Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378802783> ?p ?o ?g. }
- W4378802783 endingPage "961" @default.
- W4378802783 startingPage "946" @default.
- W4378802783 abstract "Despite the remarkable success of autologous chimeric antigen receptor (CAR) T cells, some patients relapse due to tumor antigen escape and low or uneven antigen expression, among other mechanisms. Therapeutic options after relapse are limited, emphasizing the need to optimize current approaches. In addition, there is a need to develop allogeneic off-the-shelf therapies from healthy donors that are readily available at the time of treatment decision and can overcome limitations of current autologous approaches. To address both challenges simultaneously, we generated a CD20xCD22 dual allogeneic CAR T cell. Herein, we demonstrate that allogeneic CD20x22 CAR T cells display robust, sustained and dose-dependent activity in vitro and in vivo, while efficiently targeting primary B-cell non-Hodgkin lymphoma (B-NHL) samples with heterogeneous levels of CD22 and CD20. Altogether, we provide preclinical proof-of-concept data for an allogeneic dual CAR T cell to overcome current mechanisms of resistance to CAR T-cell therapies in B-NHL, while providing a potential alternative to CD19 targeting." @default.
- W4378802783 created "2023-06-01" @default.
- W4378802783 creator A5003136495 @default.
- W4378802783 creator A5006848089 @default.
- W4378802783 creator A5020371132 @default.
- W4378802783 creator A5025522814 @default.
- W4378802783 creator A5043736388 @default.
- W4378802783 creator A5049138861 @default.
- W4378802783 creator A5053302683 @default.
- W4378802783 creator A5063923381 @default.
- W4378802783 creator A5069501075 @default.
- W4378802783 creator A5074579607 @default.
- W4378802783 creator A5078915906 @default.
- W4378802783 creator A5091861950 @default.
- W4378802783 date "2023-05-31" @default.
- W4378802783 modified "2023-10-17" @default.
- W4378802783 title "Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies" @default.
- W4378802783 cites W1619537825 @default.
- W4378802783 cites W1839053269 @default.
- W4378802783 cites W2082189475 @default.
- W4378802783 cites W2141139539 @default.
- W4378802783 cites W2327135475 @default.
- W4378802783 cites W2514418134 @default.
- W4378802783 cites W2582851869 @default.
- W4378802783 cites W2583070206 @default.
- W4378802783 cites W2773804840 @default.
- W4378802783 cites W2783525457 @default.
- W4378802783 cites W2786758731 @default.
- W4378802783 cites W2787621143 @default.
- W4378802783 cites W2801641802 @default.
- W4378802783 cites W2806451935 @default.
- W4378802783 cites W2888063816 @default.
- W4378802783 cites W2893585523 @default.
- W4378802783 cites W2899700403 @default.
- W4378802783 cites W2911254867 @default.
- W4378802783 cites W2919051790 @default.
- W4378802783 cites W2937946645 @default.
- W4378802783 cites W2939047778 @default.
- W4378802783 cites W2942680040 @default.
- W4378802783 cites W2985430423 @default.
- W4378802783 cites W2990867581 @default.
- W4378802783 cites W2998345757 @default.
- W4378802783 cites W3003422194 @default.
- W4378802783 cites W3012942658 @default.
- W4378802783 cites W3016233874 @default.
- W4378802783 cites W3036279197 @default.
- W4378802783 cites W3037557840 @default.
- W4378802783 cites W3040437182 @default.
- W4378802783 cites W3095855647 @default.
- W4378802783 cites W3113171896 @default.
- W4378802783 cites W3120017373 @default.
- W4378802783 cites W3126684855 @default.
- W4378802783 cites W3128646645 @default.
- W4378802783 cites W3135011427 @default.
- W4378802783 cites W3137217625 @default.
- W4378802783 cites W3138763824 @default.
- W4378802783 cites W3168223213 @default.
- W4378802783 cites W3172108427 @default.
- W4378802783 cites W3183792933 @default.
- W4378802783 cites W3200091019 @default.
- W4378802783 cites W3211478332 @default.
- W4378802783 cites W3211947906 @default.
- W4378802783 cites W3212687340 @default.
- W4378802783 cites W3212699181 @default.
- W4378802783 cites W3213274791 @default.
- W4378802783 cites W3213904764 @default.
- W4378802783 cites W3216256147 @default.
- W4378802783 cites W4210589143 @default.
- W4378802783 cites W4220655611 @default.
- W4378802783 cites W4221030777 @default.
- W4378802783 cites W4221125141 @default.
- W4378802783 cites W4225004652 @default.
- W4378802783 cites W4281398912 @default.
- W4378802783 cites W4281629220 @default.
- W4378802783 cites W4283757099 @default.
- W4378802783 cites W4296685812 @default.
- W4378802783 cites W4304112200 @default.
- W4378802783 cites W4310112833 @default.
- W4378802783 doi "https://doi.org/10.1158/2326-6066.cir-22-0910" @default.
- W4378802783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37257169" @default.
- W4378802783 hasPublicationYear "2023" @default.
- W4378802783 type Work @default.
- W4378802783 citedByCount "0" @default.
- W4378802783 crossrefType "journal-article" @default.
- W4378802783 hasAuthorship W4378802783A5003136495 @default.
- W4378802783 hasAuthorship W4378802783A5006848089 @default.
- W4378802783 hasAuthorship W4378802783A5020371132 @default.
- W4378802783 hasAuthorship W4378802783A5025522814 @default.
- W4378802783 hasAuthorship W4378802783A5043736388 @default.
- W4378802783 hasAuthorship W4378802783A5049138861 @default.
- W4378802783 hasAuthorship W4378802783A5053302683 @default.
- W4378802783 hasAuthorship W4378802783A5063923381 @default.
- W4378802783 hasAuthorship W4378802783A5069501075 @default.
- W4378802783 hasAuthorship W4378802783A5074579607 @default.
- W4378802783 hasAuthorship W4378802783A5078915906 @default.
- W4378802783 hasAuthorship W4378802783A5091861950 @default.
- W4378802783 hasBestOaLocation W43788027831 @default.
- W4378802783 hasConcept C147483822 @default.