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• W4378780963 abstract "Abstract Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with endothelial dysfunction. We aimed to determine the effects of prior coronavirus disease 2019 (COVID-19) on the coronary microvasculature accounting for time from COVID-19, disease severity, SARS-CoV-2 variants, and in subgroups of patients with diabetes and those with no known coronary artery disease. Methods and results Cases consisted of patients with previous COVID-19 who had clinically indicated positron emission tomography (PET) imaging and were matched 1:3 on clinical and cardiovascular risk factors to controls having no prior infection. Myocardial flow reserve (MFR) was calculated as the ratio of stress to rest myocardial blood flow (MBF) in mL/min/g of the left ventricle. Comparisons between cases and controls were made for the odds and prevalence of impaired MFR (MFR &lt; 2). We included 271 cases matched to 815 controls (mean ± SD age 65 ± 12 years, 52% men). The median (inter-quartile range) number of days between COVID-19 infection and PET imaging was 174 (58–338) days. Patients with prior COVID-19 had a statistically significant higher odds of MFR &lt;2 (adjusted odds ratio 3.1, 95% confidence interval 2.8–4.25 P &lt; 0.001). Results were similar in clinically meaningful subgroups. The proportion of cases with MFR &lt;2 peaked 6–9 months from imaging with a statistically non-significant downtrend afterwards and was comparable across SARS-CoV-2 variants but increased with increasing severity of infection. Conclusion The prevalence of impaired MFR is similar by duration of time from infection up to 1 year and SARS-CoV-2 variants, but significantly differs by severity of infection." @default.
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• W4378780963 date "2023-05-31" @default.
• W4378780963 modified "2023-10-18" @default.
• W4378780963 title "Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis" @default.
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• W4378780963 doi "https://doi.org/10.1093/ehjci/jead118" @default.
• W4378780963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37254693" @default.
• W4378780963 hasPublicationYear "2023" @default.
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