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- W4378746573 abstract "Full-length mRNAs transfer between adjacent mammalian cells via direct cell-to-cell connections called tunneling nanotubes (TNTs). However, the extent of mRNA transfer at the transcriptome-wide level (the 'transferome') is unknown. Here, we analyzed the transferome in an in vitro human-mouse cell co-culture model using RNA-sequencing. We found that mRNA transfer is non-selective, prevalent across the human transcriptome, and that the amount of transfer to mouse embryonic fibroblasts (MEFs) strongly correlates with the endogenous level of gene expression in donor human breast cancer cells. Typically,<1% of endogenous mRNAs undergo transfer. Non-selective, expression-dependent RNA transfer was further validated using synthetic reporters. RNA transfer appears contact-dependent via TNTs, as exemplified for several mRNAs. Notably, significant differential changes in the native MEF transcriptome were observed in response to co-culture, including the upregulation of multiple cancer and cancer-associated fibroblast-related genes and pathways. Together, these results lead us to suggest that TNT-mediated RNA transfer could be a phenomenon of physiological importance under both normal and pathogenic conditions." @default.
- W4378746573 created "2023-05-31" @default.
- W4378746573 creator A5015929193 @default.
- W4378746573 creator A5026160462 @default.
- W4378746573 creator A5034639385 @default.
- W4378746573 creator A5051069055 @default.
- W4378746573 creator A5052259098 @default.
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- W4378746573 creator A5074877560 @default.
- W4378746573 creator A5092049679 @default.
- W4378746573 date "2023-05-30" @default.
- W4378746573 modified "2023-10-17" @default.
- W4378746573 title "Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture" @default.
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