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- W4378783462 abstract "Abstract Objective To determine the structure and co‐occurrence patterns of mucosal fungal community in oral lichen planus (OLP) patients. Subjects and Methods Mucosal swab samples from 20 OLP patients and 10 healthy controls (HCs) were collected and the mucosal mycobiomes were sequenced. The abundance, frequency, and diversity of fungi were analyzed, as well as the inter‐genera interactions. The associations between fungal genera and OLP severity were further identified. Results At the genus level, the relative abundance of unclassified_Trichocomaceae was significantly decreased in the reticular and erosive OLP groups compared to HCs. Meanwhile, significantly lower levels of Pseudozyma were observed in the reticular OLP group compared to HCs. The negative:positive cohesiveness ratio was significantly lower in the OLP group than HCs, indicating a relatively unstable fungal ecological system in the OLP group. In the OLP group, the abundance of unclassified_Nectriaceae was significantly correlated with the reticulation/erythema/ulceration (REU) score. Conclusions Compared to HCs, the decreased stability of fungal communities and the decreased abundances of two genera ( unclassified_Trichocomaceae and Pseudozyma ) on buccal mucosa were identified in OLP patients." @default.
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- W4378783462 date "2023-05-30" @default.
- W4378783462 modified "2023-10-14" @default.
- W4378783462 title "Preliminary analysis of the buccal mucosal fungal microbiome in oral lichen planus patients" @default.
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- W4378783462 doi "https://doi.org/10.1111/jop.13439" @default.
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