Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378715596> ?p ?o ?g. }
- W4378715596 endingPage "983" @default.
- W4378715596 startingPage "968" @default.
- W4378715596 abstract "Abstract CD4 + T cells and CD4 + chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4 + T cells promote tumor regression are incompletely understood. With the help of functional intravital imaging, we report that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19 CD4 + CAR T cells. Mechanistically, mouse or human CD4 + CAR T-cell-derived IFN-γ diffused extensively to act on tumor cells at distance selectively killing tumors sensitive to cytokine-induced apoptosis, including antigen-negative variants. In anti-CD19 CAR T-cell-treated patients exhibiting elevated CAR CD4:CD8 ratios, strong induction of serum IFN-γ was associated with increased survival. We propose that the sensitivity of tumor cells to the pro-apoptotic activity of IFN-γ is a major determinant of CD4 + CAR T-cell efficacy and may be considered to guide the use of CD4 + T cells during immunotherapy." @default.
- W4378715596 created "2023-05-30" @default.
- W4378715596 creator A5002673895 @default.
- W4378715596 creator A5004581254 @default.
- W4378715596 creator A5031971429 @default.
- W4378715596 creator A5032277321 @default.
- W4378715596 creator A5033073385 @default.
- W4378715596 creator A5039812479 @default.
- W4378715596 creator A5045171283 @default.
- W4378715596 creator A5059879003 @default.
- W4378715596 creator A5061098159 @default.
- W4378715596 creator A5066960287 @default.
- W4378715596 creator A5074855451 @default.
- W4378715596 creator A5080788742 @default.
- W4378715596 creator A5082525618 @default.
- W4378715596 creator A5090273284 @default.
- W4378715596 creator A5090496106 @default.
- W4378715596 date "2023-05-29" @default.
- W4378715596 modified "2023-10-17" @default.
- W4378715596 title "Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity" @default.
- W4378715596 cites W1544477391 @default.
- W4378715596 cites W1624950583 @default.
- W4378715596 cites W1627799814 @default.
- W4378715596 cites W1937801816 @default.
- W4378715596 cites W1963522404 @default.
- W4378715596 cites W1965222920 @default.
- W4378715596 cites W1969003615 @default.
- W4378715596 cites W1970786645 @default.
- W4378715596 cites W1980621729 @default.
- W4378715596 cites W2017010917 @default.
- W4378715596 cites W2021472146 @default.
- W4378715596 cites W2022667374 @default.
- W4378715596 cites W2029661710 @default.
- W4378715596 cites W2030317951 @default.
- W4378715596 cites W2037681980 @default.
- W4378715596 cites W2039213819 @default.
- W4378715596 cites W2046562334 @default.
- W4378715596 cites W2049790267 @default.
- W4378715596 cites W2053967595 @default.
- W4378715596 cites W2059427680 @default.
- W4378715596 cites W2063497807 @default.
- W4378715596 cites W2080641261 @default.
- W4378715596 cites W2107456821 @default.
- W4378715596 cites W2118796952 @default.
- W4378715596 cites W2119147717 @default.
- W4378715596 cites W2123972913 @default.
- W4378715596 cites W2138397823 @default.
- W4378715596 cites W2148360952 @default.
- W4378715596 cites W2167017590 @default.
- W4378715596 cites W2168910938 @default.
- W4378715596 cites W2169876627 @default.
- W4378715596 cites W2219506342 @default.
- W4378715596 cites W2313482121 @default.
- W4378715596 cites W2465860350 @default.
- W4378715596 cites W2522313999 @default.
- W4378715596 cites W2598700764 @default.
- W4378715596 cites W2609998953 @default.
- W4378715596 cites W2742763599 @default.
- W4378715596 cites W2751674330 @default.
- W4378715596 cites W2768550677 @default.
- W4378715596 cites W2771398071 @default.
- W4378715596 cites W2773804840 @default.
- W4378715596 cites W2790935413 @default.
- W4378715596 cites W2803369586 @default.
- W4378715596 cites W2807930859 @default.
- W4378715596 cites W2864786814 @default.
- W4378715596 cites W2884754721 @default.
- W4378715596 cites W2914484956 @default.
- W4378715596 cites W2914505559 @default.
- W4378715596 cites W2932352133 @default.
- W4378715596 cites W2933526900 @default.
- W4378715596 cites W2971302797 @default.
- W4378715596 cites W2975666914 @default.
- W4378715596 cites W2999450347 @default.
- W4378715596 cites W3003583769 @default.
- W4378715596 cites W3006233208 @default.
- W4378715596 cites W3009119115 @default.
- W4378715596 cites W3009409341 @default.
- W4378715596 cites W3026009801 @default.
- W4378715596 cites W3032578076 @default.
- W4378715596 cites W3035502195 @default.
- W4378715596 cites W3039277443 @default.
- W4378715596 cites W3045074094 @default.
- W4378715596 cites W3084862157 @default.
- W4378715596 cites W3088071546 @default.
- W4378715596 cites W3129999347 @default.
- W4378715596 cites W3130718611 @default.
- W4378715596 cites W3137476328 @default.
- W4378715596 cites W3202804227 @default.
- W4378715596 cites W3205770628 @default.
- W4378715596 cites W4224115060 @default.
- W4378715596 cites W4229005336 @default.
- W4378715596 cites W4285719527 @default.
- W4378715596 cites W4288065939 @default.
- W4378715596 cites W4312815231 @default.
- W4378715596 doi "https://doi.org/10.1038/s43018-023-00570-7" @default.
- W4378715596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37248395" @default.
- W4378715596 hasPublicationYear "2023" @default.