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- W4378650470 abstract "Sarcopenia is the progressive loss of muscle mass, strength, and functions as we age. The pathogenesis of sarcopenia is underlined by oxidative stress and inflammation. As such, it is reasonable to suggest that a natural compound with both antioxidant and anti-inflammatory activities could prevent sarcopenia. Curcumin, a natural compound derived from turmeric with both properties, could benefit muscle health. This review aims to summarise the therapeutic effects of curcumin on cellular, animal, and human studies. The available evidence found in the literature showed that curcumin prevents muscle degeneration by upregulating the expression of genes related to protein synthesis and suppressing genes related to muscle degradation. It also protects muscle health by maintaining satellite cell number and function, protecting the mitochondrial function of muscle cells, and suppressing inflammation and oxidative stress. However, it is noted that most studies are preclinical. Evidence from randomised control trials in humans is lacking. In conclusion, curcumin has the potential to be utilised to manage muscle wasting and injury, pending more evidence from carefully planned human clinical trials." @default.
- W4378650470 created "2023-05-30" @default.
- W4378650470 creator A5004770379 @default.
- W4378650470 creator A5037804135 @default.
- W4378650470 creator A5048264570 @default.
- W4378650470 creator A5060850742 @default.
- W4378650470 creator A5081800153 @default.
- W4378650470 date "2023-05-29" @default.
- W4378650470 modified "2023-10-01" @default.
- W4378650470 title "Curcumin as a Therapeutic Agent for Sarcopenia" @default.
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