Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378783419> ?p ?o ?g. }
- W4378783419 abstract "The causality and mechanism of dietary effects on brain aging are still unclear due to the long time scales of aging. The nematode Caenorhabditis elegans has contributed to aging research because of its short lifespan and easy genetic manipulation. When fed the standard laboratory diet, Escherichia coli , C. elegans experiences an age-dependent decline in temperature–food associative learning, called thermotaxis. To address if diet affects this decline, we screened 35 lactic acid bacteria as alternative diet and found that animals maintained high thermotaxis ability when fed a clade of Lactobacilli enriched with heterofermentative bacteria. Among them, Lactobacill us reuteri maintained the thermotaxis of aged animals without affecting their lifespan and motility. The effect of Lb. reuteri depends on the DAF-16 transcription factor functioning in neurons. Furthermore, RNA sequencing analysis revealed that differentially expressed genes between aged animals fed different bacteria were enriched with DAF-16 targets. Our results demonstrate that diet can impact brain aging in a daf-16 -dependent manner without changing the lifespan." @default.
- W4378783419 created "2023-06-01" @default.
- W4378783419 creator A5018923654 @default.
- W4378783419 creator A5031619898 @default.
- W4378783419 creator A5040571977 @default.
- W4378783419 creator A5043709929 @default.
- W4378783419 creator A5047837962 @default.
- W4378783419 creator A5050822865 @default.
- W4378783419 creator A5063292557 @default.
- W4378783419 creator A5083504396 @default.
- W4378783419 creator A5092051950 @default.
- W4378783419 date "2023-05-30" @default.
- W4378783419 modified "2023-10-16" @default.
- W4378783419 title "Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans" @default.
- W4378783419 cites W1580991607 @default.
- W4378783419 cites W1631908837 @default.
- W4378783419 cites W1864026313 @default.
- W4378783419 cites W1944127002 @default.
- W4378783419 cites W1965813899 @default.
- W4378783419 cites W1969894890 @default.
- W4378783419 cites W1975037912 @default.
- W4378783419 cites W1975585710 @default.
- W4378783419 cites W1977787135 @default.
- W4378783419 cites W1984548148 @default.
- W4378783419 cites W1990898134 @default.
- W4378783419 cites W1990947933 @default.
- W4378783419 cites W1993519767 @default.
- W4378783419 cites W2001047941 @default.
- W4378783419 cites W2009906860 @default.
- W4378783419 cites W2018262244 @default.
- W4378783419 cites W2019816797 @default.
- W4378783419 cites W2023923544 @default.
- W4378783419 cites W2023931178 @default.
- W4378783419 cites W2036369728 @default.
- W4378783419 cites W2041608466 @default.
- W4378783419 cites W2042986568 @default.
- W4378783419 cites W2043738446 @default.
- W4378783419 cites W2046989794 @default.
- W4378783419 cites W2049636331 @default.
- W4378783419 cites W2058792851 @default.
- W4378783419 cites W2062629127 @default.
- W4378783419 cites W2063294396 @default.
- W4378783419 cites W2064144155 @default.
- W4378783419 cites W2068613424 @default.
- W4378783419 cites W2069752037 @default.
- W4378783419 cites W2069954455 @default.
- W4378783419 cites W2076792376 @default.
- W4378783419 cites W2078683173 @default.
- W4378783419 cites W2079458003 @default.
- W4378783419 cites W2080029391 @default.
- W4378783419 cites W2087984446 @default.
- W4378783419 cites W2090091413 @default.
- W4378783419 cites W2097344907 @default.
- W4378783419 cites W2103428092 @default.
- W4378783419 cites W2108024591 @default.
- W4378783419 cites W2113130542 @default.
- W4378783419 cites W2118590890 @default.
- W4378783419 cites W2126490785 @default.
- W4378783419 cites W2130410032 @default.
- W4378783419 cites W2130973560 @default.
- W4378783419 cites W2132081049 @default.
- W4378783419 cites W2133230099 @default.
- W4378783419 cites W2137395936 @default.
- W4378783419 cites W2141891795 @default.
- W4378783419 cites W2144297530 @default.
- W4378783419 cites W2148027524 @default.
- W4378783419 cites W2148581106 @default.
- W4378783419 cites W2149074973 @default.
- W4378783419 cites W2151924038 @default.
- W4378783419 cites W2152824815 @default.
- W4378783419 cites W2160938187 @default.
- W4378783419 cites W2167279371 @default.
- W4378783419 cites W2168104516 @default.
- W4378783419 cites W2172886986 @default.
- W4378783419 cites W2188777107 @default.
- W4378783419 cites W2193120972 @default.
- W4378783419 cites W2196709866 @default.
- W4378783419 cites W2210476349 @default.
- W4378783419 cites W2216967354 @default.
- W4378783419 cites W2317201147 @default.
- W4378783419 cites W2338277226 @default.
- W4378783419 cites W2342079751 @default.
- W4378783419 cites W2345358373 @default.
- W4378783419 cites W2346617299 @default.
- W4378783419 cites W2433871124 @default.
- W4378783419 cites W2528628699 @default.
- W4378783419 cites W2529181501 @default.
- W4378783419 cites W2559227394 @default.
- W4378783419 cites W2597578033 @default.
- W4378783419 cites W2615592869 @default.
- W4378783419 cites W2739552610 @default.
- W4378783419 cites W2739622235 @default.
- W4378783419 cites W2740150675 @default.
- W4378783419 cites W2747545374 @default.
- W4378783419 cites W2750948426 @default.
- W4378783419 cites W2771210843 @default.
- W4378783419 cites W2785830560 @default.
- W4378783419 cites W2790046208 @default.
- W4378783419 cites W2797508799 @default.
- W4378783419 cites W2801881225 @default.