Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378674265> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4378674265 abstract "Ibuprofen is one of the most commonly used compounds in the treatment of pain, fever, and inflammation. Despite its beneficial effects, the long-term use of ibuprofen has been previously associated with increased risks for cardiovascular diseases and all-cause mortality. Relatively little is known about the signaling pathways or mechanism(s) involved in ibuprofen’s ability to increase the risk of cardiovascular diseases. Very little is also known about sex-related differences with respect to ibuprofen. We investigated the effects of ibuprofen (100 mg/kg/day, equivalent to about a 500mg tablet/day for humans) on mouse hearts using proteomics. Proteomic results suggest that female mice hearts exposed to ibuprofen for 7 days had tenfold more changes than male mice hearts exposed to ibuprofen for 7 days. Both the expression and activity of β5i immunoproteasome was significantly increased in female mice heart relative to ibuprofen-treated male heart mice. Ibuprofen treatment altered mitochondrial function in both male and female mice. Ibuprofen also induced ROS generation and decreased mitochondrial membrane potential in both male and female mice. However, ibuprofen attenuated mitochondrial complex I activity only in female hearts. Several other signaling pathways were also altered only in female mouse hearts. This study found major ibuprofen-mediated selective effects on male and female mice hearts, with specific sex differences in mitochondrial and proteasome function in mice hearts. NIEHS/Superfund P42 ES004699 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process." @default.
- W4378674265 created "2023-05-30" @default.
- W4378674265 creator A5038455444 @default.
- W4378674265 creator A5049533111 @default.
- W4378674265 creator A5060237156 @default.
- W4378674265 creator A5072698091 @default.
- W4378674265 date "2023-05-01" @default.
- W4378674265 modified "2023-09-27" @default.
- W4378674265 title "Ibuprofen causes mitochondrial and proteasome dysfunction in murine hearts" @default.
- W4378674265 doi "https://doi.org/10.1152/physiol.2023.38.s1.5735230" @default.
- W4378674265 hasPublicationYear "2023" @default.
- W4378674265 type Work @default.
- W4378674265 citedByCount "0" @default.
- W4378674265 crossrefType "journal-article" @default.
- W4378674265 hasAuthorship W4378674265A5038455444 @default.
- W4378674265 hasAuthorship W4378674265A5049533111 @default.
- W4378674265 hasAuthorship W4378674265A5060237156 @default.
- W4378674265 hasAuthorship W4378674265A5072698091 @default.
- W4378674265 hasConcept C126322002 @default.
- W4378674265 hasConcept C134018914 @default.
- W4378674265 hasConcept C2779944601 @default.
- W4378674265 hasConcept C28859421 @default.
- W4378674265 hasConcept C71924100 @default.
- W4378674265 hasConcept C86803240 @default.
- W4378674265 hasConcept C95444343 @default.
- W4378674265 hasConcept C98274493 @default.
- W4378674265 hasConceptScore W4378674265C126322002 @default.
- W4378674265 hasConceptScore W4378674265C134018914 @default.
- W4378674265 hasConceptScore W4378674265C2779944601 @default.
- W4378674265 hasConceptScore W4378674265C28859421 @default.
- W4378674265 hasConceptScore W4378674265C71924100 @default.
- W4378674265 hasConceptScore W4378674265C86803240 @default.
- W4378674265 hasConceptScore W4378674265C95444343 @default.
- W4378674265 hasConceptScore W4378674265C98274493 @default.
- W4378674265 hasIssue "S1" @default.
- W4378674265 hasLocation W43786742651 @default.
- W4378674265 hasOpenAccess W4378674265 @default.
- W4378674265 hasPrimaryLocation W43786742651 @default.
- W4378674265 hasRelatedWork W1966504330 @default.
- W4378674265 hasRelatedWork W1974041167 @default.
- W4378674265 hasRelatedWork W1979139803 @default.
- W4378674265 hasRelatedWork W2001431596 @default.
- W4378674265 hasRelatedWork W2030889776 @default.
- W4378674265 hasRelatedWork W2037631372 @default.
- W4378674265 hasRelatedWork W2040058909 @default.
- W4378674265 hasRelatedWork W2132898409 @default.
- W4378674265 hasRelatedWork W2589691381 @default.
- W4378674265 hasRelatedWork W2748952813 @default.
- W4378674265 hasVolume "38" @default.
- W4378674265 isParatext "false" @default.
- W4378674265 isRetracted "false" @default.
- W4378674265 workType "article" @default.