Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378673832> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4378673832 endingPage "A263" @default.
- W4378673832 startingPage "A263" @default.
- W4378673832 abstract "Abstract Introduction Narcolepsy type 1 (NT1) is associated with frequent sleep stage transitions during nocturnal sleep. In this study, we report the pattern of sleep stage transitions that occurs and its relationship to CSF-orexin levels among pediatric NT1 patients. Furthermore, we study the patterns of sleep stage transitions in patients with Narcolepsy Type 2 (NT2) and Idiopathic Hypersomnia (IH). Methods We conducted a retrospective, cross-sectional study of nocturnal polysomnograms (PSGs) of a cohort of patients ages 5-21 years with NT1 (n=160), NT2 (n=24), IH (n=28), and subjectively sleepy controls (n=115) collected at Boston Children’s Hospital, Boston, MA and University of Bologna, Bologna, Italy. We compared the patterns of transitions between different sleep/wake stages during the nocturnal PSG by diagnostic group as well as by CSF-orexin level (low ≤110 pg/ml; normal >110 pg/ml) using chi-square testing that was adjusted for multiple comparisons. Results NT1 demonstrated a pattern of transitions from wake and all sleep stages except N3 sleep vs. controls, NT2, and IH with frequent transitions between wake and N1 sleep and less frequent transitions from N1 sleep to N2 sleep. The NT2 group had a distinct pattern of transitions from N1 vs. controls with more frequent transitions to REM sleep and less frequent transitions to N2. The IH group showed a similar pattern of sleep/wake transitions vs. controls. The pattern of transitions for the low CSF orexin group was different for all sleep stages and wake vs. normal level with frequent transitions from N2 sleep and REM sleep to wake and N1 sleep. Conclusion Young NT1 patients have a unique pattern of transitions between sleep/wake states. These findings are further confirmed by CSF orexin level. NT2 patients have a pattern of sleep stage transitions more similar to controls with the exception of the transitions from N1 sleep suggesting dysregulation of this light sleep stage. In contrast, the IH group shows patterns of transitions between sleep stages and wake that are similar to controls. Overall, results support differing sleep phenotypes demarcating these patients with severe daytime sleepiness. Support (if any) National Institutes of Health grant 5K23NS104267-2 to K.M" @default.
- W4378673832 created "2023-05-30" @default.
- W4378673832 creator A5021236074 @default.
- W4378673832 creator A5025236648 @default.
- W4378673832 creator A5030287146 @default.
- W4378673832 creator A5049498267 @default.
- W4378673832 creator A5057157134 @default.
- W4378673832 creator A5063246513 @default.
- W4378673832 creator A5083801943 @default.
- W4378673832 date "2023-05-01" @default.
- W4378673832 modified "2023-10-02" @default.
- W4378673832 title "0599 Sleep Stage Transition Patterns Among Youth with CNS Disorders of Hypersomnolence" @default.
- W4378673832 doi "https://doi.org/10.1093/sleep/zsad077.0599" @default.
- W4378673832 hasPublicationYear "2023" @default.
- W4378673832 type Work @default.
- W4378673832 citedByCount "0" @default.
- W4378673832 crossrefType "journal-article" @default.
- W4378673832 hasAuthorship W4378673832A5021236074 @default.
- W4378673832 hasAuthorship W4378673832A5025236648 @default.
- W4378673832 hasAuthorship W4378673832A5030287146 @default.
- W4378673832 hasAuthorship W4378673832A5049498267 @default.
- W4378673832 hasAuthorship W4378673832A5057157134 @default.
- W4378673832 hasAuthorship W4378673832A5063246513 @default.
- W4378673832 hasAuthorship W4378673832A5083801943 @default.
- W4378673832 hasBestOaLocation W43786738321 @default.
- W4378673832 hasConcept C110539466 @default.
- W4378673832 hasConcept C111919701 @default.
- W4378673832 hasConcept C118303440 @default.
- W4378673832 hasConcept C118552586 @default.
- W4378673832 hasConcept C126322002 @default.
- W4378673832 hasConcept C15744967 @default.
- W4378673832 hasConcept C16568411 @default.
- W4378673832 hasConcept C170493617 @default.
- W4378673832 hasConcept C187212893 @default.
- W4378673832 hasConcept C2775841894 @default.
- W4378673832 hasConcept C2777334680 @default.
- W4378673832 hasConcept C2778205975 @default.
- W4378673832 hasConcept C2779494582 @default.
- W4378673832 hasConcept C2779680196 @default.
- W4378673832 hasConcept C2781326671 @default.
- W4378673832 hasConcept C2910364982 @default.
- W4378673832 hasConcept C41008148 @default.
- W4378673832 hasConcept C522805319 @default.
- W4378673832 hasConcept C71924100 @default.
- W4378673832 hasConcept C72563966 @default.
- W4378673832 hasConceptScore W4378673832C110539466 @default.
- W4378673832 hasConceptScore W4378673832C111919701 @default.
- W4378673832 hasConceptScore W4378673832C118303440 @default.
- W4378673832 hasConceptScore W4378673832C118552586 @default.
- W4378673832 hasConceptScore W4378673832C126322002 @default.
- W4378673832 hasConceptScore W4378673832C15744967 @default.
- W4378673832 hasConceptScore W4378673832C16568411 @default.
- W4378673832 hasConceptScore W4378673832C170493617 @default.
- W4378673832 hasConceptScore W4378673832C187212893 @default.
- W4378673832 hasConceptScore W4378673832C2775841894 @default.
- W4378673832 hasConceptScore W4378673832C2777334680 @default.
- W4378673832 hasConceptScore W4378673832C2778205975 @default.
- W4378673832 hasConceptScore W4378673832C2779494582 @default.
- W4378673832 hasConceptScore W4378673832C2779680196 @default.
- W4378673832 hasConceptScore W4378673832C2781326671 @default.
- W4378673832 hasConceptScore W4378673832C2910364982 @default.
- W4378673832 hasConceptScore W4378673832C41008148 @default.
- W4378673832 hasConceptScore W4378673832C522805319 @default.
- W4378673832 hasConceptScore W4378673832C71924100 @default.
- W4378673832 hasConceptScore W4378673832C72563966 @default.
- W4378673832 hasIssue "Supplement_1" @default.
- W4378673832 hasLocation W43786738321 @default.
- W4378673832 hasOpenAccess W4378673832 @default.
- W4378673832 hasPrimaryLocation W43786738321 @default.
- W4378673832 hasRelatedWork W126971091 @default.
- W4378673832 hasRelatedWork W1972468654 @default.
- W4378673832 hasRelatedWork W2001651446 @default.
- W4378673832 hasRelatedWork W2030421130 @default.
- W4378673832 hasRelatedWork W2141186476 @default.
- W4378673832 hasRelatedWork W2390892226 @default.
- W4378673832 hasRelatedWork W2408765218 @default.
- W4378673832 hasRelatedWork W2513100112 @default.
- W4378673832 hasRelatedWork W326560207 @default.
- W4378673832 hasRelatedWork W4205377703 @default.
- W4378673832 hasVolume "46" @default.
- W4378673832 isParatext "false" @default.
- W4378673832 isRetracted "false" @default.
- W4378673832 workType "article" @default.