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• W4378741302 abstract "A Japanese woman in her 60s developed a kidney injury 9 weeks after treatment with pemetrexed, carboplatin, and pembrolizumab for stage IV lung adenocarcinoma. A renal biopsy showed chronic tubulointerstitial damage with minimal focal interstitial inflammation, consistent with pemetrexed-induced nephropathy; thus, pemetrexed was withdrawn. However, the kidney injury continued to worsen. A repeated biopsy showed severe acute tubulointerstitial nephritis, suggestive of a pembrolizumab-induced immune-related adverse event (irAE). The worsening after pemetrexed discontinuation suggested that the irAE had already begun, as the first biopsy showed focal inflammation. This case suggests thatcombining immune checkpoints and chemotherapy requires considering concurrent drug-induced nephrotoxicity." @default.
• W4378741302 created "2023-05-31" @default.
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• W4378741302 date "2023-01-01" @default.
• W4378741302 modified "2023-09-26" @default.
• W4378741302 title "Renal Immune-related Adverse Event of Pembrolizumab Masked by Pemetrexed: A Case Report" @default.
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• W4378741302 doi "https://doi.org/10.2169/internalmedicine.1640-23" @default.
• W4378741302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37258166" @default.
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