Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378802169> ?p ?o ?g. }
- W4378802169 abstract "Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ∼10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways ( e.g., BRCA2 ). Personalized medicine approaches tailored toward patients' mutations would improve patients' outcome. To identify novel vulnerabilities of BRCA2 -deficient pancreatic cancer, we generated isogenic Brca2 -deficient murine pancreatic cancer cell lines and performed high-throughput drug screens. High-throughput drug screening revealed that Brca2 -deficient cells are sensitive to Bromodomain and Extraterminal Motif (BET) inhibitors, suggesting that BET inhibition might be a potential therapeutic approach. We found that BRCA2 deficiency increased autophagic flux, which was further enhanced by BET inhibition in Brca2 -deficient pancreatic cancer cells, resulting in autophagy-dependent cell death. Our data suggests that BET inhibition can be a novel therapeutic strategy for BRCA2 -deficient pancreatic cancer." @default.
- W4378802169 created "2023-06-01" @default.
- W4378802169 creator A5001446294 @default.
- W4378802169 creator A5002032711 @default.
- W4378802169 creator A5002852323 @default.
- W4378802169 creator A5006150283 @default.
- W4378802169 creator A5014394750 @default.
- W4378802169 creator A5034348335 @default.
- W4378802169 creator A5050507605 @default.
- W4378802169 creator A5050923233 @default.
- W4378802169 creator A5051180471 @default.
- W4378802169 creator A5052699073 @default.
- W4378802169 creator A5053353854 @default.
- W4378802169 creator A5084495237 @default.
- W4378802169 creator A5092052477 @default.
- W4378802169 date "2023-05-31" @default.
- W4378802169 modified "2023-09-30" @default.
- W4378802169 title "A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer" @default.
- W4378802169 cites W1590261010 @default.
- W4378802169 cites W1635615463 @default.
- W4378802169 cites W1939365747 @default.
- W4378802169 cites W1987313243 @default.
- W4378802169 cites W1994823455 @default.
- W4378802169 cites W2001591494 @default.
- W4378802169 cites W2010916968 @default.
- W4378802169 cites W2015943054 @default.
- W4378802169 cites W2041535798 @default.
- W4378802169 cites W2049015983 @default.
- W4378802169 cites W2059493323 @default.
- W4378802169 cites W2095294326 @default.
- W4378802169 cites W2102967423 @default.
- W4378802169 cites W2125789330 @default.
- W4378802169 cites W2131220327 @default.
- W4378802169 cites W2134536765 @default.
- W4378802169 cites W2153958791 @default.
- W4378802169 cites W2232697670 @default.
- W4378802169 cites W2344726805 @default.
- W4378802169 cites W2403056614 @default.
- W4378802169 cites W2547933649 @default.
- W4378802169 cites W2597018254 @default.
- W4378802169 cites W2597062310 @default.
- W4378802169 cites W2748710555 @default.
- W4378802169 cites W2765688504 @default.
- W4378802169 cites W2776352834 @default.
- W4378802169 cites W2783887386 @default.
- W4378802169 cites W2791796258 @default.
- W4378802169 cites W2801652358 @default.
- W4378802169 cites W2913685527 @default.
- W4378802169 cites W2920097475 @default.
- W4378802169 cites W2920147611 @default.
- W4378802169 cites W2939427895 @default.
- W4378802169 cites W2945696330 @default.
- W4378802169 cites W2947826965 @default.
- W4378802169 cites W2953651531 @default.
- W4378802169 cites W2955684825 @default.
- W4378802169 cites W2967596375 @default.
- W4378802169 cites W3007090700 @default.
- W4378802169 cites W3125951967 @default.
- W4378802169 cites W3138474425 @default.
- W4378802169 cites W3198464166 @default.
- W4378802169 cites W3205314261 @default.
- W4378802169 cites W3217156549 @default.
- W4378802169 cites W4200139426 @default.
- W4378802169 cites W4206841660 @default.
- W4378802169 cites W4220871191 @default.
- W4378802169 cites W4281759502 @default.
- W4378802169 cites W4283754092 @default.
- W4378802169 doi "https://doi.org/10.1101/2023.05.30.542934" @default.
- W4378802169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37398312" @default.
- W4378802169 hasPublicationYear "2023" @default.
- W4378802169 type Work @default.
- W4378802169 citedByCount "0" @default.
- W4378802169 crossrefType "posted-content" @default.
- W4378802169 hasAuthorship W4378802169A5001446294 @default.
- W4378802169 hasAuthorship W4378802169A5002032711 @default.
- W4378802169 hasAuthorship W4378802169A5002852323 @default.
- W4378802169 hasAuthorship W4378802169A5006150283 @default.
- W4378802169 hasAuthorship W4378802169A5014394750 @default.
- W4378802169 hasAuthorship W4378802169A5034348335 @default.
- W4378802169 hasAuthorship W4378802169A5050507605 @default.
- W4378802169 hasAuthorship W4378802169A5050923233 @default.
- W4378802169 hasAuthorship W4378802169A5051180471 @default.
- W4378802169 hasAuthorship W4378802169A5052699073 @default.
- W4378802169 hasAuthorship W4378802169A5053353854 @default.
- W4378802169 hasAuthorship W4378802169A5084495237 @default.
- W4378802169 hasAuthorship W4378802169A5092052477 @default.
- W4378802169 hasBestOaLocation W43788021691 @default.
- W4378802169 hasConcept C104317684 @default.
- W4378802169 hasConcept C121608353 @default.
- W4378802169 hasConcept C126322002 @default.
- W4378802169 hasConcept C134935766 @default.
- W4378802169 hasConcept C190283241 @default.
- W4378802169 hasConcept C203522944 @default.
- W4378802169 hasConcept C2778502085 @default.
- W4378802169 hasConcept C2780210213 @default.
- W4378802169 hasConcept C2780862049 @default.
- W4378802169 hasConcept C41091548 @default.
- W4378802169 hasConcept C502942594 @default.
- W4378802169 hasConcept C54355233 @default.
- W4378802169 hasConcept C71924100 @default.