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• W4378782425 abstract "It has been well established that randomized clinical trials have poor external validity, resulting in findings that may not apply to relevant-or target-populations. When the trial is sampled from the target population, generalizability methods have been proposed to address the applicability of trial findings to target populations. When the trial sample and target populations are distinct, transportability methods may be applied for this purpose. However, generalizability and transportability studies present challenges, particularly around the strength of their conclusions. We review and summarize state-of-the-art methods for translating trial findings to target populations. We additionally provide a novel step-by-step guide to address these challenges, illustrating principles through a published case study. When conducted with rigor, generalizability and transportability studies can play an integral role in regulatory decisions by providing key real-world evidence." @default.
• W4378782425 created "2023-06-01" @default.
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• W4378782425 date "2023-05-26" @default.
• W4378782425 modified "2023-09-30" @default.
• W4378782425 title "An Overview of Current Methods for Real-world Applications to Generalize or Transport Clinical Trial Findings to Target Populations of Interest" @default.
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• W4378782425 doi "https://doi.org/10.1097/ede.0000000000001633" @default.
• W4378782425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37255252" @default.
• W4378782425 hasPublicationYear "2023" @default.
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