FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378744908> ?p ?o ?g. }

• W4378744908 abstract "Two-photon imaging of genetically-encoded calcium indicators (GECIs) has traditionally relied on intracranial injections of adeno-associated virus (AAV) or transgenic animals to achieve expression. Intracranial injections require an invasive surgery and result in a relatively small volume of tissue labeling. Transgenic animals, although they can have brain-wide GECI expression, often express GECIs in only a small subset of neurons, may have abnormal behavioral phenotypes, and are currently limited to older generations of GECIs. Inspired by recent developments in the synthesis of AAVs that readily cross the blood brain barrier, we tested whether an alternative strategy of intravenously injecting AAV-PHP.eB is suitable for two-photon calcium imaging of neurons over many months after injection. We injected C57BL/6 J mice with AAV-PHP.eB-Synapsin-jGCaMP7s via the retro-orbital sinus. After allowing 5 to 34 weeks for expression, we performed conventional and widefield two-photon imaging of layers 2/3, 4 and 5 of the primary visual cortex. We found reproducible trial-by-trial neural responses and tuning properties consistent with known feature selectivity in the visual cortex. Thus, intravenous injection of AAV-PHP.eB does not interfere with the normal processing in neural circuits. In vivo and histological images show no nuclear expression of jGCaMP7s for at least 34 weeks post-injection." @default.
• W4378744908 created "2023-05-31" @default.
• W4378744908 creator A5020054629 @default.
• W4378744908 creator A5081424274 @default.
• W4378744908 date "2023-05-12" @default.
• W4378744908 modified "2023-09-28" @default.
• W4378744908 title "High fidelity sensory-evoked responses in neocortex after intravenous injection of genetically encoded calcium sensors" @default.
• W4378744908 cites W1571164133 @default.
• W4378744908 cites W1581119831 @default.
• W4378744908 cites W1921600937 @default.
• W4378744908 cites W1929487673 @default.
• W4378744908 cites W1964314167 @default.
• W4378744908 cites W1967626349 @default.
• W4378744908 cites W1985450720 @default.
• W4378744908 cites W1997375364 @default.
• W4378744908 cites W2013070880 @default.
• W4378744908 cites W2015155463 @default.
• W4378744908 cites W2016406290 @default.
• W4378744908 cites W2028616747 @default.
• W4378744908 cites W2041457988 @default.
• W4378744908 cites W2046031057 @default.
• W4378744908 cites W2051760280 @default.
• W4378744908 cites W2062619493 @default.
• W4378744908 cites W2074942478 @default.
• W4378744908 cites W2081805772 @default.
• W4378744908 cites W2086723623 @default.
• W4378744908 cites W2086871516 @default.
• W4378744908 cites W2093078836 @default.
• W4378744908 cites W2109234881 @default.
• W4378744908 cites W2117940227 @default.
• W4378744908 cites W2129346251 @default.
• W4378744908 cites W2144868947 @default.
• W4378744908 cites W2155063410 @default.
• W4378744908 cites W2171332611 @default.
• W4378744908 cites W2256579886 @default.
• W4378744908 cites W2274452385 @default.
• W4378744908 cites W2310204605 @default.
• W4378744908 cites W2394641095 @default.
• W4378744908 cites W2569458742 @default.
• W4378744908 cites W2616012590 @default.
• W4378744908 cites W2616960090 @default.
• W4378744908 cites W2708579841 @default.
• W4378744908 cites W2773803332 @default.
• W4378744908 cites W2801454635 @default.
• W4378744908 cites W2802576439 @default.
• W4378744908 cites W2910480910 @default.
• W4378744908 cites W2916541448 @default.
• W4378744908 cites W2937274403 @default.
• W4378744908 cites W2950007293 @default.
• W4378744908 cites W2950401911 @default.
• W4378744908 cites W2950849463 @default.
• W4378744908 cites W2952059832 @default.
• W4378744908 cites W2980791559 @default.
• W4378744908 cites W2986362275 @default.
• W4378744908 cites W2986841475 @default.
• W4378744908 cites W2994874474 @default.
• W4378744908 cites W3000731319 @default.
• W4378744908 cites W3006121449 @default.
• W4378744908 cites W3016724860 @default.
• W4378744908 cites W3089857460 @default.
• W4378744908 cites W3133698431 @default.
• W4378744908 cites W3168390192 @default.
• W4378744908 cites W3197397300 @default.
• W4378744908 cites W3207402145 @default.
• W4378744908 cites W3210894955 @default.
• W4378744908 cites W3213642587 @default.
• W4378744908 cites W4200543263 @default.
• W4378744908 cites W4210845348 @default.
• W4378744908 cites W4224281833 @default.
• W4378744908 cites W4285684864 @default.
• W4378744908 cites W4294251987 @default.
• W4378744908 cites W4319234799 @default.
• W4378744908 doi "https://doi.org/10.3389/fnins.2023.1181828" @default.
• W4378744908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37250396" @default.
• W4378744908 hasPublicationYear "2023" @default.
• W4378744908 type Work @default.
• W4378744908 citedByCount "0" @default.
• W4378744908 crossrefType "journal-article" @default.
• W4378744908 hasAuthorship W4378744908A5020054629 @default.
• W4378744908 hasAuthorship W4378744908A5081424274 @default.
• W4378744908 hasBestOaLocation W43787449081 @default.
• W4378744908 hasConcept C102230213 @default.
• W4378744908 hasConcept C104317684 @default.
• W4378744908 hasConcept C126322002 @default.
• W4378744908 hasConcept C142724271 @default.
• W4378744908 hasConcept C150903083 @default.
• W4378744908 hasConcept C169760540 @default.
• W4378744908 hasConcept C185592680 @default.
• W4378744908 hasConcept C207001950 @default.
• W4378744908 hasConcept C2776032975 @default.
• W4378744908 hasConcept C2777222312 @default.
• W4378744908 hasConcept C2779345533 @default.
• W4378744908 hasConcept C519063684 @default.
• W4378744908 hasConcept C55493867 @default.
• W4378744908 hasConcept C71924100 @default.
• W4378744908 hasConcept C86803240 @default.
• W4378744908 hasConceptScore W4378744908C102230213 @default.
• W4378744908 hasConceptScore W4378744908C104317684 @default.
• W4378744908 hasConceptScore W4378744908C126322002 @default.
• W4378744908 hasConceptScore W4378744908C142724271 @default.

• next