FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378715095> ?p ?o ?g. }

• W4378715095 endingPage "1505" @default.
• W4378715095 startingPage "1495" @default.
• W4378715095 abstract "Background: Triple negative breast cancer cells (TNBC) are a small part of cancer-inducing cells in breast cancer, which are characterized by high metastatic and self-renewal. Self-renewal has the ability to renew itself and loses control of proliferation. Curcuma longa extract (CL) and Phyllanthus niruri extract (PN) known to have anti-proliferative effects on cancer cells. However, the effects of combination CL and PN on TNBC proliferation still unclear. Aims: This study aimed to evaluate the antiproliferative effects of the combination CL and PN on TNBC MDAMB-231 and attempted to elucidate the underlying molecular mechanisms. Subjects and Methods: The dried rhizomes of Curcuma longa and the herbs of Phyllanthus niruri were macerated with ethanol for 72 h.The antiproliferative and synergistic effects of combination CL and PN were investigated using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Combination index values were calculated using CompuSyn (ComboSyn, Inc, Paramus, NJ). The cell cycle and apoptosis assay were determined by propidium iodide (PI) and PI-AnnexinV assay under flow cytometer, respectively. The intracellular ROS levels were evaluated using 2′,7′-Dichlorodihydrofluorescein diacetate (DCFDA) assay. The mRNA expressions of proliferation-related genes in the cells were determined using bioinformatic assay. Results: The CL and PN single treatment caused a potent and dose-dependent decrease in the percentage of viable cells with IC50 value of 13 μg/mL and 45 μg/mL for 24 h, respectively. The combination index values of the different combinations ranged from 0.08 – 0.90, indicating slightly strong to very strong synergistic effects. The combination of CL and PN also remarkably induced the S- and G2/M-phases cell cycle arrest that leading to apoptosis induction. Furthermore, the combination of CL and PN treatment induced the intracellular reactive oxygen species (ROS) levels. Mechanistically, the AKT1, EP300, STAT3 and EGFR signaling as potential targets of combination CL and PN in antiproliferation and antimetastatic of TNBC. Conclusions: The combination of CL and PN exerted promising antiproliferative effects in TNBC. Therefore, CL and PN may be considered a potential source for the development of potent anticancer drugs for breast cancer treatment." @default.
• W4378715095 created "2023-05-30" @default.
• W4378715095 creator A5009266823 @default.
• W4378715095 creator A5030507465 @default.
• W4378715095 creator A5072908123 @default.
• W4378715095 creator A5063688517 @default.
• W4378715095 date "2023-05-01" @default.
• W4378715095 modified "2023-09-30" @default.
• W4378715095 title "Combination Curcuma longa and Phyllanthus niruri Extract Potentiate Antiproliferative in Triple Negative Breast Cancer MDAMB-231 Cells" @default.
• W4378715095 cites W1505531771 @default.
• W4378715095 cites W1855644362 @default.
• W4378715095 cites W1975232450 @default.
• W4378715095 cites W1982397837 @default.
• W4378715095 cites W2011247930 @default.
• W4378715095 cites W2039082329 @default.
• W4378715095 cites W2054318449 @default.
• W4378715095 cites W2054464764 @default.
• W4378715095 cites W2059831422 @default.
• W4378715095 cites W2061710186 @default.
• W4378715095 cites W2095506424 @default.
• W4378715095 cites W2099805317 @default.
• W4378715095 cites W2107142392 @default.
• W4378715095 cites W2129187010 @default.
• W4378715095 cites W2144491599 @default.
• W4378715095 cites W2147069592 @default.
• W4378715095 cites W2318272432 @default.
• W4378715095 cites W2402636472 @default.
• W4378715095 cites W2513437066 @default.
• W4378715095 cites W2526631627 @default.
• W4378715095 cites W2580879916 @default.
• W4378715095 cites W2615601352 @default.
• W4378715095 cites W2742399016 @default.
• W4378715095 cites W2763410913 @default.
• W4378715095 cites W2797287370 @default.
• W4378715095 cites W2802030122 @default.
• W4378715095 cites W2916045508 @default.
• W4378715095 cites W2921722535 @default.
• W4378715095 cites W2946899637 @default.
• W4378715095 cites W2958290248 @default.
• W4378715095 cites W2960622715 @default.
• W4378715095 cites W2966860817 @default.
• W4378715095 cites W2967873149 @default.
• W4378715095 cites W2979334582 @default.
• W4378715095 cites W2991728669 @default.
• W4378715095 cites W3003322622 @default.
• W4378715095 cites W3010774829 @default.
• W4378715095 cites W3023737077 @default.
• W4378715095 cites W3100783618 @default.
• W4378715095 cites W3136113031 @default.
• W4378715095 cites W3137992975 @default.
• W4378715095 cites W3154293384 @default.
• W4378715095 cites W3159931666 @default.
• W4378715095 cites W3180375767 @default.
• W4378715095 cites W3190429855 @default.
• W4378715095 cites W3194262110 @default.
• W4378715095 cites W4210379686 @default.
• W4378715095 cites W4214924946 @default.
• W4378715095 cites W4223592813 @default.
• W4378715095 cites W4282931791 @default.
• W4378715095 cites W4290101582 @default.
• W4378715095 cites W4320709368 @default.
• W4378715095 doi "https://doi.org/10.31557/apjcp.2023.24.5.1495" @default.
• W4378715095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37247268" @default.
• W4378715095 hasPublicationYear "2023" @default.
• W4378715095 type Work @default.
• W4378715095 citedByCount "0" @default.
• W4378715095 crossrefType "journal-article" @default.
• W4378715095 hasAuthorship W4378715095A5009266823 @default.
• W4378715095 hasAuthorship W4378715095A5030507465 @default.
• W4378715095 hasAuthorship W4378715095A5063688517 @default.
• W4378715095 hasAuthorship W4378715095A5072908123 @default.
• W4378715095 hasBestOaLocation W43787150951 @default.
• W4378715095 hasConcept C121608353 @default.
• W4378715095 hasConcept C153911025 @default.
• W4378715095 hasConcept C185592680 @default.
• W4378715095 hasConcept C190283241 @default.
• W4378715095 hasConcept C2775934118 @default.
• W4378715095 hasConcept C2776718122 @default.
• W4378715095 hasConcept C2777230291 @default.
• W4378715095 hasConcept C2780110267 @default.
• W4378715095 hasConcept C2780783641 @default.
• W4378715095 hasConcept C31573885 @default.
• W4378715095 hasConcept C530470458 @default.
• W4378715095 hasConcept C54355233 @default.
• W4378715095 hasConcept C55493867 @default.
• W4378715095 hasConcept C556039675 @default.
• W4378715095 hasConcept C62112901 @default.
• W4378715095 hasConcept C71924100 @default.
• W4378715095 hasConcept C86803240 @default.
• W4378715095 hasConcept C96232424 @default.
• W4378715095 hasConcept C98274493 @default.
• W4378715095 hasConceptScore W4378715095C121608353 @default.
• W4378715095 hasConceptScore W4378715095C153911025 @default.
• W4378715095 hasConceptScore W4378715095C185592680 @default.
• W4378715095 hasConceptScore W4378715095C190283241 @default.
• W4378715095 hasConceptScore W4378715095C2775934118 @default.
• W4378715095 hasConceptScore W4378715095C2776718122 @default.
• W4378715095 hasConceptScore W4378715095C2777230291 @default.

• next