Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378675061> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4378675061 abstract "The Schlager inbred hypertensive (BPH/2J) mouse strain was developed by Gunther Schlager more than 45 years ago and have been recognized as a model of neurogenic hypertension. Activation of the sympathetic nervous system contributes to the maintainance of high blood pressure levels in BPH/2J male mice with the systolic blood pressure (SBP) starting to increase at seven weeks of age until reaching the highest value at 20 weeks of age. Several studies have shown cardiovascular dysfunction in these hypertensive mice, but no one has demonstrated whether heart and vascular dysfunction are present prior to the elevation in SBP. Our objective was to determine if cardiovascular dysfunction in male BPH/2J mice happens prior to the elevation of blood pressure. We hypothesized that cardiovascular remodeling along wih vascular dysfunction in mesenteric resistance arteries (MRA) occurs prior to the hypertension in BPH/2J mice, supporting the notion that the mechanism of hypertension in BPH/2J mice is not predominantly neurogenic. We evaluated intact-endothelium MRA function from 6-weeks-old male BPH/2J and normotensive control mice (BPN/3J). Intact-endothelium MRA were mounted on wire myographs. SBP was measured directly in the left carotid artery, and cardiac function and morphology was evaluated by echocardiography. Second harmonic generation was used to evaluate collagen deposition in MRA, and hematoxin and eosin staining done for cardiomyocyte hypertrophy. These data were analyzed using the Student t test ( p<0.05). SBP was not different between 6-weeks-old male BPH/2J and BPN/3J mice (78±2.33mmHg vs. 89±1.20 mmHg; n=3-4, respectively, p>0.05). BPH/2J presented increased left ventricle anterior wall thickness during systole (1.79±0.1mm) and diastole (1.13±0.06mm, n=4) compared to BPN/3J (systole: 1.46±0.08mm; diastole: 0.93±0.05mm, n=5, p<0.05). In addition, cardiomyocyte area values was higher in BPH/2J (1,188±51μm2, n=8) than BPN/3J (820±53μm2, n=4, p<0.05), suggesting that cardiac hypertrophy occurs prior to the onset of hypertension. BPH/2J mice presented increased phenylphrine-induced contraction (Rmax: BPH/2J: 6.25±0.54 vs. BPN/3J: 4.23±0.28 mN, n=4, p<0.05) and decreased endothelium-dependent relaxation (Rmax: BPH/2J: 76±5, n=4 vs. BPN/3J: 93±2%, n=3, p<0.05), and BPH/2J MRA presented a tendency to increase arterial collagen content compared to BPN/3J mice. These data reveal that cardiac remodeling and vascular dysfunction and fibrosis occurs prior to the elevation of SBP in BPH/2J mice, suggesting novel contributive causes of hypertension in Schlager mice. R00GM118885, R01HL149762, R00HL151889, and NHLBI (R00HL151889) This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process." @default.
- W4378675061 created "2023-05-30" @default.
- W4378675061 creator A5007044090 @default.
- W4378675061 creator A5022191748 @default.
- W4378675061 creator A5028006240 @default.
- W4378675061 creator A5030845503 @default.
- W4378675061 creator A5037211359 @default.
- W4378675061 creator A5043665968 @default.
- W4378675061 creator A5045675141 @default.
- W4378675061 creator A5056536469 @default.
- W4378675061 date "2023-05-01" @default.
- W4378675061 modified "2023-09-27" @default.
- W4378675061 title "Cardiac Hypertrophy and Vascular Dysfunction in Resistance Arteries Occurs Prior to the Onset of Hypertension in Schlager (BPH/2J) Mice" @default.
- W4378675061 doi "https://doi.org/10.1152/physiol.2023.38.s1.5731596" @default.
- W4378675061 hasPublicationYear "2023" @default.
- W4378675061 type Work @default.
- W4378675061 citedByCount "0" @default.
- W4378675061 crossrefType "journal-article" @default.
- W4378675061 hasAuthorship W4378675061A5007044090 @default.
- W4378675061 hasAuthorship W4378675061A5022191748 @default.
- W4378675061 hasAuthorship W4378675061A5028006240 @default.
- W4378675061 hasAuthorship W4378675061A5030845503 @default.
- W4378675061 hasAuthorship W4378675061A5037211359 @default.
- W4378675061 hasAuthorship W4378675061A5043665968 @default.
- W4378675061 hasAuthorship W4378675061A5045675141 @default.
- W4378675061 hasAuthorship W4378675061A5056536469 @default.
- W4378675061 hasConcept C125473707 @default.
- W4378675061 hasConcept C126322002 @default.
- W4378675061 hasConcept C134018914 @default.
- W4378675061 hasConcept C164705383 @default.
- W4378675061 hasConcept C167414201 @default.
- W4378675061 hasConcept C204232928 @default.
- W4378675061 hasConcept C2776002628 @default.
- W4378675061 hasConcept C2776533406 @default.
- W4378675061 hasConcept C2778086073 @default.
- W4378675061 hasConcept C2780972559 @default.
- W4378675061 hasConcept C3018791406 @default.
- W4378675061 hasConcept C58245268 @default.
- W4378675061 hasConcept C71924100 @default.
- W4378675061 hasConcept C84393581 @default.
- W4378675061 hasConceptScore W4378675061C125473707 @default.
- W4378675061 hasConceptScore W4378675061C126322002 @default.
- W4378675061 hasConceptScore W4378675061C134018914 @default.
- W4378675061 hasConceptScore W4378675061C164705383 @default.
- W4378675061 hasConceptScore W4378675061C167414201 @default.
- W4378675061 hasConceptScore W4378675061C204232928 @default.
- W4378675061 hasConceptScore W4378675061C2776002628 @default.
- W4378675061 hasConceptScore W4378675061C2776533406 @default.
- W4378675061 hasConceptScore W4378675061C2778086073 @default.
- W4378675061 hasConceptScore W4378675061C2780972559 @default.
- W4378675061 hasConceptScore W4378675061C3018791406 @default.
- W4378675061 hasConceptScore W4378675061C58245268 @default.
- W4378675061 hasConceptScore W4378675061C71924100 @default.
- W4378675061 hasConceptScore W4378675061C84393581 @default.
- W4378675061 hasIssue "S1" @default.
- W4378675061 hasLocation W43786750611 @default.
- W4378675061 hasOpenAccess W4378675061 @default.
- W4378675061 hasPrimaryLocation W43786750611 @default.
- W4378675061 hasRelatedWork W1514902666 @default.
- W4378675061 hasRelatedWork W2084399385 @default.
- W4378675061 hasRelatedWork W2095147394 @default.
- W4378675061 hasRelatedWork W2141037139 @default.
- W4378675061 hasRelatedWork W2149169995 @default.
- W4378675061 hasRelatedWork W2171089442 @default.
- W4378675061 hasRelatedWork W2252618402 @default.
- W4378675061 hasRelatedWork W2377341836 @default.
- W4378675061 hasRelatedWork W2391947682 @default.
- W4378675061 hasRelatedWork W2416811611 @default.
- W4378675061 hasVolume "38" @default.
- W4378675061 isParatext "false" @default.
- W4378675061 isRetracted "false" @default.
- W4378675061 workType "article" @default.