Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378648431> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4378648431 abstract "Pompe disease results in cardiorespiratory distress secondary to glycogen accumulation in the lysosomes of all muscle types and motor neurons. The only approved treatment is enzyme replacement therapy (ERT), which improves survival, however, it cannot completely correct skeletal muscle or motor neuron pathology, therefore respiratory failure persists. To prevent respiratory distress effectively in Pompe patients, there is a need to develop novel approaches that can improve respiratory muscle and motor neuron function. Acute intermittent hypoxia (AIH) is a non-invasive therapy capable of improving respiratory motor function and has has been successful in studies of spinal cord injury and ALS. The hypothesis of this study is that AIH will promote plasticity in skeletal muscle and motor neurons to improve respiration in Pompe mice.2-month-old Pompe and wildtype (WT) mice were exposed to 10 cycles of alternating room air (21% O2) and hypoxia (10% O2) for 5 minutes each, once per day for 7 consecutive days. After the initial week of exposures, mice were given a reminder dose twice per week. An additional group of Pompe and WT mice were only exposed to room air to serve as untreated controls. Mice underwent whole body plethysmography (WBP) immediately before and after the initial week of AIH exposure and again at 6 months of age. During WBP, unanesthetized mice were placed in a Plexiglas chamber and exposed to room air (21% O2) for 2 hours, during which a 5-minute baseline period of quiet breathing was recorded, then the mice were exposed to 3, 10-minute respiratory challenges, first hypoxic air (10% O2), then hypercapnic air (7% CO2), and finally hypoxic and hypercapnic air together. At 6 months of age, respiration (frequency, tidal volume, minute ventilation, and peak inspiratory flow) was slightly improved in Pompe mice receiving AIH during the hypercapnia and hypercapnia + hypoxia challenges compared to untreated Pompe mice. The next steps of this study include evaluating glycogen accumulation and subsequent pathology in the carotid bodies, characterizing proteins associated with hypoxia induced plasticity in the medulla and spinal cord, and analyzing the health and integrity of diaphragm neuromuscular junctions. Our conclusion is that AIH improved respiration under hypercapnia conditions in Pompe mice. NIH/NHLBI K99HL161420 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process." @default.
- W4378648431 created "2023-05-30" @default.
- W4378648431 creator A5002505667 @default.
- W4378648431 creator A5009532288 @default.
- W4378648431 creator A5029407696 @default.
- W4378648431 creator A5040884561 @default.
- W4378648431 creator A5062219284 @default.
- W4378648431 creator A5090485528 @default.
- W4378648431 date "2023-05-01" @default.
- W4378648431 modified "2023-09-27" @default.
- W4378648431 title "Pompe mice have improved respiration during hypercapnic challenge following acute intermittent hypoxia" @default.
- W4378648431 doi "https://doi.org/10.1152/physiol.2023.38.s1.5730201" @default.
- W4378648431 hasPublicationYear "2023" @default.
- W4378648431 type Work @default.
- W4378648431 citedByCount "0" @default.
- W4378648431 crossrefType "journal-article" @default.
- W4378648431 hasAuthorship W4378648431A5002505667 @default.
- W4378648431 hasAuthorship W4378648431A5009532288 @default.
- W4378648431 hasAuthorship W4378648431A5029407696 @default.
- W4378648431 hasAuthorship W4378648431A5040884561 @default.
- W4378648431 hasAuthorship W4378648431A5062219284 @default.
- W4378648431 hasAuthorship W4378648431A5090485528 @default.
- W4378648431 hasConcept C105702510 @default.
- W4378648431 hasConcept C117437137 @default.
- W4378648431 hasConcept C126322002 @default.
- W4378648431 hasConcept C127413603 @default.
- W4378648431 hasConcept C141983124 @default.
- W4378648431 hasConcept C164705383 @default.
- W4378648431 hasConcept C178790620 @default.
- W4378648431 hasConcept C182215343 @default.
- W4378648431 hasConcept C185592680 @default.
- W4378648431 hasConcept C200457457 @default.
- W4378648431 hasConcept C2776006263 @default.
- W4378648431 hasConcept C2776888751 @default.
- W4378648431 hasConcept C2779134260 @default.
- W4378648431 hasConcept C2780596555 @default.
- W4378648431 hasConcept C2780796939 @default.
- W4378648431 hasConcept C42219234 @default.
- W4378648431 hasConcept C42407357 @default.
- W4378648431 hasConcept C534529494 @default.
- W4378648431 hasConcept C540031477 @default.
- W4378648431 hasConcept C71924100 @default.
- W4378648431 hasConcept C7836513 @default.
- W4378648431 hasConcept C78519656 @default.
- W4378648431 hasConceptScore W4378648431C105702510 @default.
- W4378648431 hasConceptScore W4378648431C117437137 @default.
- W4378648431 hasConceptScore W4378648431C126322002 @default.
- W4378648431 hasConceptScore W4378648431C127413603 @default.
- W4378648431 hasConceptScore W4378648431C141983124 @default.
- W4378648431 hasConceptScore W4378648431C164705383 @default.
- W4378648431 hasConceptScore W4378648431C178790620 @default.
- W4378648431 hasConceptScore W4378648431C182215343 @default.
- W4378648431 hasConceptScore W4378648431C185592680 @default.
- W4378648431 hasConceptScore W4378648431C200457457 @default.
- W4378648431 hasConceptScore W4378648431C2776006263 @default.
- W4378648431 hasConceptScore W4378648431C2776888751 @default.
- W4378648431 hasConceptScore W4378648431C2779134260 @default.
- W4378648431 hasConceptScore W4378648431C2780596555 @default.
- W4378648431 hasConceptScore W4378648431C2780796939 @default.
- W4378648431 hasConceptScore W4378648431C42219234 @default.
- W4378648431 hasConceptScore W4378648431C42407357 @default.
- W4378648431 hasConceptScore W4378648431C534529494 @default.
- W4378648431 hasConceptScore W4378648431C540031477 @default.
- W4378648431 hasConceptScore W4378648431C71924100 @default.
- W4378648431 hasConceptScore W4378648431C7836513 @default.
- W4378648431 hasConceptScore W4378648431C78519656 @default.
- W4378648431 hasIssue "S1" @default.
- W4378648431 hasLocation W43786484311 @default.
- W4378648431 hasOpenAccess W4378648431 @default.
- W4378648431 hasPrimaryLocation W43786484311 @default.
- W4378648431 hasRelatedWork W106173884 @default.
- W4378648431 hasRelatedWork W1586366939 @default.
- W4378648431 hasRelatedWork W2031075989 @default.
- W4378648431 hasRelatedWork W2061087295 @default.
- W4378648431 hasRelatedWork W2401276564 @default.
- W4378648431 hasRelatedWork W2404979006 @default.
- W4378648431 hasRelatedWork W2411138595 @default.
- W4378648431 hasRelatedWork W2416442375 @default.
- W4378648431 hasRelatedWork W2992334090 @default.
- W4378648431 hasRelatedWork W4238878620 @default.
- W4378648431 hasVolume "38" @default.
- W4378648431 isParatext "false" @default.
- W4378648431 isRetracted "false" @default.
- W4378648431 workType "article" @default.