- W4378602456 cites W2065275899 @default.
- W4378602456 cites W2066098715 @default.
- W4378602456 cites W2066880427 @default.
- W4378602456 cites W2083176001 @default.
- W4378602456 cites W2085824957 @default.
- W4378602456 cites W2088017515 @default.
- W4378602456 cites W2088450431 @default.
- W4378602456 cites W2089295696 @default.
- W4378602456 cites W2091701866 @default.
- W4378602456 cites W2093534366 @default.
- W4378602456 cites W2104005232 @default.
- W4378602456 cites W2109293109 @default.
- W4378602456 cites W2111647009 @default.
- W4378602456 cites W2118622904 @default.
- W4378602456 cites W2119332446 @default.
- W4378602456 cites W2120512237 @default.
- W4378602456 cites W2128880918 @default.
- W4378602456 cites W2140115368 @default.
- W4378602456 cites W2144663494 @default.
- W4378602456 cites W2145562748 @default.
- W4378602456 cites W2151503690 @default.
- W4378602456 cites W2151602856 @default.
- W4378602456 cites W2152672184 @default.
- W4378602456 cites W2158714788 @default.
- W4378602456 cites W2160378127 @default.
- W4378602456 cites W2162328888 @default.
- W4378602456 cites W2167015723 @default.
- W4378602456 cites W2173301761 @default.
- W4378602456 cites W2175693398 @default.
- W4378602456 cites W2268486506 @default.
- W4378602456 cites W2284863332 @default.
- W4378602456 cites W2333042078 @default.
- W4378602456 cites W2336400828 @default.
- W4378602456 cites W2497266939 @default.
- W4378602456 cites W2519221513 @default.
- W4378602456 cites W2550367067 @default.
- W4378602456 cites W2555104870 @default.
- W4378602456 cites W2569439306 @default.
- W4378602456 cites W2578613951 @default.
- W4378602456 cites W2583210520 @default.
- W4378602456 cites W2614081736 @default.
- W4378602456 cites W2769068417 @default.
- W4378602456 cites W2791720903 @default.
- W4378602456 cites W2802046692 @default.
- W4378602456 cites W2883715734 @default.
- W4378602456 cites W2898204371 @default.
- W4378602456 cites W2925799398 @default.
- W4378602456 cites W2964849163 @default.
- W4378602456 cites W2980170804 @default.
- W4378602456 cites W2984790178 @default.
- W4378602456 cites W2987719291 @default.
- W4378602456 cites W2988396470 @default.
- W4378602456 cites W3002581432 @default.
- W4378602456 cites W3009737049 @default.
- W4378602456 cites W3014072812 @default.
- W4378602456 cites W3041083155 @default.
- W4378602456 cites W3093764162 @default.
- W4378602456 cites W3105778606 @default.