FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378746798> ?p ?o ?g. }

• W4378746798 abstract "Background: Severe acute pancreatitis (SAP) is a severe form of acute pancreatitis with the potential to cause life-threatening complications. Patients with acute SAP require surgical intervention and are admitted to the intensive care unit for non-invasive ventilation. Dexmedetomidine (Dex) is currently used by intensive care clinicians and anaesthesiologists as an adjunctive sedative. Therefore, the clinical availability of Dex makes it easier to implement in SAP treatment than developing new drugs. Methods: Randomly dividing thirty rats into sham-operated (Sham), SAP, and Dex groups. The severity of pancreatic tissue injury in each rat was assessed by Hematoxylin and eosin (HE) staining. Serum amylase activity and inflammatory factor levels were measured using commercially available kits. The expressions of necroptosis-related proteins, myeloperoxidase (MPO), CD68, and 4-hydroxy-trans-2-nonenal (HNE) were detected using immunohistochemistry (IHC). Transferase-mediated dUTP nick-end labeling (TUNEL) staining was utilized to identify pancreatic acinar cell apoptosis. The subcellular organelle structure of pancreatic acinar cells was observed using transmission electron microscopy. The regulatory effect of Dex on the gene expression profile of SAP rat pancreas tissue was investigated using RNA sequencing. We screened for differentially expressed genes (DEGs). Quantitative real-time PCR (qRT-PCR) measured critical DEG mRNA expression in rat pancreatic tissues. Results: Dex attenuated SAP-induced pancreatic injury, infiltration of neutrophils and macrophages, and oxidative stress. Dex inhibited the expression of necroptosis-associated proteins RIPK1, RIPK3, and MLKL and alleviated apoptosis in acinar cells. Dex also mitigated the structural damage caused by SAP to mitochondria and endoplasmic reticulum. Dex inhibited SAP-induced 473 DEGs, as determined by RNA sequencing. Dex may regulate SAP-induced inflammatory response and tissue damage by inhibiting the toll-like receptor/nuclear factor κB (TLR/NF-κB) signaling pathway and neutrophil extracellular trap formation. Conclusion: This study elucidated the remarkable effect of Dex against SAP and investigated the potential mechanism of action, providing an experimental base for the future clinical application of Dex in the treatment of SAP." @default.
• W4378746798 created "2023-05-31" @default.
• W4378746798 creator A5002111219 @default.
• W4378746798 creator A5015978228 @default.
• W4378746798 creator A5021293751 @default.
• W4378746798 creator A5023153467 @default.
• W4378746798 creator A5056058855 @default.
• W4378746798 creator A5075600845 @default.
• W4378746798 creator A5080512785 @default.
• W4378746798 creator A5080595018 @default.
• W4378746798 date "2023-05-11" @default.
• W4378746798 modified "2023-09-27" @default.
• W4378746798 title "RNA-sequencing approach for exploring the protective mechanisms of dexmedetomidine on pancreatic injury in severe acute pancreatitis" @default.
• W4378746798 cites W2020370872 @default.
• W4378746798 cites W2063513460 @default.
• W4378746798 cites W2106956867 @default.
• W4378746798 cites W2570117275 @default.
• W4378746798 cites W2780492013 @default.
• W4378746798 cites W2917899998 @default.
• W4378746798 cites W2987981020 @default.
• W4378746798 cites W3014305020 @default.
• W4378746798 cites W3046042799 @default.
• W4378746798 cites W3090254394 @default.
• W4378746798 cites W3107520611 @default.
• W4378746798 cites W3136937275 @default.
• W4378746798 cites W3165534117 @default.
• W4378746798 cites W3204483221 @default.
• W4378746798 cites W4200577692 @default.
• W4378746798 cites W4223903024 @default.
• W4378746798 cites W4280544660 @default.
• W4378746798 cites W4282838500 @default.
• W4378746798 cites W4284899705 @default.
• W4378746798 cites W4284976359 @default.
• W4378746798 cites W4290975642 @default.
• W4378746798 cites W4307548390 @default.
• W4378746798 cites W4309514401 @default.
• W4378746798 cites W4309728361 @default.
• W4378746798 cites W4310457155 @default.
• W4378746798 cites W4313555363 @default.
• W4378746798 cites W4313651705 @default.
• W4378746798 cites W4317568911 @default.
• W4378746798 cites W4318318747 @default.
• W4378746798 cites W4318753692 @default.
• W4378746798 cites W4318914844 @default.
• W4378746798 cites W4323294843 @default.
• W4378746798 doi "https://doi.org/10.3389/fphar.2023.1189486" @default.
• W4378746798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37251314" @default.
• W4378746798 hasPublicationYear "2023" @default.
• W4378746798 type Work @default.
• W4378746798 citedByCount "0" @default.
• W4378746798 crossrefType "journal-article" @default.
• W4378746798 hasAuthorship W4378746798A5002111219 @default.
• W4378746798 hasAuthorship W4378746798A5015978228 @default.
• W4378746798 hasAuthorship W4378746798A5021293751 @default.
• W4378746798 hasAuthorship W4378746798A5023153467 @default.
• W4378746798 hasAuthorship W4378746798A5056058855 @default.
• W4378746798 hasAuthorship W4378746798A5075600845 @default.
• W4378746798 hasAuthorship W4378746798A5080512785 @default.
• W4378746798 hasAuthorship W4378746798A5080595018 @default.
• W4378746798 hasBestOaLocation W43787467981 @default.
• W4378746798 hasConcept C125473707 @default.
• W4378746798 hasConcept C126322002 @default.
• W4378746798 hasConcept C142724271 @default.
• W4378746798 hasConcept C190283241 @default.
• W4378746798 hasConcept C196795494 @default.
• W4378746798 hasConcept C204232928 @default.
• W4378746798 hasConcept C2775967933 @default.
• W4378746798 hasConcept C2776670229 @default.
• W4378746798 hasConcept C2780471426 @default.
• W4378746798 hasConcept C2991930265 @default.
• W4378746798 hasConcept C31573885 @default.
• W4378746798 hasConcept C55493867 @default.
• W4378746798 hasConcept C71924100 @default.
• W4378746798 hasConcept C86803240 @default.
• W4378746798 hasConcept C94030615 @default.
• W4378746798 hasConcept C98274493 @default.
• W4378746798 hasConceptScore W4378746798C125473707 @default.
• W4378746798 hasConceptScore W4378746798C126322002 @default.
• W4378746798 hasConceptScore W4378746798C142724271 @default.
• W4378746798 hasConceptScore W4378746798C190283241 @default.
• W4378746798 hasConceptScore W4378746798C196795494 @default.
• W4378746798 hasConceptScore W4378746798C204232928 @default.
• W4378746798 hasConceptScore W4378746798C2775967933 @default.
• W4378746798 hasConceptScore W4378746798C2776670229 @default.
• W4378746798 hasConceptScore W4378746798C2780471426 @default.
• W4378746798 hasConceptScore W4378746798C2991930265 @default.
• W4378746798 hasConceptScore W4378746798C31573885 @default.
• W4378746798 hasConceptScore W4378746798C55493867 @default.
• W4378746798 hasConceptScore W4378746798C71924100 @default.
• W4378746798 hasConceptScore W4378746798C86803240 @default.
• W4378746798 hasConceptScore W4378746798C94030615 @default.
• W4378746798 hasConceptScore W4378746798C98274493 @default.
• W4378746798 hasFunder F4320321001 @default.
• W4378746798 hasLocation W43787467981 @default.
• W4378746798 hasLocation W43787467982 @default.
• W4378746798 hasOpenAccess W4378746798 @default.
• W4378746798 hasPrimaryLocation W43787467981 @default.
• W4378746798 hasRelatedWork W2016553156 @default.
• W4378746798 hasRelatedWork W2068359807 @default.
• W4378746798 hasRelatedWork W2078483342 @default.

• next