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- W4378746779 endingPage "640" @default.
- W4378746779 startingPage "631" @default.
- W4378746779 abstract "Recent technological advances have identified distinct subpopulations and roles of the cardiac innate immune cells, specifically macrophages and neutrophils. Studies on distinct metabolic pathways of macrophage and neutrophil in cardiac injury are expanding. Here, we elaborate on the roles of cardiac macrophages and neutrophils in concomitance with their metabolism in normal and diseased hearts.Single-cell techniques combined with fate mapping have identified the clusters of innate immune cell subpopulations present in the resting and diseased hearts. We are beginning to know about the presence of cardiac resident macrophages and their functions. Resident macrophages perform cardiac homeostatic roles, whereas infiltrating neutrophils and macrophages contribute to tissue damage during cardiac injury with eventual role in repair. Prior studies show that metabolic pathways regulate the phenotypes of the macrophages and neutrophils during cardiac injury. Profiling the metabolism of the innate immune cells, especially of resident macrophages during chronic and acute cardiac diseases, can further the understanding of cardiac immunometabolism." @default.
- W4378746779 created "2023-05-31" @default.
- W4378746779 creator A5027798315 @default.
- W4378746779 creator A5029700686 @default.
- W4378746779 creator A5078807320 @default.
- W4378746779 date "2023-05-30" @default.
- W4378746779 modified "2023-10-16" @default.
- W4378746779 title "The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective" @default.
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