FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378783218> ?p ?o ?g. }

• W4378783218 endingPage "954" @default.
• W4378783218 startingPage "949" @default.
• W4378783218 abstract "Type III polyketide synthase (PKS) found in bacteria is known as 1,3,6,8-tetrahydroxynaphthalene synthase (THNS). Microbial type III PKSs synthesize various compounds that possess crucial biological functions and significant pharmaceutical activities. Based on our sequence analysis, we have identified a putative type III polyketide synthase from Nocardia sp. CS682 was named as ThnA. The role of ThnA, in Nocardia sp. CS682 during the biosynthesis of 1,3,6,8 tetrahydroxynaphthalene (THN), which is the key intermediate of 1-(α-L-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene (IBR-3) was characterized. ThnA utilized five molecules of malonyl-CoA as a starter substrate to generate the polyketide 1,3,6,8-tetrahydroxynaphthalene, which could spontaneously be oxidized to the red flaviolin compound 2,5,7-trihydroxy-1,4-naphthoquinone. The amino acid sequence alignment of ThnA revealed similarities with a previously identified type III PKS and identified Cys138, Phe188, His270, and Asn303 as four highly conserved active site amino acid residues, as found in other known polyketide synthases. In this study, we report the heterologous expression of the type III polyketide synthase thnA in S. lividans TK24 and the identification of THN production in a mutant strain. We also compared the transcription level of thnA in S. lividans TK24 and S. lividans pIBR25-thnA and found that thnA was only transcribed in the mutant." @default.
• W4378783218 created "2023-06-01" @default.
• W4378783218 creator A5024757091 @default.
• W4378783218 creator A5049380627 @default.
• W4378783218 creator A5075419018 @default.
• W4378783218 creator A5084093510 @default.
• W4378783218 date "2023-05-05" @default.
• W4378783218 modified "2023-09-29" @default.
• W4378783218 title "Identification of 1,3,6,8- Tetrahydroxynaphthalene Synthase (ThnA) from <i>Nocardia</i> sp. CS682" @default.
• W4378783218 cites W1979412000 @default.
• W4378783218 cites W1982793579 @default.
• W4378783218 cites W1984233546 @default.
• W4378783218 cites W1987615701 @default.
• W4378783218 cites W1996445531 @default.
• W4378783218 cites W2000176823 @default.
• W4378783218 cites W2003706451 @default.
• W4378783218 cites W2026438413 @default.
• W4378783218 cites W2030919404 @default.
• W4378783218 cites W2040792095 @default.
• W4378783218 cites W2046300825 @default.
• W4378783218 cites W2052577954 @default.
• W4378783218 cites W2055968612 @default.
• W4378783218 cites W2063212143 @default.
• W4378783218 cites W2087615412 @default.
• W4378783218 cites W2088109095 @default.
• W4378783218 cites W2112149046 @default.
• W4378783218 cites W2117732632 @default.
• W4378783218 cites W2125726546 @default.
• W4378783218 cites W2141158541 @default.
• W4378783218 cites W2141474275 @default.
• W4378783218 cites W2155143235 @default.
• W4378783218 cites W2402686561 @default.
• W4378783218 cites W2793361678 @default.
• W4378783218 cites W2908678317 @default.
• W4378783218 cites W2991823228 @default.
• W4378783218 cites W3137882545 @default.
• W4378783218 cites W3206606939 @default.
• W4378783218 cites W4282976485 @default.
• W4378783218 cites W4293733758 @default.
• W4378783218 doi "https://doi.org/10.4014/jmb.2303.03008" @default.
• W4378783218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37254303" @default.
• W4378783218 hasPublicationYear "2023" @default.
• W4378783218 type Work @default.
• W4378783218 citedByCount "0" @default.
• W4378783218 crossrefType "journal-article" @default.
• W4378783218 hasAuthorship W4378783218A5024757091 @default.
• W4378783218 hasAuthorship W4378783218A5049380627 @default.
• W4378783218 hasAuthorship W4378783218A5075419018 @default.
• W4378783218 hasAuthorship W4378783218A5084093510 @default.
• W4378783218 hasConcept C104317684 @default.
• W4378783218 hasConcept C108305142 @default.
• W4378783218 hasConcept C112243037 @default.
• W4378783218 hasConcept C143065580 @default.
• W4378783218 hasConcept C167625842 @default.
• W4378783218 hasConcept C181199279 @default.
• W4378783218 hasConcept C185592680 @default.
• W4378783218 hasConcept C2776060363 @default.
• W4378783218 hasConcept C2777763344 @default.
• W4378783218 hasConcept C2778635478 @default.
• W4378783218 hasConcept C2779920670 @default.
• W4378783218 hasConcept C40767141 @default.
• W4378783218 hasConcept C45484198 @default.
• W4378783218 hasConcept C523546767 @default.
• W4378783218 hasConcept C54355233 @default.
• W4378783218 hasConcept C553450214 @default.
• W4378783218 hasConcept C55493867 @default.
• W4378783218 hasConcept C71240020 @default.
• W4378783218 hasConcept C86803240 @default.
• W4378783218 hasConceptScore W4378783218C104317684 @default.
• W4378783218 hasConceptScore W4378783218C108305142 @default.
• W4378783218 hasConceptScore W4378783218C112243037 @default.
• W4378783218 hasConceptScore W4378783218C143065580 @default.
• W4378783218 hasConceptScore W4378783218C167625842 @default.
• W4378783218 hasConceptScore W4378783218C181199279 @default.
• W4378783218 hasConceptScore W4378783218C185592680 @default.
• W4378783218 hasConceptScore W4378783218C2776060363 @default.
• W4378783218 hasConceptScore W4378783218C2777763344 @default.
• W4378783218 hasConceptScore W4378783218C2778635478 @default.
• W4378783218 hasConceptScore W4378783218C2779920670 @default.
• W4378783218 hasConceptScore W4378783218C40767141 @default.
• W4378783218 hasConceptScore W4378783218C45484198 @default.
• W4378783218 hasConceptScore W4378783218C523546767 @default.
• W4378783218 hasConceptScore W4378783218C54355233 @default.
• W4378783218 hasConceptScore W4378783218C553450214 @default.
• W4378783218 hasConceptScore W4378783218C55493867 @default.
• W4378783218 hasConceptScore W4378783218C71240020 @default.
• W4378783218 hasConceptScore W4378783218C86803240 @default.
• W4378783218 hasFunder F4320322120 @default.
• W4378783218 hasFunder F4320322349 @default.
• W4378783218 hasIssue "7" @default.
• W4378783218 hasLocation W43787832181 @default.
• W4378783218 hasLocation W43787832182 @default.
• W4378783218 hasOpenAccess W4378783218 @default.
• W4378783218 hasPrimaryLocation W43787832181 @default.
• W4378783218 hasRelatedWork W1986743634 @default.
• W4378783218 hasRelatedWork W2040686371 @default.
• W4378783218 hasRelatedWork W2048422892 @default.
• W4378783218 hasRelatedWork W2080279693 @default.

• next