Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378781222> ?p ?o ?g. }
- W4378781222 abstract "Summary Efficient regeneration of bone defects caused by disease or significant trauma is a major challenge in current medicine, which is particularly difficult yet significant under the emerging psychological stress in the modern society. Notably, the brain–bone axis has been proposed as a prominent new concept in recent years, among which autonomic nerves act as an essential and emerging skeletal pathophysiological factor related to psychological stress. Studies have established that sympathetic cues lead to impairment of bone homeostasis mainly through acting on mesenchymal stem cells (MSCs) and their derivatives with also affecting the hematopoietic stem cell (HSC)-lineage osteoclasts, and the autonomic neural regulation of stem cell lineages in bone is increasingly recognized to contribute to the bone degenerative disease, osteoporosis. This review summarizes the distribution characteristics of autonomic nerves in bone, introduces the regulatory effects and mechanisms of autonomic nerves on MSC and HSC lineages, and expounds the crucial role of autonomic neural regulation on bone physiology and pathology, which acts as a bridge between the brain and the bone. With the translational perspective, we further highlight the autonomic neural basis of psychological stress-induced bone loss and a series of pharmaceutical therapeutic strategies and implications toward bone regeneration. The summary of research progress in this field will add knowledge to the current landscape of inter-organ crosstalk and provide a medicinal basis for the achievement of clinical bone regeneration in the future." @default.
- W4378781222 created "2023-06-01" @default.
- W4378781222 creator A5012217069 @default.
- W4378781222 creator A5038260960 @default.
- W4378781222 creator A5041891687 @default.
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- W4378781222 creator A5064725136 @default.
- W4378781222 creator A5068170742 @default.
- W4378781222 creator A5082928106 @default.
- W4378781222 date "2023-05-30" @default.
- W4378781222 modified "2023-10-15" @default.
- W4378781222 title "Autonomic neural regulation in mediating the brain–bone axis: mechanisms and implications for regeneration under psychological stress" @default.
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