Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378717563> ?p ?o ?g. }
- W4378717563 abstract "Abstract Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity in the olfactory epithelium than in CSF or skin. To get an insight into α-synuclein (α-syn) distribution within the nervous system and reasons for low sensitivity, we compared SAA assessment of nasal brushings and skin biopsies in PD ( n = 27) and iRBD patients ( n = 18) and unaffected controls ( n = 30). α-syn misfolding was overall found less commonly in the olfactory epithelium than in the skin, which could be partially explained by the nasal brushing matrix exerting an inhibitory effect on aggregation. Importantly, the α-syn distribution was not uniform: there was a higher deposition of misfolded α-syn across all sampled tissues in the iRBD cohort compared to PD (supporting the notion of RBD as a marker of a more malignant subtype of synucleinopathy) and in a subgroup of PD patients, misfolded α-syn was detectable only in the olfactory epithelium, suggestive of the recently proposed brain-first PD subtype. Assaying α-syn of diverse origins, such as olfactory (part of the central nervous system) and skin (peripheral nervous system), could increase diagnostic accuracy and allow better stratification of patients." @default.
- W4378717563 created "2023-05-30" @default.
- W4378717563 creator A5009208394 @default.
- W4378717563 creator A5013217424 @default.
- W4378717563 creator A5014270872 @default.
- W4378717563 creator A5025268449 @default.
- W4378717563 creator A5029994251 @default.
- W4378717563 creator A5034219333 @default.
- W4378717563 creator A5038318352 @default.
- W4378717563 creator A5047502254 @default.
- W4378717563 creator A5049457142 @default.
- W4378717563 creator A5061992185 @default.
- W4378717563 creator A5062376240 @default.
- W4378717563 creator A5063331457 @default.
- W4378717563 creator A5065881904 @default.
- W4378717563 creator A5070186968 @default.
- W4378717563 creator A5080176487 @default.
- W4378717563 creator A5080852796 @default.
- W4378717563 creator A5081943452 @default.
- W4378717563 creator A5082906602 @default.
- W4378717563 creator A5083574042 @default.
- W4378717563 date "2023-05-29" @default.
- W4378717563 modified "2023-10-15" @default.
- W4378717563 title "Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies" @default.
- W4378717563 cites W1508476525 @default.
- W4378717563 cites W1871264924 @default.
- W4378717563 cites W1925709673 @default.
- W4378717563 cites W1963771535 @default.
- W4378717563 cites W1973852637 @default.
- W4378717563 cites W1974433124 @default.
- W4378717563 cites W1997941486 @default.
- W4378717563 cites W2003438491 @default.
- W4378717563 cites W2022252153 @default.
- W4378717563 cites W2024566803 @default.
- W4378717563 cites W2039449904 @default.
- W4378717563 cites W2042150946 @default.
- W4378717563 cites W2048444499 @default.
- W4378717563 cites W2064284597 @default.
- W4378717563 cites W2073449985 @default.
- W4378717563 cites W2074682163 @default.
- W4378717563 cites W2084347944 @default.
- W4378717563 cites W2086999805 @default.
- W4378717563 cites W2087484885 @default.
- W4378717563 cites W2087866471 @default.
- W4378717563 cites W2094438822 @default.
- W4378717563 cites W2103866720 @default.
- W4378717563 cites W2111372299 @default.
- W4378717563 cites W2112455323 @default.
- W4378717563 cites W2133093462 @default.
- W4378717563 cites W2140296969 @default.
- W4378717563 cites W2149752970 @default.
- W4378717563 cites W2168946626 @default.
- W4378717563 cites W2171753818 @default.
- W4378717563 cites W2213230363 @default.
- W4378717563 cites W2517512733 @default.
- W4378717563 cites W2562322582 @default.
- W4378717563 cites W2589875191 @default.
- W4378717563 cites W2604697479 @default.
- W4378717563 cites W2809410660 @default.
- W4378717563 cites W2886698364 @default.
- W4378717563 cites W2965069106 @default.
- W4378717563 cites W2966520883 @default.
- W4378717563 cites W2968583737 @default.
- W4378717563 cites W2973042700 @default.
- W4378717563 cites W2974380083 @default.
- W4378717563 cites W3005252823 @default.
- W4378717563 cites W3011465354 @default.
- W4378717563 cites W3088907309 @default.
- W4378717563 cites W3112487866 @default.
- W4378717563 cites W3134318550 @default.
- W4378717563 cites W3153424147 @default.
- W4378717563 cites W3156241108 @default.
- W4378717563 cites W3212048545 @default.
- W4378717563 cites W3214409719 @default.
- W4378717563 cites W4200138153 @default.
- W4378717563 cites W4210816442 @default.
- W4378717563 cites W4225159648 @default.
- W4378717563 cites W4254687493 @default.
- W4378717563 cites W4280549370 @default.
- W4378717563 cites W4281559139 @default.
- W4378717563 cites W4286716392 @default.
- W4378717563 cites W4288084637 @default.
- W4378717563 cites W4310384354 @default.
- W4378717563 cites W4317242213 @default.
- W4378717563 doi "https://doi.org/10.1038/s41531-023-00519-8" @default.
- W4378717563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37248217" @default.
- W4378717563 hasPublicationYear "2023" @default.
- W4378717563 type Work @default.
- W4378717563 citedByCount "3" @default.
- W4378717563 countsByYear W43787175632023 @default.
- W4378717563 crossrefType "journal-article" @default.
- W4378717563 hasAuthorship W4378717563A5009208394 @default.
- W4378717563 hasAuthorship W4378717563A5013217424 @default.
- W4378717563 hasAuthorship W4378717563A5014270872 @default.
- W4378717563 hasAuthorship W4378717563A5025268449 @default.
- W4378717563 hasAuthorship W4378717563A5029994251 @default.
- W4378717563 hasAuthorship W4378717563A5034219333 @default.
- W4378717563 hasAuthorship W4378717563A5038318352 @default.
- W4378717563 hasAuthorship W4378717563A5047502254 @default.
- W4378717563 hasAuthorship W4378717563A5049457142 @default.