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- W4378746564 abstract "In vaccine clinical trials, vaccine efficacy endpoint analysis is usually associated with in high cost or extended study duration, due to the generally low infection rate. Correlate of protection (CoP), which refers to surrogate endpoint, usually immunological response, that can reliably predict the treatment effect, provides a more efficient and less costly approach to evaluate the vaccine. To handle the challenge of the missingness in the unobserved surrogate immune biomarker, the pseudo-score (PS) method, semiparametric method and pseudo-likelihood (PL) method demonstrated their advantages on different aspects. In this article, we propose new methodologies to combine the advantages of PS and PL with semiparametric methods respectively, to achieve higher estimate efficiency, allow continuous baseline predictor variable, and handle multiple surrogate markers. The advantage of our methodologies are demonstrated by a simulation study in different settings and applied to a case study, which eventually can improve the chance of a successful trial." @default.
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- W4378746564 date "2023-05-29" @default.
- W4378746564 modified "2023-10-14" @default.
- W4378746564 title "Semiparametric pseudo‐score and pseudo‐likelihood for evaluating correlate of protection in vaccine trials" @default.
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- W4378746564 doi "https://doi.org/10.1002/sim.9807" @default.
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