Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378783417> ?p ?o ?g. }
- W4378783417 abstract "The immune function of normal T cells partially depends on the maneuvering of lipid metabolism through various stages and subsets. Interestingly, T-cell malignancies also reprogram their lipid metabolism to fulfill bioenergetic demand for rapid division. The rewiring of lipid metabolism in T-cell malignancies not only provides survival benefits but also contributes to their stemness, invasion, metastasis, and angiogenesis. Owing to distinctive lipid metabolic programming in T-cell cancer, quantitative, qualitative, and spatial enrichment of specific lipid molecules occur. The formation of lipid rafts rich in cholesterol confers physical strength and sustains survival signals. The accumulation of lipids through de novo synthesis and uptake of free lipids contribute to the bioenergetic reserve required for robust demand during migration and metastasis. Lipid storage in cells leads to the formation of specialized structures known as lipid droplets. The inimitable changes in fatty acid synthesis (FAS) and fatty acid oxidation (FAO) are in dynamic balance in T-cell malignancies. FAO fuels the molecular pumps causing chemoresistance, while FAS offers structural and signaling lipids for rapid division. Lipid metabolism in T-cell cancer provides molecules having immunosuppressive abilities. Moreover, the distinctive composition of membrane lipids has implications for immune evasion by malignant cells of T-cell origin. Lipid droplets and lipid rafts are contributors to maintaining hallmarks of cancer in malignancies of T cells. In preclinical settings, molecular targeting of lipid metabolism in T-cell cancer potentiates the antitumor immunity and chemotherapeutic response. Thus, the direct and adjunct benefit of lipid metabolic targeting is expected to improve the clinical management of T-cell malignancies." @default.
- W4378783417 created "2023-06-01" @default.
- W4378783417 creator A5006543889 @default.
- W4378783417 creator A5011510010 @default.
- W4378783417 creator A5027465913 @default.
- W4378783417 creator A5028174754 @default.
- W4378783417 creator A5029094379 @default.
- W4378783417 creator A5037129919 @default.
- W4378783417 creator A5063828656 @default.
- W4378783417 date "2023-05-15" @default.
- W4378783417 modified "2023-09-23" @default.
- W4378783417 title "Orchestral role of lipid metabolic reprogramming in T-cell malignancy" @default.
- W4378783417 cites W1557260592 @default.
- W4378783417 cites W1565735996 @default.
- W4378783417 cites W1714259390 @default.
- W4378783417 cites W1963782995 @default.
- W4378783417 cites W1964021758 @default.
- W4378783417 cites W1965671023 @default.
- W4378783417 cites W1966125710 @default.
- W4378783417 cites W1974381618 @default.
- W4378783417 cites W1975286848 @default.
- W4378783417 cites W1977198374 @default.
- W4378783417 cites W1979037563 @default.
- W4378783417 cites W1986234170 @default.
- W4378783417 cites W1986507179 @default.
- W4378783417 cites W1993686673 @default.
- W4378783417 cites W1994070358 @default.
- W4378783417 cites W1996785788 @default.
- W4378783417 cites W1998958410 @default.
- W4378783417 cites W1999195849 @default.
- W4378783417 cites W2009559557 @default.
- W4378783417 cites W2010189440 @default.
- W4378783417 cites W2013439116 @default.
- W4378783417 cites W2014219207 @default.
- W4378783417 cites W2014349355 @default.
- W4378783417 cites W2014411539 @default.
- W4378783417 cites W2014624348 @default.
- W4378783417 cites W2016660749 @default.
- W4378783417 cites W2018146992 @default.
- W4378783417 cites W2025714915 @default.
- W4378783417 cites W2029857486 @default.
- W4378783417 cites W2031421581 @default.
- W4378783417 cites W2042605361 @default.
- W4378783417 cites W2045203330 @default.
- W4378783417 cites W2045530417 @default.
- W4378783417 cites W2045720893 @default.
- W4378783417 cites W2054917860 @default.
- W4378783417 cites W2056040807 @default.
- W4378783417 cites W2057001750 @default.
- W4378783417 cites W2058887761 @default.
- W4378783417 cites W2060817268 @default.
- W4378783417 cites W2060878129 @default.
- W4378783417 cites W2062800226 @default.
- W4378783417 cites W2063888187 @default.
- W4378783417 cites W2065734437 @default.
- W4378783417 cites W2067065265 @default.
- W4378783417 cites W2069193571 @default.
- W4378783417 cites W2069285055 @default.
- W4378783417 cites W2070909262 @default.
- W4378783417 cites W2075931901 @default.
- W4378783417 cites W2077609848 @default.
- W4378783417 cites W2082904887 @default.
- W4378783417 cites W2083075461 @default.
- W4378783417 cites W2086439732 @default.
- W4378783417 cites W2088253442 @default.
- W4378783417 cites W2107211259 @default.
- W4378783417 cites W2114407775 @default.
- W4378783417 cites W2116043556 @default.
- W4378783417 cites W2116676186 @default.
- W4378783417 cites W2117692326 @default.
- W4378783417 cites W2124922239 @default.
- W4378783417 cites W2130714435 @default.
- W4378783417 cites W2131065469 @default.
- W4378783417 cites W2131115981 @default.
- W4378783417 cites W2131435922 @default.
- W4378783417 cites W2136765222 @default.
- W4378783417 cites W2144399344 @default.
- W4378783417 cites W2146044826 @default.
- W4378783417 cites W2152014155 @default.
- W4378783417 cites W2152358473 @default.
- W4378783417 cites W2156466482 @default.
- W4378783417 cites W2158402891 @default.
- W4378783417 cites W2159728029 @default.
- W4378783417 cites W2163578961 @default.
- W4378783417 cites W2166312294 @default.
- W4378783417 cites W2172093498 @default.
- W4378783417 cites W2205148034 @default.
- W4378783417 cites W2223535266 @default.
- W4378783417 cites W2256950852 @default.
- W4378783417 cites W2294162086 @default.
- W4378783417 cites W2298914518 @default.
- W4378783417 cites W2328017834 @default.
- W4378783417 cites W2339138530 @default.
- W4378783417 cites W2344747184 @default.
- W4378783417 cites W2399064224 @default.
- W4378783417 cites W2508083436 @default.
- W4378783417 cites W2548311344 @default.
- W4378783417 cites W2553355011 @default.
- W4378783417 cites W2554694070 @default.
- W4378783417 cites W2558399594 @default.