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• W4378746618 abstract "Background: Pain is a common cause of hospitalization in sickle cell disease (SCD) patients. Failure to effectively control pain remains a challenge in patient care. Materials & methods: The authors conducted a cross-sectional study to determine the effect of CYP2D6 and UGT2B7 polymorphisms on pain management in 106 Zimbabwean SCD patients. Participant information was collected on a questionnaire. Genotyping was conducted using the GenoPharm ® pharmacogenomics open array panel containing CYP2D6 and UGT genetic variants implicated in opioid response. Results: The reduced function alleles CYP2D6*17 and *29 had high frequencies of 15.9% and 12.9%, respectively. UGT2B7 rs73823859 showed a statistically significant correlation with pain levels (p = 0.0454). Conclusion: This study demonstrated the role of UGT2B7 polymorphism in SCD patient pain management." @default.
• W4378746618 created "2023-05-31" @default.
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• W4378746618 date "2023-05-01" @default.
• W4378746618 modified "2023-09-25" @default.
• W4378746618 title "Pharmacogenetics of pain management in Zimbabwean patients with sickle cell disease" @default.
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• W4378746618 doi "https://doi.org/10.2217/pgs-2023-0045" @default.
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