Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378696509> ?p ?o ?g. }
- W4378696509 endingPage "186" @default.
- W4378696509 startingPage "161" @default.
- W4378696509 abstract "Alzheimer’s disease (AD) is the most common type of neurodegenerative disease and is primarily characterized by progressive cognitive dysfunction and behavioral impairment. It accounts for approximately 50–75% of senile dementia cases. Mild cognitive impairment (MCI) is an intermediate state of cognition, somewhere between normal aging and dementia, and has a high risk of conversion to AD or other types of dementia, with approximately 10–15% of MCI cases converting to AD each year. With the steady increase in life expectancy, the incidence of AD has grown each year, and the number of patients with AD worldwide is projected to reach 130 million by 2050, which will place an immense burden on social development and home care. However, the pathogenesis of AD remains poorly understood, and currently, there is no effective pharmaceutical treatment. Therefore, AD continues to be a key focus of and challenge to research in the field of global medicine. The characteristic pathological changes observed in AD involve senile plaques that are formed by the extracellular deposition of β-amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) that are formed of hyperphosphorylated tau protein, and extensive neuronal loss. The primary imaging techniques currently utilized in AD research include MRI and PET. Structural MRI can show the atrophy of the medial temporal lobe (MTL), which is now considered to be a diagnostic marker of AD, while functional MRI (fMRI) is a valuable tool for exploring the functional changes of the brain and the neurobiological mechanisms of AD. PET, however, is an important imaging technique for the detection of AD-specific brain metabolism and the in vivo assessment of pathological proteins. In this chapter, we will summarize the advances in research regarding the application of fMRI, PET, and PET/MR in the study of AD." @default.
- W4378696509 created "2023-05-30" @default.
- W4378696509 creator A5066163403 @default.
- W4378696509 creator A5072191207 @default.
- W4378696509 creator A5077388232 @default.
- W4378696509 creator A5086738268 @default.
- W4378696509 date "2023-01-01" @default.
- W4378696509 modified "2023-09-27" @default.
- W4378696509 title "Research Applications of Positron Emission Tomography/Magnetic Resonance (PET/MR) Imaging in Alzheimer’s Disease (AD)" @default.
- W4378696509 cites W1018991385 @default.
- W4378696509 cites W1918775028 @default.
- W4378696509 cites W1972776675 @default.
- W4378696509 cites W1994839798 @default.
- W4378696509 cites W2007572953 @default.
- W4378696509 cites W2011502145 @default.
- W4378696509 cites W2025320437 @default.
- W4378696509 cites W2030309279 @default.
- W4378696509 cites W2040178194 @default.
- W4378696509 cites W2048755200 @default.
- W4378696509 cites W2054294333 @default.
- W4378696509 cites W2055186021 @default.
- W4378696509 cites W2084787525 @default.
- W4378696509 cites W2090523774 @default.
- W4378696509 cites W2098440617 @default.
- W4378696509 cites W2101334128 @default.
- W4378696509 cites W2103105772 @default.
- W4378696509 cites W2145214784 @default.
- W4378696509 cites W2147370235 @default.
- W4378696509 cites W2151384687 @default.
- W4378696509 cites W2167160506 @default.
- W4378696509 cites W2315419474 @default.
- W4378696509 cites W2473213421 @default.
- W4378696509 cites W2509497121 @default.
- W4378696509 cites W2781583747 @default.
- W4378696509 cites W2792545364 @default.
- W4378696509 cites W2798054687 @default.
- W4378696509 cites W2801875717 @default.
- W4378696509 cites W2804443444 @default.
- W4378696509 cites W2897709375 @default.
- W4378696509 cites W2907306160 @default.
- W4378696509 cites W2912390532 @default.
- W4378696509 cites W2912746915 @default.
- W4378696509 cites W2927152915 @default.
- W4378696509 cites W2942719601 @default.
- W4378696509 cites W2963918385 @default.
- W4378696509 cites W3011237672 @default.
- W4378696509 cites W3082294768 @default.
- W4378696509 cites W4234788469 @default.
- W4378696509 doi "https://doi.org/10.1007/978-981-19-9902-4_8" @default.
- W4378696509 hasPublicationYear "2023" @default.
- W4378696509 type Work @default.
- W4378696509 citedByCount "0" @default.
- W4378696509 crossrefType "book-chapter" @default.
- W4378696509 hasAuthorship W4378696509A5066163403 @default.
- W4378696509 hasAuthorship W4378696509A5072191207 @default.
- W4378696509 hasAuthorship W4378696509A5077388232 @default.
- W4378696509 hasAuthorship W4378696509A5086738268 @default.
- W4378696509 hasConcept C126838900 @default.
- W4378696509 hasConcept C142724271 @default.
- W4378696509 hasConcept C143409427 @default.
- W4378696509 hasConcept C15744967 @default.
- W4378696509 hasConcept C169760540 @default.
- W4378696509 hasConcept C169900460 @default.
- W4378696509 hasConcept C2775842073 @default.
- W4378696509 hasConcept C2779134260 @default.
- W4378696509 hasConcept C2779483572 @default.
- W4378696509 hasConcept C502032728 @default.
- W4378696509 hasConcept C58693492 @default.
- W4378696509 hasConcept C68026918 @default.
- W4378696509 hasConcept C71924100 @default.
- W4378696509 hasConceptScore W4378696509C126838900 @default.
- W4378696509 hasConceptScore W4378696509C142724271 @default.
- W4378696509 hasConceptScore W4378696509C143409427 @default.
- W4378696509 hasConceptScore W4378696509C15744967 @default.
- W4378696509 hasConceptScore W4378696509C169760540 @default.
- W4378696509 hasConceptScore W4378696509C169900460 @default.
- W4378696509 hasConceptScore W4378696509C2775842073 @default.
- W4378696509 hasConceptScore W4378696509C2779134260 @default.
- W4378696509 hasConceptScore W4378696509C2779483572 @default.
- W4378696509 hasConceptScore W4378696509C502032728 @default.
- W4378696509 hasConceptScore W4378696509C58693492 @default.
- W4378696509 hasConceptScore W4378696509C68026918 @default.
- W4378696509 hasConceptScore W4378696509C71924100 @default.
- W4378696509 hasLocation W43786965091 @default.
- W4378696509 hasOpenAccess W4378696509 @default.
- W4378696509 hasPrimaryLocation W43786965091 @default.
- W4378696509 hasRelatedWork W1250647964 @default.
- W4378696509 hasRelatedWork W1996795769 @default.
- W4378696509 hasRelatedWork W2036086601 @default.
- W4378696509 hasRelatedWork W2053861465 @default.
- W4378696509 hasRelatedWork W2062489139 @default.
- W4378696509 hasRelatedWork W2083316737 @default.
- W4378696509 hasRelatedWork W2096570098 @default.
- W4378696509 hasRelatedWork W2159291176 @default.
- W4378696509 hasRelatedWork W2540391766 @default.
- W4378696509 hasRelatedWork W4211011739 @default.
- W4378696509 isParatext "false" @default.
- W4378696509 isRetracted "false" @default.