Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378647588> ?p ?o ?g. }
- W4378647588 abstract "Abstract Thioredoxin reductase (TXNRD1) acts as part of a major enforcer of redox homeostasis in the intracellular environment. However, its prognostic value and the relationship between TXNRD1 and core ferroptosis-related genes in hepatocellular carcinoma remain unclear. Here, we systematically analyzed and described the potential function and prognostic value of TXNRD1 in hepatocellular carcinoma. TXNRD1 was aberrantly expressed in several cancer types including liver cancer, and elevated TXNRD1 expression was associated with tumor histological grade and pathologic stage, resulting in markedly shorter survival in these patients. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) results suggested that TXNRD1 is mainly involved in glucose and fat metabolism. Importantly, TXNRD1 may affect cancer prognosis partially by regulating ferroptosis. A prognostic model based on TXNRD1 and seven ferroptosis-related genes (ATG5, PCBP2, SLC7A11, ACSL6, SAT1, SLC40A1, and STEAP3) divided patients with liver cancer into the low-risk group and the high-risk group and was shown to be an independent risk factor for clinical application. We further found that patients with high-risk scores underwent an increased macrophage infiltration compared to patients with low-risk scores, which resulted in immune escape. In short, TXNRD1 is an overlooked predictor, which can be utilized as a candidate prognostic biomarker in liver cancer, and it may hold promise in drug-resistant patients." @default.
- W4378647588 created "2023-05-30" @default.
- W4378647588 creator A5009440660 @default.
- W4378647588 creator A5026146274 @default.
- W4378647588 creator A5058822188 @default.
- W4378647588 creator A5059544054 @default.
- W4378647588 creator A5067390667 @default.
- W4378647588 creator A5069921645 @default.
- W4378647588 creator A5079645451 @default.
- W4378647588 creator A5088528643 @default.
- W4378647588 date "2023-05-29" @default.
- W4378647588 modified "2023-09-27" @default.
- W4378647588 title "Integrating single-cell and bulk RNA sequencing to identify TXNRD1 as effective target for prognostic and therapeutic strategy in Hepatocellular Carcinoma" @default.
- W4378647588 cites W1971155331 @default.
- W4378647588 cites W1980911765 @default.
- W4378647588 cites W1984568177 @default.
- W4378647588 cites W1996311090 @default.
- W4378647588 cites W2017016317 @default.
- W4378647588 cites W2029342214 @default.
- W4378647588 cites W2030443075 @default.
- W4378647588 cites W2096258216 @default.
- W4378647588 cites W2099877688 @default.
- W4378647588 cites W2140525205 @default.
- W4378647588 cites W2344775600 @default.
- W4378647588 cites W2561265564 @default.
- W4378647588 cites W2588530307 @default.
- W4378647588 cites W2616074690 @default.
- W4378647588 cites W2709224048 @default.
- W4378647588 cites W2761031851 @default.
- W4378647588 cites W2809388839 @default.
- W4378647588 cites W2883204623 @default.
- W4378647588 cites W2886984390 @default.
- W4378647588 cites W2889646458 @default.
- W4378647588 cites W2905580912 @default.
- W4378647588 cites W2909817598 @default.
- W4378647588 cites W2919004555 @default.
- W4378647588 cites W2943793201 @default.
- W4378647588 cites W2944417415 @default.
- W4378647588 cites W2945901473 @default.
- W4378647588 cites W2946704044 @default.
- W4378647588 cites W2953831294 @default.
- W4378647588 cites W2975105312 @default.
- W4378647588 cites W2982638381 @default.
- W4378647588 cites W3008311686 @default.
- W4378647588 cites W3009077651 @default.
- W4378647588 cites W3035851500 @default.
- W4378647588 cites W3039649812 @default.
- W4378647588 cites W3108493784 @default.
- W4378647588 cites W3109926818 @default.
- W4378647588 cites W3112871281 @default.
- W4378647588 cites W3122102409 @default.
- W4378647588 cites W3123922203 @default.
- W4378647588 cites W3130270219 @default.
- W4378647588 cites W3132989959 @default.
- W4378647588 cites W3194205162 @default.
- W4378647588 cites W3196211867 @default.
- W4378647588 cites W3214510644 @default.
- W4378647588 cites W4223908131 @default.
- W4378647588 doi "https://doi.org/10.21203/rs.3.rs-2965547/v1" @default.
- W4378647588 hasPublicationYear "2023" @default.
- W4378647588 type Work @default.
- W4378647588 citedByCount "0" @default.
- W4378647588 crossrefType "posted-content" @default.
- W4378647588 hasAuthorship W4378647588A5009440660 @default.
- W4378647588 hasAuthorship W4378647588A5026146274 @default.
- W4378647588 hasAuthorship W4378647588A5058822188 @default.
- W4378647588 hasAuthorship W4378647588A5059544054 @default.
- W4378647588 hasAuthorship W4378647588A5067390667 @default.
- W4378647588 hasAuthorship W4378647588A5069921645 @default.
- W4378647588 hasAuthorship W4378647588A5079645451 @default.
- W4378647588 hasAuthorship W4378647588A5088528643 @default.
- W4378647588 hasBestOaLocation W43786475881 @default.
- W4378647588 hasConcept C121608353 @default.
- W4378647588 hasConcept C126322002 @default.
- W4378647588 hasConcept C143998085 @default.
- W4378647588 hasConcept C2776231280 @default.
- W4378647588 hasConcept C2778019345 @default.
- W4378647588 hasConcept C502942594 @default.
- W4378647588 hasConcept C71924100 @default.
- W4378647588 hasConcept C86803240 @default.
- W4378647588 hasConceptScore W4378647588C121608353 @default.
- W4378647588 hasConceptScore W4378647588C126322002 @default.
- W4378647588 hasConceptScore W4378647588C143998085 @default.
- W4378647588 hasConceptScore W4378647588C2776231280 @default.
- W4378647588 hasConceptScore W4378647588C2778019345 @default.
- W4378647588 hasConceptScore W4378647588C502942594 @default.
- W4378647588 hasConceptScore W4378647588C71924100 @default.
- W4378647588 hasConceptScore W4378647588C86803240 @default.
- W4378647588 hasLocation W43786475881 @default.
- W4378647588 hasOpenAccess W4378647588 @default.
- W4378647588 hasPrimaryLocation W43786475881 @default.
- W4378647588 hasRelatedWork W1999673890 @default.
- W4378647588 hasRelatedWork W2020483997 @default.
- W4378647588 hasRelatedWork W2556053653 @default.
- W4378647588 hasRelatedWork W2766588635 @default.
- W4378647588 hasRelatedWork W3086240832 @default.
- W4378647588 hasRelatedWork W3211646335 @default.
- W4378647588 hasRelatedWork W4239256621 @default.
- W4378647588 hasRelatedWork W4240236077 @default.
- W4378647588 hasRelatedWork W4251581028 @default.