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• W4378781640 endingPage "e0011356" @default.
• W4378781640 startingPage "e0011356" @default.
• W4378781640 abstract "Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam-targeted at the highest burden urban areas.Ten settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). The effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted.From the health sector perspective, the Wolbachia intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of Wolbachia releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits.Overall, we found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains." @default.
• W4378781640 created "2023-06-01" @default.
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• W4378781640 date "2023-05-30" @default.
• W4378781640 modified "2023-10-14" @default.
• W4378781640 title "An economic evaluation of Wolbachia deployments for dengue control in Vietnam" @default.
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• W4378781640 doi "https://doi.org/10.1371/journal.pntd.0011356" @default.
• W4378781640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37253037" @default.
• W4378781640 hasPublicationYear "2023" @default.
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