Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378746677> ?p ?o ?g. }
- W4378746677 abstract "Ado-trastuzumab emtansine (T-DM1) is an antibody–drug conjugate approved by the FDA in 2013 for advanced HER2-positive breast cancer treatment exhibiting promising clinical benefits. However, HER2 overexpression and gene amplification have also been reported in other cancers like gastric cancer, non-small cell lung cancer (NSCLC), and colorectal cancer . Numerous preclinical studies have also revealed the significant antitumor effect of T-DM1 on HER2-positive tumors. With the advancement in research, several clinical trials have been conducted to investigate the antitumor effect of T-DM1. In this review, we briefly introduced the pharmacological effects of T-DM1. We reviewed its preclinical and clinical studies, especially on other HER2-positive cancers, establishing what has been encountered between its preclinical and clinical studies. In clinical studies, we found that T-DM1 has a therapeutic value on other cancers. An insignificant effect was observed on gastric cancer and NSCLC, inconsistent with the preclinical studies." @default.
- W4378746677 created "2023-05-31" @default.
- W4378746677 creator A5024512077 @default.
- W4378746677 creator A5059749674 @default.
- W4378746677 creator A5062165630 @default.
- W4378746677 creator A5072373907 @default.
- W4378746677 creator A5089147944 @default.
- W4378746677 date "2023-05-11" @default.
- W4378746677 modified "2023-09-28" @default.
- W4378746677 title "Ado-tratuzumab emtansine beyond breast cancer: therapeutic role of targeting other HER2-positive cancers" @default.
- W4378746677 cites W189063294 @default.
- W4378746677 cites W1904060183 @default.
- W4378746677 cites W1959902744 @default.
- W4378746677 cites W1964230131 @default.
- W4378746677 cites W1968590850 @default.
- W4378746677 cites W1971738718 @default.
- W4378746677 cites W1974192138 @default.
- W4378746677 cites W2000028774 @default.
- W4378746677 cites W2005553722 @default.
- W4378746677 cites W2005971097 @default.
- W4378746677 cites W2006621710 @default.
- W4378746677 cites W2011144540 @default.
- W4378746677 cites W2015918488 @default.
- W4378746677 cites W2025697041 @default.
- W4378746677 cites W2035194737 @default.
- W4378746677 cites W2046073869 @default.
- W4378746677 cites W2046476894 @default.
- W4378746677 cites W2048454522 @default.
- W4378746677 cites W2049449785 @default.
- W4378746677 cites W2054841768 @default.
- W4378746677 cites W2058967130 @default.
- W4378746677 cites W2059605875 @default.
- W4378746677 cites W2064839484 @default.
- W4378746677 cites W2065855960 @default.
- W4378746677 cites W2074760070 @default.
- W4378746677 cites W2093215461 @default.
- W4378746677 cites W2096813843 @default.
- W4378746677 cites W2097097666 @default.
- W4378746677 cites W2100183121 @default.
- W4378746677 cites W2116154302 @default.
- W4378746677 cites W2119870604 @default.
- W4378746677 cites W2124913341 @default.
- W4378746677 cites W2132244669 @default.
- W4378746677 cites W2133613600 @default.
- W4378746677 cites W2136197678 @default.
- W4378746677 cites W2137853125 @default.
- W4378746677 cites W2141393790 @default.
- W4378746677 cites W2147609992 @default.
- W4378746677 cites W2151950281 @default.
- W4378746677 cites W2159967578 @default.
- W4378746677 cites W2162488896 @default.
- W4378746677 cites W2163851812 @default.
- W4378746677 cites W2176904228 @default.
- W4378746677 cites W2188563595 @default.
- W4378746677 cites W2277879584 @default.
- W4378746677 cites W2329092217 @default.
- W4378746677 cites W2336815607 @default.
- W4378746677 cites W2528534371 @default.
- W4378746677 cites W2529607059 @default.
- W4378746677 cites W2565778855 @default.
- W4378746677 cites W2567683174 @default.
- W4378746677 cites W2587699801 @default.
- W4378746677 cites W2588881638 @default.
- W4378746677 cites W2598685895 @default.
- W4378746677 cites W2730775742 @default.
- W4378746677 cites W2735084022 @default.
- W4378746677 cites W2735285257 @default.
- W4378746677 cites W2740953687 @default.
- W4378746677 cites W2745824859 @default.
- W4378746677 cites W2767597066 @default.
- W4378746677 cites W2772606138 @default.
- W4378746677 cites W2775672838 @default.
- W4378746677 cites W2784371446 @default.
- W4378746677 cites W2889957730 @default.
- W4378746677 cites W2902218997 @default.
- W4378746677 cites W2909903956 @default.
- W4378746677 cites W2911718257 @default.
- W4378746677 cites W2913433668 @default.
- W4378746677 cites W2923297356 @default.
- W4378746677 cites W2928807055 @default.
- W4378746677 cites W2943671268 @default.
- W4378746677 cites W2943699531 @default.
- W4378746677 cites W2971737201 @default.
- W4378746677 cites W2976742560 @default.
- W4378746677 cites W2977567559 @default.
- W4378746677 cites W2980930466 @default.
- W4378746677 cites W2994610571 @default.
- W4378746677 cites W2997567849 @default.
- W4378746677 cites W3004603728 @default.
- W4378746677 cites W3020356666 @default.
- W4378746677 cites W3022962123 @default.
- W4378746677 cites W3039853672 @default.
- W4378746677 cites W3044100340 @default.
- W4378746677 cites W3088411120 @default.
- W4378746677 cites W3110833960 @default.
- W4378746677 cites W3112421058 @default.
- W4378746677 cites W3119060529 @default.
- W4378746677 cites W3128646645 @default.
- W4378746677 cites W3147820834 @default.
- W4378746677 cites W3150595399 @default.