Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378717878> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4378717878 abstract "The nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathway is involved in the regulation of cellular responses to oxidative stress. Nrf2 acts as a cell protector from inflammation, cellular damage, and tumorigenesis, whereas Keap1 is a negative regulator of Nrf2. Dysregulation of the Nrf2/Keap1 pathway results in tumorigenesis and the active metabolism of tumor cells, leading to high resistance to radiotherapy. This study aimed to evaluate the predictive role of Nrf2 and Keap1 in the radiosensitivity and prognosis of locally advanced rectal cancer (LARC).In total, 90 patients with LARC underwent surgery after preoperative chemoradiotherapy (CRT). Endoscopic biopsies from the tumors were obtained before radiation, and the Nrf2 and Keap1 expressions were assessed by immunohistochemistry. The response to therapy was evaluated after surgery following CRT according to the pathologic tumor regression grade. The disease-free survival (DFS) and overall survival rates were also documented. The association between the Nrf2 and Keap1 immunoreactivity and the clinicopathological parameters was analyzed.The overexpression of the nuclear Nrf2 before CRT showed a significant correlation with better DFS. The cytoplasmic Nrf2 expression was associated with more residual tumors after radiotherapy and a more unfavorable DFS, indicating lower radiosensitivity.CRT is an important issue in LARC and is a major aspect of treatment. Thus, the Nrf2/Keap1 expression may be a potential predictor of preoperative therapeutic resistance. The Nrf2-Keap1 modulators that interact with each other may also be effectively applicable to CRT effect in LARC." @default.
- W4378717878 created "2023-05-30" @default.
- W4378717878 creator A5015727351 @default.
- W4378717878 creator A5040102576 @default.
- W4378717878 creator A5042010119 @default.
- W4378717878 creator A5075118952 @default.
- W4378717878 creator A5076031843 @default.
- W4378717878 creator A5083483613 @default.
- W4378717878 date "2023-01-01" @default.
- W4378717878 modified "2023-10-17" @default.
- W4378717878 title "Nuclear Factor Erythroid 2-Related Factor 2/Kelch-like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis" @default.
- W4378717878 cites W1992724001 @default.
- W4378717878 cites W2112825838 @default.
- W4378717878 cites W2114194406 @default.
- W4378717878 cites W2115338196 @default.
- W4378717878 cites W2154632188 @default.
- W4378717878 cites W2401030213 @default.
- W4378717878 cites W2521343068 @default.
- W4378717878 cites W2611475096 @default.
- W4378717878 cites W2781298385 @default.
- W4378717878 cites W2911636470 @default.
- W4378717878 cites W2917192301 @default.
- W4378717878 cites W2976453023 @default.
- W4378717878 cites W2986456455 @default.
- W4378717878 cites W3025521622 @default.
- W4378717878 cites W3103333555 @default.
- W4378717878 cites W3120754043 @default.
- W4378717878 cites W3128893442 @default.
- W4378717878 cites W3198779519 @default.
- W4378717878 cites W4312563640 @default.
- W4378717878 cites W952491933 @default.
- W4378717878 doi "https://doi.org/10.3346/jkms.2023.38.e200" @default.
- W4378717878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37401495" @default.
- W4378717878 hasPublicationYear "2023" @default.
- W4378717878 type Work @default.
- W4378717878 citedByCount "0" @default.
- W4378717878 crossrefType "journal-article" @default.
- W4378717878 hasAuthorship W4378717878A5015727351 @default.
- W4378717878 hasAuthorship W4378717878A5040102576 @default.
- W4378717878 hasAuthorship W4378717878A5042010119 @default.
- W4378717878 hasAuthorship W4378717878A5075118952 @default.
- W4378717878 hasAuthorship W4378717878A5076031843 @default.
- W4378717878 hasAuthorship W4378717878A5083483613 @default.
- W4378717878 hasBestOaLocation W43787178781 @default.
- W4378717878 hasConcept C104317684 @default.
- W4378717878 hasConcept C121608353 @default.
- W4378717878 hasConcept C126322002 @default.
- W4378717878 hasConcept C142724271 @default.
- W4378717878 hasConcept C143998085 @default.
- W4378717878 hasConcept C204232928 @default.
- W4378717878 hasConcept C206684579 @default.
- W4378717878 hasConcept C2776529522 @default.
- W4378717878 hasConcept C2778424827 @default.
- W4378717878 hasConcept C502942594 @default.
- W4378717878 hasConcept C509974204 @default.
- W4378717878 hasConcept C526805850 @default.
- W4378717878 hasConcept C55493867 @default.
- W4378717878 hasConcept C555283112 @default.
- W4378717878 hasConcept C71924100 @default.
- W4378717878 hasConcept C86339819 @default.
- W4378717878 hasConcept C86803240 @default.
- W4378717878 hasConceptScore W4378717878C104317684 @default.
- W4378717878 hasConceptScore W4378717878C121608353 @default.
- W4378717878 hasConceptScore W4378717878C126322002 @default.
- W4378717878 hasConceptScore W4378717878C142724271 @default.
- W4378717878 hasConceptScore W4378717878C143998085 @default.
- W4378717878 hasConceptScore W4378717878C204232928 @default.
- W4378717878 hasConceptScore W4378717878C206684579 @default.
- W4378717878 hasConceptScore W4378717878C2776529522 @default.
- W4378717878 hasConceptScore W4378717878C2778424827 @default.
- W4378717878 hasConceptScore W4378717878C502942594 @default.
- W4378717878 hasConceptScore W4378717878C509974204 @default.
- W4378717878 hasConceptScore W4378717878C526805850 @default.
- W4378717878 hasConceptScore W4378717878C55493867 @default.
- W4378717878 hasConceptScore W4378717878C555283112 @default.
- W4378717878 hasConceptScore W4378717878C71924100 @default.
- W4378717878 hasConceptScore W4378717878C86339819 @default.
- W4378717878 hasConceptScore W4378717878C86803240 @default.
- W4378717878 hasFunder F4320322120 @default.
- W4378717878 hasIssue "26" @default.
- W4378717878 hasLocation W43787178781 @default.
- W4378717878 hasLocation W43787178782 @default.
- W4378717878 hasOpenAccess W4378717878 @default.
- W4378717878 hasPrimaryLocation W43787178781 @default.
- W4378717878 hasRelatedWork W1934485925 @default.
- W4378717878 hasRelatedWork W2062380899 @default.
- W4378717878 hasRelatedWork W2068669225 @default.
- W4378717878 hasRelatedWork W2073792004 @default.
- W4378717878 hasRelatedWork W2363923610 @default.
- W4378717878 hasRelatedWork W2386230446 @default.
- W4378717878 hasRelatedWork W2579945087 @default.
- W4378717878 hasRelatedWork W2769390123 @default.
- W4378717878 hasRelatedWork W3029180858 @default.
- W4378717878 hasRelatedWork W2892891728 @default.
- W4378717878 hasVolume "38" @default.
- W4378717878 isParatext "false" @default.
- W4378717878 isRetracted "false" @default.
- W4378717878 workType "article" @default.