FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378767774> ?p ?o ?g. }

• W4378767774 endingPage "128" @default.
• W4378767774 startingPage "117" @default.
• W4378767774 abstract "Baicalein is a bioactive flavone originally isolated from the roots of Scutellaria baicalensis, Scutellariala teriflora and Oroxylum indicum. The in vitro and in vivo anti-inflammatory and antibacterial properties of baicalein and pharmacokinetics after its single intramuscular administration were studied in Wistar rats. The in vitro anti-inflammatory activity of baicalein (10, 50 and 100 µM) was tested for its ability to inhibit the COX-2 enzyme by measuring PGE2 levels and determination of nitric oxide (NO) production in lipopolysaccharide (LPS) treated RAW 264.7 macrophage cells, in which baicalein was found to have significant inhibition of NO and PGE2 production in RAW 264.7 macrophage cells as compared with the LPS control group. The in vivo anti-inflammatory activity of baicalein (200 mg/kg) was assessed using the carrageenan-induced rat paw oedema model, following intramuscular injection. A significant percentage of inhibition of oedema volume was observed when compared with the carrageenan control group. In vitro and in vivo antibacterial activities of baicalein were determined by the micro broth dilution technique and neutropenic rat thigh infection model, wherein baicalein did not show any antibacterial property. Concentrations of baicalein were determined in rat plasma by high performance liquid chromatography (HPLC) after a single intramuscular administration at a dose of 200 mg/kg body weight, in which the mean peak plasma drug concentration (Cmax) of 0.77 ± 0.02 μg/mL was achieved at 0.08 h. The mean elimination half-life (t½β), the apparent volume of distribution (Vd(area)), total body clearance (Cl(B)) and mean residence time (MRT) were observed as 0.63 ± 0.06 h, 601.03 ± 28.18 L/kg, 677.39 ± 35.36 L/h/kg and 0.76 ± 0.06 h, respectively. Conclusively, in the present study, baicalein did not show in vitro or in vivo antibacterial property, but proved to have good anti-inflammatory activity. The available anti-inflammatory drugs have proved to have side effects in veterinary and human therapeutics. In this situation, baicalein may become an effective alternative to non-steroidal anti-inflammatory drugs and should also be studied in target animal species. Further research should be carried out to improve the solubility and bioavailability of baicalein through injectable routes." @default.
• W4378767774 created "2023-05-31" @default.
• W4378767774 creator A5015094981 @default.
• W4378767774 creator A5049090181 @default.
• W4378767774 creator A5052976631 @default.
• W4378767774 creator A5056065096 @default.
• W4378767774 creator A5062059875 @default.
• W4378767774 date "2023-05-17" @default.
• W4378767774 modified "2023-09-27" @default.
• W4378767774 title "In vitro and in vivo anti-inflammatory, antibacterial and pharmacokinetic properties of baicalein" @default.
• W4378767774 doi "https://doi.org/10.24099/vet.arhiv.1502" @default.
• W4378767774 hasPublicationYear "2023" @default.
• W4378767774 type Work @default.
• W4378767774 citedByCount "0" @default.
• W4378767774 crossrefType "journal-article" @default.
• W4378767774 hasAuthorship W4378767774A5015094981 @default.
• W4378767774 hasAuthorship W4378767774A5049090181 @default.
• W4378767774 hasAuthorship W4378767774A5052976631 @default.
• W4378767774 hasAuthorship W4378767774A5056065096 @default.
• W4378767774 hasAuthorship W4378767774A5062059875 @default.
• W4378767774 hasBestOaLocation W43787677741 @default.
• W4378767774 hasConcept C112705442 @default.
• W4378767774 hasConcept C142724271 @default.
• W4378767774 hasConcept C150903083 @default.
• W4378767774 hasConcept C185592680 @default.
• W4378767774 hasConcept C188947578 @default.
• W4378767774 hasConcept C204787440 @default.
• W4378767774 hasConcept C207001950 @default.
• W4378767774 hasConcept C22979827 @default.
• W4378767774 hasConcept C2778153525 @default.
• W4378767774 hasConcept C2781466915 @default.
• W4378767774 hasConcept C71924100 @default.
• W4378767774 hasConcept C86803240 @default.
• W4378767774 hasConcept C98274493 @default.
• W4378767774 hasConceptScore W4378767774C112705442 @default.
• W4378767774 hasConceptScore W4378767774C142724271 @default.
• W4378767774 hasConceptScore W4378767774C150903083 @default.
• W4378767774 hasConceptScore W4378767774C185592680 @default.
• W4378767774 hasConceptScore W4378767774C188947578 @default.
• W4378767774 hasConceptScore W4378767774C204787440 @default.
• W4378767774 hasConceptScore W4378767774C207001950 @default.
• W4378767774 hasConceptScore W4378767774C22979827 @default.
• W4378767774 hasConceptScore W4378767774C2778153525 @default.
• W4378767774 hasConceptScore W4378767774C2781466915 @default.
• W4378767774 hasConceptScore W4378767774C71924100 @default.
• W4378767774 hasConceptScore W4378767774C86803240 @default.
• W4378767774 hasConceptScore W4378767774C98274493 @default.
• W4378767774 hasIssue "1" @default.
• W4378767774 hasLocation W43787677741 @default.
• W4378767774 hasOpenAccess W4378767774 @default.
• W4378767774 hasPrimaryLocation W43787677741 @default.
• W4378767774 hasRelatedWork W2028112905 @default.
• W4378767774 hasRelatedWork W2033056106 @default.
• W4378767774 hasRelatedWork W2057097799 @default.
• W4378767774 hasRelatedWork W2073247485 @default.
• W4378767774 hasRelatedWork W2237978516 @default.
• W4378767774 hasRelatedWork W2391770335 @default.
• W4378767774 hasRelatedWork W2527455654 @default.
• W4378767774 hasRelatedWork W2801767781 @default.
• W4378767774 hasRelatedWork W2898442316 @default.
• W4378767774 hasRelatedWork W3000071749 @default.
• W4378767774 hasVolume "93" @default.
• W4378767774 isParatext "false" @default.
• W4378767774 isRetracted "false" @default.
• W4378767774 workType "article" @default.