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• W4378679085 abstract "Recent research has identified genes capable of causing early-onset forms of glaucoma as well as hundreds of genetic variants associated with polygenic complex forms of disease, including primary open-angle glaucoma (POAG). Genes known to cause early-onset disease can be used for genetic testing which can provide a molecular diagnosis that informs genetic counseling and risk assessment as well as identifies individuals who could be candidates for gene-based therapies as they emerge. In addition, polygenic risk scores (PRSs) based on genome-wide association studies and risk variants have been developed for POAG and have shown that patients with the highest genetic burden also have earlier disease onset, higher IOP, thinner nerve fiber layer thickness, and greater need for incisional surgery. Future studies using PRS approaches could also identify subgroups of POAG patients who may benefit from novel therapies targeting specific biological pathways and processes." @default.
• W4378679085 created "2023-05-30" @default.
• W4378679085 creator A5086641481 @default.
• W4378679085 date "2023-01-01" @default.
• W4378679085 modified "2023-09-27" @default.
• W4378679085 title "Genetic testing and gene therapy in glaucoma" @default.
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• W4378679085 doi "https://doi.org/10.1016/b978-0-323-88442-6.00002-9" @default.
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